Comparison of passive ultrasonic and sonically activated irrigation methods: an investigation based on PGE2, NO and IL-6 levels
Abstract The effectiveness of Passive Ultrasonic Irrigation(PUI) and Sonically Activated Irrigation(SAI) techniques was investigated in apical periodontitis(AP) patients based on changes in prostaglandin E2(PGE2), nitric oxide(NO), and interleukin-6(IL-6) levels. Sixty-six AP patients and thirty hea...
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BMC
2025-07-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-025-06447-8 |
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| author | Seyda Ersahan Fatih Ozcelik Sertan Fındıkçı Yelda Erdem Hepsenoglu Duygu Degirmencioglu Aslı Usta |
| author_facet | Seyda Ersahan Fatih Ozcelik Sertan Fındıkçı Yelda Erdem Hepsenoglu Duygu Degirmencioglu Aslı Usta |
| author_sort | Seyda Ersahan |
| collection | DOAJ |
| description | Abstract The effectiveness of Passive Ultrasonic Irrigation(PUI) and Sonically Activated Irrigation(SAI) techniques was investigated in apical periodontitis(AP) patients based on changes in prostaglandin E2(PGE2), nitric oxide(NO), and interleukin-6(IL-6) levels. Sixty-six AP patients and thirty healthy controls were enrolled. Preoperative gingival crevicular fluid(preGCF) PGE2, NO and IL-6 levels were measured before treatment. After chemo-mechanical preparation, teeth were assigned into two groups according to final irrigation protocol[PUI(n:33) and SAI(n:33)]. The same markers were again measured 1 week after treatment(postGCF) and also 1st order most commonly seen bacteria(FMCB) typing was performed on microbial samples of the patients. PostGCF-PGE2 levels of the PUI group were lower than postGCF-PGE2 levels of the SAI group(p = 0.0335). Both postGCF-PE2 and IL-6 levels of the PUI group were significantly decreased after treatment(p < 0.0001), while only postGCF-PE2 levels decreased in the SAI group(p = 0.0316). The PUI system significantly reduced PGE2 and IL-6 levels by better controlling inflammation in the treatment of AP. |
| format | Article |
| id | doaj-art-d19be95fd3dd42cfb8e4334e7c55e702 |
| institution | Kabale University |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj-art-d19be95fd3dd42cfb8e4334e7c55e7022025-08-20T04:01:36ZengBMCBMC Oral Health1472-68312025-07-0125111310.1186/s12903-025-06447-8Comparison of passive ultrasonic and sonically activated irrigation methods: an investigation based on PGE2, NO and IL-6 levelsSeyda Ersahan0Fatih Ozcelik1Sertan Fındıkçı2Yelda Erdem Hepsenoglu3Duygu Degirmencioglu4Aslı Usta5Faculty of Dentistry, Department of Endodontics, Istanbul Medipol UniversityDepartment of Medical Biochemistry Department, Health Sciences University Sisli Hamidiye Etfal Training and Research HospitalFaculty of Dentistry, Department of Endodontics, Istanbul Medipol UniversityFaculty of Dentistry, Department of Endodontics, Istanbul Medipol UniversityFaculty of Dentistry, Department of Endodontics, Istanbul Medipol UniversityFaculty of Dentistry, Department of Endodontics, Istanbul Medipol UniversityAbstract The effectiveness of Passive Ultrasonic Irrigation(PUI) and Sonically Activated Irrigation(SAI) techniques was investigated in apical periodontitis(AP) patients based on changes in prostaglandin E2(PGE2), nitric oxide(NO), and interleukin-6(IL-6) levels. Sixty-six AP patients and thirty healthy controls were enrolled. Preoperative gingival crevicular fluid(preGCF) PGE2, NO and IL-6 levels were measured before treatment. After chemo-mechanical preparation, teeth were assigned into two groups according to final irrigation protocol[PUI(n:33) and SAI(n:33)]. The same markers were again measured 1 week after treatment(postGCF) and also 1st order most commonly seen bacteria(FMCB) typing was performed on microbial samples of the patients. PostGCF-PGE2 levels of the PUI group were lower than postGCF-PGE2 levels of the SAI group(p = 0.0335). Both postGCF-PE2 and IL-6 levels of the PUI group were significantly decreased after treatment(p < 0.0001), while only postGCF-PE2 levels decreased in the SAI group(p = 0.0316). The PUI system significantly reduced PGE2 and IL-6 levels by better controlling inflammation in the treatment of AP.https://doi.org/10.1186/s12903-025-06447-8Apical periodontitisPassive ultrasonic irrigationGingival crevicular fluidSonically activated irrigationPGE2IL-6 |
| spellingShingle | Seyda Ersahan Fatih Ozcelik Sertan Fındıkçı Yelda Erdem Hepsenoglu Duygu Degirmencioglu Aslı Usta Comparison of passive ultrasonic and sonically activated irrigation methods: an investigation based on PGE2, NO and IL-6 levels BMC Oral Health Apical periodontitis Passive ultrasonic irrigation Gingival crevicular fluid Sonically activated irrigation PGE2 IL-6 |
| title | Comparison of passive ultrasonic and sonically activated irrigation methods: an investigation based on PGE2, NO and IL-6 levels |
| title_full | Comparison of passive ultrasonic and sonically activated irrigation methods: an investigation based on PGE2, NO and IL-6 levels |
| title_fullStr | Comparison of passive ultrasonic and sonically activated irrigation methods: an investigation based on PGE2, NO and IL-6 levels |
| title_full_unstemmed | Comparison of passive ultrasonic and sonically activated irrigation methods: an investigation based on PGE2, NO and IL-6 levels |
| title_short | Comparison of passive ultrasonic and sonically activated irrigation methods: an investigation based on PGE2, NO and IL-6 levels |
| title_sort | comparison of passive ultrasonic and sonically activated irrigation methods an investigation based on pge2 no and il 6 levels |
| topic | Apical periodontitis Passive ultrasonic irrigation Gingival crevicular fluid Sonically activated irrigation PGE2 IL-6 |
| url | https://doi.org/10.1186/s12903-025-06447-8 |
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