Graphene oxide‐ellagic acid nanocomposite as effective anticancer and antimicrobial agent
Abstract In this study, ellagic acid (ELA), a skin anticancer drug, is capped on the surface(s) of functionalised graphene oxide (GO) nano‐sheets through electrostatic and π–π staking interactions. The prepared ELA‐GO nanocomposite have been thoroughly characterised by using eight techniques: Fourie...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-02-01
|
| Series: | IET Nanobiotechnology |
| Online Access: | https://doi.org/10.1049/nbt2.12009 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849683050264264704 |
|---|---|
| author | Samer Hasan Hussein‐Al‐Ali Suha Mujahed Abudoleh Mohd Zobir Hussein Saifullah Bullo Arul Palanisamy |
| author_facet | Samer Hasan Hussein‐Al‐Ali Suha Mujahed Abudoleh Mohd Zobir Hussein Saifullah Bullo Arul Palanisamy |
| author_sort | Samer Hasan Hussein‐Al‐Ali |
| collection | DOAJ |
| description | Abstract In this study, ellagic acid (ELA), a skin anticancer drug, is capped on the surface(s) of functionalised graphene oxide (GO) nano‐sheets through electrostatic and π–π staking interactions. The prepared ELA‐GO nanocomposite have been thoroughly characterised by using eight techniques: Fourier‐transform infrared spectroscopy (FTIR), zeta potential, X‐ray diffraction (XRD), thermogravimetric analysis (TGA), Raman spectroscopy, atomic force microscopy (AFM) topographic imaging, transmission electron microscopy (TEM), and surface morphology via scanning electron microscopy (SEM). Furthermore, ELA drug loading and release behaviours from ELA‐GO nanocomposite were studied. The ELA‐GO nanocomposite has a uniform size distribution averaging 88 nm and high drug loading capacity of 30 wt.%. The in vitro drug release behaviour of ELA from the nanocomposite was investigated by UV–Vis spectrometry at a wavelength of λmax 257 nm. The data confirmed prolonged ELA release over 5000 min at physiological pH (7.4). Finally, the IC50 of this ELA‐GO nanocomposite was found to be 6.16 µg/ml against B16 cell line; ELA and GO did not show any cytotoxic effects up to 50 µg/ml on the same cell lines. |
| format | Article |
| id | doaj-art-d19f9de49dd747dca12e16327f822e9d |
| institution | DOAJ |
| issn | 1751-8741 1751-875X |
| language | English |
| publishDate | 2021-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | IET Nanobiotechnology |
| spelling | doaj-art-d19f9de49dd747dca12e16327f822e9d2025-08-20T03:24:00ZengWileyIET Nanobiotechnology1751-87411751-875X2021-02-01151798910.1049/nbt2.12009Graphene oxide‐ellagic acid nanocomposite as effective anticancer and antimicrobial agentSamer Hasan Hussein‐Al‐Ali0Suha Mujahed Abudoleh1Mohd Zobir Hussein2Saifullah Bullo3Arul Palanisamy4Department of Chemistry Faculty of Science Isra University Amman JordanFaculty of Pharmacy Isra University Amman JordanMaterials Synthesis and Characterization Laboratory Institute of Advanced Technology (ITMA) University Putra Malaysia Selangor MalaysiaMaterials Synthesis and Characterization Laboratory Institute of Advanced Technology (ITMA) University Putra Malaysia Selangor MalaysiaLaboratory of Vaccines and Immunotherapeutics Institute of Bioscience University Putra Malaysia Selangor MalaysiaAbstract In this study, ellagic acid (ELA), a skin anticancer drug, is capped on the surface(s) of functionalised graphene oxide (GO) nano‐sheets through electrostatic and π–π staking interactions. The prepared ELA‐GO nanocomposite have been thoroughly characterised by using eight techniques: Fourier‐transform infrared spectroscopy (FTIR), zeta potential, X‐ray diffraction (XRD), thermogravimetric analysis (TGA), Raman spectroscopy, atomic force microscopy (AFM) topographic imaging, transmission electron microscopy (TEM), and surface morphology via scanning electron microscopy (SEM). Furthermore, ELA drug loading and release behaviours from ELA‐GO nanocomposite were studied. The ELA‐GO nanocomposite has a uniform size distribution averaging 88 nm and high drug loading capacity of 30 wt.%. The in vitro drug release behaviour of ELA from the nanocomposite was investigated by UV–Vis spectrometry at a wavelength of λmax 257 nm. The data confirmed prolonged ELA release over 5000 min at physiological pH (7.4). Finally, the IC50 of this ELA‐GO nanocomposite was found to be 6.16 µg/ml against B16 cell line; ELA and GO did not show any cytotoxic effects up to 50 µg/ml on the same cell lines.https://doi.org/10.1049/nbt2.12009 |
| spellingShingle | Samer Hasan Hussein‐Al‐Ali Suha Mujahed Abudoleh Mohd Zobir Hussein Saifullah Bullo Arul Palanisamy Graphene oxide‐ellagic acid nanocomposite as effective anticancer and antimicrobial agent IET Nanobiotechnology |
| title | Graphene oxide‐ellagic acid nanocomposite as effective anticancer and antimicrobial agent |
| title_full | Graphene oxide‐ellagic acid nanocomposite as effective anticancer and antimicrobial agent |
| title_fullStr | Graphene oxide‐ellagic acid nanocomposite as effective anticancer and antimicrobial agent |
| title_full_unstemmed | Graphene oxide‐ellagic acid nanocomposite as effective anticancer and antimicrobial agent |
| title_short | Graphene oxide‐ellagic acid nanocomposite as effective anticancer and antimicrobial agent |
| title_sort | graphene oxide ellagic acid nanocomposite as effective anticancer and antimicrobial agent |
| url | https://doi.org/10.1049/nbt2.12009 |
| work_keys_str_mv | AT samerhasanhusseinalali grapheneoxideellagicacidnanocompositeaseffectiveanticancerandantimicrobialagent AT suhamujahedabudoleh grapheneoxideellagicacidnanocompositeaseffectiveanticancerandantimicrobialagent AT mohdzobirhussein grapheneoxideellagicacidnanocompositeaseffectiveanticancerandantimicrobialagent AT saifullahbullo grapheneoxideellagicacidnanocompositeaseffectiveanticancerandantimicrobialagent AT arulpalanisamy grapheneoxideellagicacidnanocompositeaseffectiveanticancerandantimicrobialagent |