Occult ovarian high-grade serous carcinoma presenting as isolated inguinal lymph node metastasis: A case report and literature review
Superficial inguinal lymph node (SILN) metastasis is rare in ovarian cancer, particularly as an isolated presentation without peritoneal dissemination. Here we report a case of solitary SILN metastasis in a patient with high-grade serous carcinoma of ovarian cancer and review previously reported cas...
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Elsevier
2025-05-01
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| Series: | Translational Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523325001020 |
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| author | XiaoJing Guan Zhi Ma JianHua Yang |
| author_facet | XiaoJing Guan Zhi Ma JianHua Yang |
| author_sort | XiaoJing Guan |
| collection | DOAJ |
| description | Superficial inguinal lymph node (SILN) metastasis is rare in ovarian cancer, particularly as an isolated presentation without peritoneal dissemination. Here we report a case of solitary SILN metastasis in a patient with high-grade serous carcinoma of ovarian cancer and review previously reported cases from literature. A 58-year-old woman presented with isolated right groin swelling (approximately 4 cm), excisional biopsy suggested ovarian origin but comprehensive imaging and laparoscopy failed to identify a primary intra-abdominal tumor, and postoperative pathology confirmed no evidence of ovarian involvement. Following multidisciplinary consultation, the patient received six cycles of paclitaxel (175 mg/m²) plus carboplatin (AUC-5) chemotherapy (21-day intervals). Remarkably, five years post-treatment, she remains disease-free, highlighting the potential for favorable outcomes even in rare metastatic presentations. This case demonstrates that ovarian cancer is not a disease confined to the intra-peritoneal cavity; SILN metastasis might occur in rare cases possibly via lymphatic and/or hematogenous spread route under specific circumstances. Further investigations related to risk factors and metastatic patterns are warranted to explore the mechanisms and clinical implications of isolated SILN metastasis in ovarian cancer. |
| format | Article |
| id | doaj-art-d1a602f560314cad88cf56ff7f4205df |
| institution | DOAJ |
| issn | 1936-5233 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj-art-d1a602f560314cad88cf56ff7f4205df2025-08-20T03:03:27ZengElsevierTranslational Oncology1936-52332025-05-015510237110.1016/j.tranon.2025.102371Occult ovarian high-grade serous carcinoma presenting as isolated inguinal lymph node metastasis: A case report and literature reviewXiaoJing Guan0Zhi Ma1JianHua Yang2Department of Gynecology and Obstetrics, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, ChinaDepartment of Gynecology and Obstetrics, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, ChinaCorresponding author.; Department of Gynecology and Obstetrics, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, ChinaSuperficial inguinal lymph node (SILN) metastasis is rare in ovarian cancer, particularly as an isolated presentation without peritoneal dissemination. Here we report a case of solitary SILN metastasis in a patient with high-grade serous carcinoma of ovarian cancer and review previously reported cases from literature. A 58-year-old woman presented with isolated right groin swelling (approximately 4 cm), excisional biopsy suggested ovarian origin but comprehensive imaging and laparoscopy failed to identify a primary intra-abdominal tumor, and postoperative pathology confirmed no evidence of ovarian involvement. Following multidisciplinary consultation, the patient received six cycles of paclitaxel (175 mg/m²) plus carboplatin (AUC-5) chemotherapy (21-day intervals). Remarkably, five years post-treatment, she remains disease-free, highlighting the potential for favorable outcomes even in rare metastatic presentations. This case demonstrates that ovarian cancer is not a disease confined to the intra-peritoneal cavity; SILN metastasis might occur in rare cases possibly via lymphatic and/or hematogenous spread route under specific circumstances. Further investigations related to risk factors and metastatic patterns are warranted to explore the mechanisms and clinical implications of isolated SILN metastasis in ovarian cancer.http://www.sciencedirect.com/science/article/pii/S1936523325001020Ovarian cancerSuperficial inguinal lymph nodeLymphatic metastasisMechanism |
| spellingShingle | XiaoJing Guan Zhi Ma JianHua Yang Occult ovarian high-grade serous carcinoma presenting as isolated inguinal lymph node metastasis: A case report and literature review Translational Oncology Ovarian cancer Superficial inguinal lymph node Lymphatic metastasis Mechanism |
| title | Occult ovarian high-grade serous carcinoma presenting as isolated inguinal lymph node metastasis: A case report and literature review |
| title_full | Occult ovarian high-grade serous carcinoma presenting as isolated inguinal lymph node metastasis: A case report and literature review |
| title_fullStr | Occult ovarian high-grade serous carcinoma presenting as isolated inguinal lymph node metastasis: A case report and literature review |
| title_full_unstemmed | Occult ovarian high-grade serous carcinoma presenting as isolated inguinal lymph node metastasis: A case report and literature review |
| title_short | Occult ovarian high-grade serous carcinoma presenting as isolated inguinal lymph node metastasis: A case report and literature review |
| title_sort | occult ovarian high grade serous carcinoma presenting as isolated inguinal lymph node metastasis a case report and literature review |
| topic | Ovarian cancer Superficial inguinal lymph node Lymphatic metastasis Mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S1936523325001020 |
| work_keys_str_mv | AT xiaojingguan occultovarianhighgradeserouscarcinomapresentingasisolatedinguinallymphnodemetastasisacasereportandliteraturereview AT zhima occultovarianhighgradeserouscarcinomapresentingasisolatedinguinallymphnodemetastasisacasereportandliteraturereview AT jianhuayang occultovarianhighgradeserouscarcinomapresentingasisolatedinguinallymphnodemetastasisacasereportandliteraturereview |