Fusobacterium nucleatum downregulated MLH1 expression in colorectal cancer by activating autophagy-lysosome pathway

Fusobacterium nucleatum downregulated MLH1 expression in colorectal cancer by activating autophagy-lysosome pathway

BackgroundsFusobacterium nucleatum (F. nucleatum) has been shown to be associated with immunotherapy in colorectal cancer (CRC), but its exact mechanism needs to be further explored.MethodsWe first analyzed the correlation between F. nucleatum abundance and mismatch repair (MMR) protein deficiency i...

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Bibliographic Details
Main Authors: Tingting Ding, Minkang Wu, Li Zhao, Hu Liu, Xuanke Cao, Jing Guo, Xingchen Zhu, Lamei Zhao, Heping Zhang, Yaohui Gao, Qing Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
colorectal cancer
Fusobacterium nucleatum
MLH1 deficiency
autophagy-lysosome pathway
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1586146/full
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