Case Report: Metastatic lung cancer in Meckel's Cave: a radiotherapy successful case and literature review
BackgroundMeckel’s cave (MC) is a highly uncommon site for metastatic disease, particularly from primary lung cancer.Case presentationWe report a clinical case of a 70-year-old man presenting with left trigeminal pain, left ptosis, and restricted abduction of the left eyeball. The patient had a 2-ye...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1613711/full |
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| author | Chao Chen Chao Chen Zhiqin Lu Gang Lin Yujie Hu Yong Guo |
| author_facet | Chao Chen Chao Chen Zhiqin Lu Gang Lin Yujie Hu Yong Guo |
| author_sort | Chao Chen |
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| description | BackgroundMeckel’s cave (MC) is a highly uncommon site for metastatic disease, particularly from primary lung cancer.Case presentationWe report a clinical case of a 70-year-old man presenting with left trigeminal pain, left ptosis, and restricted abduction of the left eyeball. The patient had a 2-year history of stage IV lung squamous cell carcinoma. Contrast-enhanced brain MRI and FDG-PET/CT showed an ill-defined mass with a heterogeneously enhancing lesion involving the left MC and middle cranial fossa. Stereotactic radiosurgery (SRS, 30 Gy/5 fx) achieved significant improvement in symptoms and regression of radiologic tumors within 1 month. Our review of relevant literature identified only two reported cases of lung adenocarcinoma metastasizing to MC. In addition, we examined the limited literature on other malignant tumors metastatic to MC managed with radiotherapy.ConclusionThis is the first reported case of MC metastasis from lung squamous cell carcinoma successfully treated with SRS. Effective management of MC metastasis requires histology-specific radiotherapy strategies, with squamous cell carcinoma benefiting from hypofractionated SRS. |
| format | Article |
| id | doaj-art-d1933d458bb1498c98f4629dbff324f5 |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-d1933d458bb1498c98f4629dbff324f52025-08-20T02:10:06ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-06-011510.3389/fonc.2025.16137111613711Case Report: Metastatic lung cancer in Meckel's Cave: a radiotherapy successful case and literature reviewChao Chen0Chao Chen1Zhiqin Lu2Gang Lin3Yujie Hu4Yong Guo5The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Radiotherapy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaDepartment of Radiotherapy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaDepartment of Radiotherapy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaDepartment of Radiotherapy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaDepartment of Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaBackgroundMeckel’s cave (MC) is a highly uncommon site for metastatic disease, particularly from primary lung cancer.Case presentationWe report a clinical case of a 70-year-old man presenting with left trigeminal pain, left ptosis, and restricted abduction of the left eyeball. The patient had a 2-year history of stage IV lung squamous cell carcinoma. Contrast-enhanced brain MRI and FDG-PET/CT showed an ill-defined mass with a heterogeneously enhancing lesion involving the left MC and middle cranial fossa. Stereotactic radiosurgery (SRS, 30 Gy/5 fx) achieved significant improvement in symptoms and regression of radiologic tumors within 1 month. Our review of relevant literature identified only two reported cases of lung adenocarcinoma metastasizing to MC. In addition, we examined the limited literature on other malignant tumors metastatic to MC managed with radiotherapy.ConclusionThis is the first reported case of MC metastasis from lung squamous cell carcinoma successfully treated with SRS. Effective management of MC metastasis requires histology-specific radiotherapy strategies, with squamous cell carcinoma benefiting from hypofractionated SRS.https://www.frontiersin.org/articles/10.3389/fonc.2025.1613711/fullMeckel’s cave metastasistrigeminal cave metastasislung cancerstereotactic radiosurgerycase report |
| spellingShingle | Chao Chen Chao Chen Zhiqin Lu Gang Lin Yujie Hu Yong Guo Case Report: Metastatic lung cancer in Meckel's Cave: a radiotherapy successful case and literature review Frontiers in Oncology Meckel’s cave metastasis trigeminal cave metastasis lung cancer stereotactic radiosurgery case report |
| title | Case Report: Metastatic lung cancer in Meckel's Cave: a radiotherapy successful case and literature review |
| title_full | Case Report: Metastatic lung cancer in Meckel's Cave: a radiotherapy successful case and literature review |
| title_fullStr | Case Report: Metastatic lung cancer in Meckel's Cave: a radiotherapy successful case and literature review |
| title_full_unstemmed | Case Report: Metastatic lung cancer in Meckel's Cave: a radiotherapy successful case and literature review |
| title_short | Case Report: Metastatic lung cancer in Meckel's Cave: a radiotherapy successful case and literature review |
| title_sort | case report metastatic lung cancer in meckel s cave a radiotherapy successful case and literature review |
| topic | Meckel’s cave metastasis trigeminal cave metastasis lung cancer stereotactic radiosurgery case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1613711/full |
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