Enhancing tofacitinib’s therapeutic efficacy in murine arthritis with a synbiotic formulation comprising Bacillus megaterium DSM 32963 and an Omega-3 fatty acid lysine salt

Enhancing tofacitinib’s therapeutic efficacy in murine arthritis with a synbiotic formulation comprising Bacillus megaterium DSM 32963 and an Omega-3 fatty acid lysine salt

IntroductionOmega-3 polyunsaturated fatty acids (n3-PUFA) are known for their anti-inflammatory benefits, particularly in chronic conditions like rheumatoid arthritis (RA). To resolve an acute inflammation, conversion of n3-PUFA into specialized pro-resolving mediators (SPM) is crucial. Recently, it...

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Bibliographic Details
Main Authors: Annette Zehrer, Alexandra Rausch, Paul M. Jordan, Oliver Werz, Heike Tom Dieck, Thomas Berngruber
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
probiotic
SPM
n3-PUFA
synbiotic
rheumatoid arthritis
nutritional supplement
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1540878/full
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