Effect of magnetization on antibacterial, lipid-lowering and antioxidant activities of isoquinoline alkaloids
Abstract The magnetization strategy of isoquinoline alkaloids has been successfully used in the extraction and isolation, but the effect of the magnetization on biological activities of those alkaloids still deserves further investigation. Therefore, the antibacterial, lipid-lowering and antioxidant...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-88200-3 |
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| author | Xueting Feng Weijie Li Xiaoling Wang Jie Tang Shun Yao |
| author_facet | Xueting Feng Weijie Li Xiaoling Wang Jie Tang Shun Yao |
| author_sort | Xueting Feng |
| collection | DOAJ |
| description | Abstract The magnetization strategy of isoquinoline alkaloids has been successfully used in the extraction and isolation, but the effect of the magnetization on biological activities of those alkaloids still deserves further investigation. Therefore, the antibacterial, lipid-lowering and antioxidant activities of five isoquinoline alkaloids (berberine, tetrahydroberberine, palmatine, tetrahydropalmatine and tetrahydropapavine) before and after magnetization were compared in this study, and the results showed that the relevant activities were enhanced after magnetization. Additionally, among the five magnetic derivatives studied, berberine magnetic derivative ([Ber·H]+[FeCl4]−) had the best antibacterial effect on S. aureus and E. coli with MIC of 200 and 800 µM, respectively; palmatine magnetic derivative ([Pal·H]+[FeCl4]−) showed the strongest lipid-lowering activity with IC50 of 429 mM, and the inhibitory effect and type on lipase was reversible and mixed inhibition of competition and non-competition type; tetrahydroberberine magnetic derivative ([THBer·H]+[FeCl4]−) had the strongest antioxidant activity. This study provides new ideas and references for the further application of magnetization strategy. |
| format | Article |
| id | doaj-art-d1a8f2560a984aa594ee237569799a2b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-d1a8f2560a984aa594ee237569799a2b2025-02-02T12:23:19ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-025-88200-3Effect of magnetization on antibacterial, lipid-lowering and antioxidant activities of isoquinoline alkaloidsXueting Feng0Weijie Li1Xiaoling Wang2Jie Tang3Shun Yao4College of Pharmacy and Food, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, Southwest Minzu UniversityCollege of Chemistry and Life Science, Sichuan University Key Laboratory of Optimization and Application of Functional Molecular Structure, Chengdu Normal UniversityCollege of Pharmacy and Food, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, Southwest Minzu UniversityCollege of Chemical Engineering, Sichuan University of Science & EngineeringSchool of Chemical Engineering, Sichuan UniversityAbstract The magnetization strategy of isoquinoline alkaloids has been successfully used in the extraction and isolation, but the effect of the magnetization on biological activities of those alkaloids still deserves further investigation. Therefore, the antibacterial, lipid-lowering and antioxidant activities of five isoquinoline alkaloids (berberine, tetrahydroberberine, palmatine, tetrahydropalmatine and tetrahydropapavine) before and after magnetization were compared in this study, and the results showed that the relevant activities were enhanced after magnetization. Additionally, among the five magnetic derivatives studied, berberine magnetic derivative ([Ber·H]+[FeCl4]−) had the best antibacterial effect on S. aureus and E. coli with MIC of 200 and 800 µM, respectively; palmatine magnetic derivative ([Pal·H]+[FeCl4]−) showed the strongest lipid-lowering activity with IC50 of 429 mM, and the inhibitory effect and type on lipase was reversible and mixed inhibition of competition and non-competition type; tetrahydroberberine magnetic derivative ([THBer·H]+[FeCl4]−) had the strongest antioxidant activity. This study provides new ideas and references for the further application of magnetization strategy.https://doi.org/10.1038/s41598-025-88200-3MagnetizationIsoquinoline alkaloidsAntibacterial activityLipid-lowering activityAntioxidant activity |
| spellingShingle | Xueting Feng Weijie Li Xiaoling Wang Jie Tang Shun Yao Effect of magnetization on antibacterial, lipid-lowering and antioxidant activities of isoquinoline alkaloids Scientific Reports Magnetization Isoquinoline alkaloids Antibacterial activity Lipid-lowering activity Antioxidant activity |
| title | Effect of magnetization on antibacterial, lipid-lowering and antioxidant activities of isoquinoline alkaloids |
| title_full | Effect of magnetization on antibacterial, lipid-lowering and antioxidant activities of isoquinoline alkaloids |
| title_fullStr | Effect of magnetization on antibacterial, lipid-lowering and antioxidant activities of isoquinoline alkaloids |
| title_full_unstemmed | Effect of magnetization on antibacterial, lipid-lowering and antioxidant activities of isoquinoline alkaloids |
| title_short | Effect of magnetization on antibacterial, lipid-lowering and antioxidant activities of isoquinoline alkaloids |
| title_sort | effect of magnetization on antibacterial lipid lowering and antioxidant activities of isoquinoline alkaloids |
| topic | Magnetization Isoquinoline alkaloids Antibacterial activity Lipid-lowering activity Antioxidant activity |
| url | https://doi.org/10.1038/s41598-025-88200-3 |
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