ANALYSIS OF STRUCTURAL FEATURES OF THE KETO-KETAL ISOMERS OF WARFARIN BY SPECTRAL METHODS
As a result of the studies was shown that the relative ratios of isomers by integration in DMSO-d6: (S, R)-warfarin – (S, S)-warfarin – open chain warfarin are 70%: 28%: 2%; in СDCl3 are 45%: 40%: 15%. In the IR spectra of warfarin specific absorption bands are observed in the regions 3271–3277 cm-1...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/556 |
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| Summary: | As a result of the studies was shown that the relative ratios of isomers by integration in DMSO-d6: (S, R)-warfarin – (S, S)-warfarin – open chain warfarin are 70%: 28%: 2%; in СDCl3 are 45%: 40%: 15%. In the IR spectra of warfarin specific absorption bands are observed in the regions 3271–3277 cm-1, 1681–1682 cm-1, 1103–1076 cm-1, corresponding to:νOH, νCH=CH: νas C–O–C. The molecular peak of warfarin after silylation has m/z 380 corresponding to the mass of trimethylsilyl-warfarin. Thus, the possibility of using IR, NMR spectroscopy and chromatography-mass spectrometry to confirm the authenticity of warfarin derivatives has been demonstrated. |
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| ISSN: | 2305-2066 2658-5049 |