Basigin links altered skeletal stem cell lineage dynamics with glucocorticoid-induced bone loss and impaired angiogenesis

Basigin links altered skeletal stem cell lineage dynamics with glucocorticoid-induced bone loss and impaired angiogenesis

Abstract Glucocorticoid (GC) induced osteoporosis (GIOP) and osteonecrosis remain a significant health issue with few approved therapies. Here, we investigate the cellular and molecular processes by which GCs affect osteogenesis and angiogenesis. We find that GC treatment reduces bone mass through d...

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Main Authors: Thomas H. Ambrosi, David Morales, Kun Chen, Ethan J. Hunt, Kelly C. Weldon, Amber N. Maifeld, Fatima I. M. Chavez, Yuting Wang, Liming Zhao, Luke Wang, Matthew P. Murphy, Amin Cressman, Erika E. Wheeler, Augustine M. Saiz, J. Kent Leach, Fernando A. Fierro, Charles K. F. Chan, Nancy E. Lane
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62881-w
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