Imatinib-resistance without BCR/ABL Point Mutation in Chronic Myeloid Leukemia

Chronic myeloid leukemia (CML) is a myeloproliferative bone marrow neoplasm that occurs because of a fusion gene called BCR-ABL1. Imatinib -the inhibitor of this fusion geneis the target therapy in CML. But unfortunately, resistance against imatinib occurs in some patients. In September 2019 47-year...

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Main Author: Aytan Shirinova
Format: Article
Language:English
Published: Galenos Publishing House 2024-03-01
Series:Caucasian Medical Journal
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Online Access:https://caucasianmedj.com/articles/imatinib-resistance-without-bcrabl-point-mutation-in-chronic-myeloid-leukemia/doi/cmj.galenos.2024.36855
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author Aytan Shirinova
author_facet Aytan Shirinova
author_sort Aytan Shirinova
collection DOAJ
description Chronic myeloid leukemia (CML) is a myeloproliferative bone marrow neoplasm that occurs because of a fusion gene called BCR-ABL1. Imatinib -the inhibitor of this fusion geneis the target therapy in CML. But unfortunately, resistance against imatinib occurs in some patients. In September 2019 47-year-old male was diagnosed with CML-chronic phase and intermediate risk group. Imatinib has been prescribed as a first-line treatment. The patient did not achieve a major molecular response (MMR). Next-generation sequencing using a 54 myeloid-targeted gene panel was negative for ABL1 L248V, G250E, Y253H, E255K, F311L, T315I, F317L, F311I, M351T, and other point mutations. After Nilotinib patient achieved MMR within two years. Imatinib resistance is impediment during treating CML. In the future, new molecules for BCR-ABL inhibitors, combination therapy, and molecules entering the blood-brain barrier may improve the outcomes of therapy and prevent imatinib resistance in CML.
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spelling doaj-art-d19cd61d5c704ceb82f2a3b96da3241e2025-01-20T07:10:01ZengGalenos Publishing HouseCaucasian Medical Journal2980-18182024-03-01211210.4274/cmj.galenos.2024.36855Imatinib-resistance without BCR/ABL Point Mutation in Chronic Myeloid LeukemiaAytan Shirinova0https://orcid.org/0000-0002-2525-3069National Hematology and Blood Transfusion Center, Department of Hematology, Baku, AzerbaijanChronic myeloid leukemia (CML) is a myeloproliferative bone marrow neoplasm that occurs because of a fusion gene called BCR-ABL1. Imatinib -the inhibitor of this fusion geneis the target therapy in CML. But unfortunately, resistance against imatinib occurs in some patients. In September 2019 47-year-old male was diagnosed with CML-chronic phase and intermediate risk group. Imatinib has been prescribed as a first-line treatment. The patient did not achieve a major molecular response (MMR). Next-generation sequencing using a 54 myeloid-targeted gene panel was negative for ABL1 L248V, G250E, Y253H, E255K, F311L, T315I, F317L, F311I, M351T, and other point mutations. After Nilotinib patient achieved MMR within two years. Imatinib resistance is impediment during treating CML. In the future, new molecules for BCR-ABL inhibitors, combination therapy, and molecules entering the blood-brain barrier may improve the outcomes of therapy and prevent imatinib resistance in CML.https://caucasianmedj.com/articles/imatinib-resistance-without-bcrabl-point-mutation-in-chronic-myeloid-leukemia/doi/cmj.galenos.2024.36855imatinib-resistancecmlabl1 domain mutations
spellingShingle Aytan Shirinova
Imatinib-resistance without BCR/ABL Point Mutation in Chronic Myeloid Leukemia
Caucasian Medical Journal
imatinib-resistance
cml
abl1 domain mutations
title Imatinib-resistance without BCR/ABL Point Mutation in Chronic Myeloid Leukemia
title_full Imatinib-resistance without BCR/ABL Point Mutation in Chronic Myeloid Leukemia
title_fullStr Imatinib-resistance without BCR/ABL Point Mutation in Chronic Myeloid Leukemia
title_full_unstemmed Imatinib-resistance without BCR/ABL Point Mutation in Chronic Myeloid Leukemia
title_short Imatinib-resistance without BCR/ABL Point Mutation in Chronic Myeloid Leukemia
title_sort imatinib resistance without bcr abl point mutation in chronic myeloid leukemia
topic imatinib-resistance
cml
abl1 domain mutations
url https://caucasianmedj.com/articles/imatinib-resistance-without-bcrabl-point-mutation-in-chronic-myeloid-leukemia/doi/cmj.galenos.2024.36855
work_keys_str_mv AT aytanshirinova imatinibresistancewithoutbcrablpointmutationinchronicmyeloidleukemia