Spatiotemporal profiling of protein kinase A activity in spontaneously beating hiPSC-derived cardiac organoids

Spatiotemporal profiling of protein kinase A activity in spontaneously beating hiPSC-derived cardiac organoids

Summary: Protein kinase A (PKA) phosphorylates proteins crucial for rhythm modulation, with its dysregulation linked to arrhythmias. This study investigated PKA activity’s spatiotemporal dynamics in spontaneously beating cardiac organoids. We hypothesized that PKA activity would respond to autonomic...

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Bibliographic Details
Main Authors: Ido Weiser-Bitoun, Savyon Mazgaoker, Rami Eid, Inbar Brosh, Yael Yaniv
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Cell biology
Stem cells research
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225002652
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