A meta-analysis of the value of indocyanine green fluorescence imaging in guiding surgical resection of primary and metastatic liver cancer
Objective: This meta-analysis aimed to evaluate the value of indocyanine green fluorescence imaging in precision resection surgery for primary and metastatic liver cancer. Methods: A systematic search of PubMed, Embase, Scopus, Cochrane Library, Web of Science, ScienceDirect, and major scientific we...
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| Format: | Article |
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Elsevier
2025-04-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025000195 |
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| author | Dali Xiong Jiaran Li Li Li Fuhao Xu Tao Hu He Zhu Xiaohui Xu Yawen Sun Shuanghu Yuan |
| author_facet | Dali Xiong Jiaran Li Li Li Fuhao Xu Tao Hu He Zhu Xiaohui Xu Yawen Sun Shuanghu Yuan |
| author_sort | Dali Xiong |
| collection | DOAJ |
| description | Objective: This meta-analysis aimed to evaluate the value of indocyanine green fluorescence imaging in precision resection surgery for primary and metastatic liver cancer. Methods: A systematic search of PubMed, Embase, Scopus, Cochrane Library, Web of Science, ScienceDirect, and major scientific websites was conducted until June 2024. Randomized controlled trials and observational studies comparing indocyanine green fluorescence imaging-guided liver cancer resection with traditional methods were included. The meta-analysis incorporated overall outcomes and subgroup outcomes based on liver cancer types (primary and metastatic). StataSE 12.0 software was used for statistical analysis after a quality assessment of the included studies. Results: Twenty studies involving 1,283 patients with liver cancer were included. The results showed that indocyanine green fluorescence imaging significantly reduced intraoperative blood loss [Weighted mean difference (WMD), –88.75; 95 % CI, –128.48 to –49.02, p < 0.05], transfusion rate [Odds ratios (OR), 0.5; 95 % CI, 0.36–0.7, p < 0.05], hospital stay duration [WMD, –1.11; 95 % CI, –1.79 to –0.43, p < 0.05], and the overall complication rate [OR, 0.59; 95 % CI, 0.44–0.79, p < 0.05]. However, no significant differences were observed in operative time or in the subgroup analysis for metastatic liver cancer. Conclusion: Indocyanine green fluorescence imaging is a safe and effective intraoperative navigation technique that improves surgical outcomes and prognostic indicators in liver cancer resection. However, its efficacy in metastatic liver cancer surgery requires further validation through larger-scale, rigorous, prospective, randomized controlled trials. |
| format | Article |
| id | doaj-art-d1b33151756a456e8c3159d004492ded |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-d1b33151756a456e8c3159d004492ded2025-02-05T04:31:20ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-04-0152104489A meta-analysis of the value of indocyanine green fluorescence imaging in guiding surgical resection of primary and metastatic liver cancerDali Xiong0Jiaran Li1Li Li2Fuhao Xu3Tao Hu4He Zhu5Xiaohui Xu6Yawen Sun7Shuanghu Yuan8Department of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou, China; Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaDepartment of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, ChinaDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaQingdao Municipal Hospital, Qingdao, Shandong, ChinaQingdao Municipal Hospital, Qingdao, Shandong, ChinaDepartment of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou, China; Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China; Department of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China; Corresponding author at: Department of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.Objective: This meta-analysis aimed to evaluate the value of indocyanine green fluorescence imaging in precision resection surgery for primary and metastatic liver cancer. Methods: A systematic search of PubMed, Embase, Scopus, Cochrane Library, Web of Science, ScienceDirect, and major scientific websites was conducted until June 2024. Randomized controlled trials and observational studies comparing indocyanine green fluorescence imaging-guided liver cancer resection with traditional methods were included. The meta-analysis incorporated overall outcomes and subgroup outcomes based on liver cancer types (primary and metastatic). StataSE 12.0 software was used for statistical analysis after a quality assessment of the included studies. Results: Twenty studies involving 1,283 patients with liver cancer were included. The results showed that indocyanine green fluorescence imaging significantly reduced intraoperative blood loss [Weighted mean difference (WMD), –88.75; 95 % CI, –128.48 to –49.02, p < 0.05], transfusion rate [Odds ratios (OR), 0.5; 95 % CI, 0.36–0.7, p < 0.05], hospital stay duration [WMD, –1.11; 95 % CI, –1.79 to –0.43, p < 0.05], and the overall complication rate [OR, 0.59; 95 % CI, 0.44–0.79, p < 0.05]. However, no significant differences were observed in operative time or in the subgroup analysis for metastatic liver cancer. Conclusion: Indocyanine green fluorescence imaging is a safe and effective intraoperative navigation technique that improves surgical outcomes and prognostic indicators in liver cancer resection. However, its efficacy in metastatic liver cancer surgery requires further validation through larger-scale, rigorous, prospective, randomized controlled trials.http://www.sciencedirect.com/science/article/pii/S1572100025000195Fluorescence imagingPrimary liver cancerMetastatic liver cancerSurgical navigationMeta-analysis |
| spellingShingle | Dali Xiong Jiaran Li Li Li Fuhao Xu Tao Hu He Zhu Xiaohui Xu Yawen Sun Shuanghu Yuan A meta-analysis of the value of indocyanine green fluorescence imaging in guiding surgical resection of primary and metastatic liver cancer Photodiagnosis and Photodynamic Therapy Fluorescence imaging Primary liver cancer Metastatic liver cancer Surgical navigation Meta-analysis |
| title | A meta-analysis of the value of indocyanine green fluorescence imaging in guiding surgical resection of primary and metastatic liver cancer |
| title_full | A meta-analysis of the value of indocyanine green fluorescence imaging in guiding surgical resection of primary and metastatic liver cancer |
| title_fullStr | A meta-analysis of the value of indocyanine green fluorescence imaging in guiding surgical resection of primary and metastatic liver cancer |
| title_full_unstemmed | A meta-analysis of the value of indocyanine green fluorescence imaging in guiding surgical resection of primary and metastatic liver cancer |
| title_short | A meta-analysis of the value of indocyanine green fluorescence imaging in guiding surgical resection of primary and metastatic liver cancer |
| title_sort | meta analysis of the value of indocyanine green fluorescence imaging in guiding surgical resection of primary and metastatic liver cancer |
| topic | Fluorescence imaging Primary liver cancer Metastatic liver cancer Surgical navigation Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025000195 |
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