Application of optical coherence tomography angiography to study retinal and choroidal vascular changes in patients with first-time coronary artery stenosis
Objective: To study the changes in retinal and choroidal vessels in patients with coronary artery stenosis via optical coherence tomography angiography (OCTA). Methods: A total of 100 subjects were enrolled in this study and divided into two groups: the observation group consisted of 50 patients wit...
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Elsevier
2025-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S157210002400471X |
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| author | Rongrong Guan Shuyan Qin Yezhu Chi Zhen Tang Haiyang Liu |
| author_facet | Rongrong Guan Shuyan Qin Yezhu Chi Zhen Tang Haiyang Liu |
| author_sort | Rongrong Guan |
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| description | Objective: To study the changes in retinal and choroidal vessels in patients with coronary artery stenosis via optical coherence tomography angiography (OCTA). Methods: A total of 100 subjects were enrolled in this study and divided into two groups: the observation group consisted of 50 patients with angina who were first diagnosed with coronary artery stenosis, and the control group consisted of 50 healthy adults without angina symptoms. All of the subjects underwent OCTA to investigate changes in retinochoroidal vessel density in patients with a first diagnosis of coronary artery stenosis. The parameters included superficial capillary plexus density (SCD), deep capillary plexus density (DCD), retinal peripapillary capillary plexus density(RPD), the choroidal vascular index (CVI), and the macular foveal avascular zone(FAZ area, perimeter, acircularity index, FD-300 vessel density). Results: SCD and DCD in the coronary artery stenosis group were lower than those in the control group (P = 0.045 and P = 0.034, respectively), the CVI was lower than that in the control group (P = 0.029), the FAZ perimeter and acircularity index were greater than those in the control group (P = 0.003,P = 0.024). Logistic regression and ROC curve analysis revealed that FAZ perimeter was the most significant risk factor for predicting coronary artery stenosis (P = 0.005, AUC = 0.664), and the cut-off value for FAZ perimeter was 2.065 mm. Conclusions: In patients with a first diagnosis of coronary artery stenosis, both retinal and choroidal blood flow are reduced. FAZ perimeter is a risk factor for predicting the occurrence of coronary artery stenosis. |
| format | Article |
| id | doaj-art-d1839128ad6c465d8c7b70cd79ea0c56 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
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| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-d1839128ad6c465d8c7b70cd79ea0c562025-02-01T04:11:42ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-02-0151104435Application of optical coherence tomography angiography to study retinal and choroidal vascular changes in patients with first-time coronary artery stenosisRongrong Guan0Shuyan Qin1Yezhu Chi2Zhen Tang3Haiyang Liu4The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, 269 Daxue Road, Tongshan District, Xuzhou 221116, China; The Affiliated Suqian Hospital of Xuzhou Medical University, 138, South Huanghe Road, Suqian City 223800, China; Xuzhou Medical University, 209 Tongshan Road, Yunlong District, Xuzhou 221004, ChinaThe Affiliated Suqian Hospital of Xuzhou Medical University, 138, South Huanghe Road, Suqian City 223800, China; Xuzhou Medical University, 209 Tongshan Road, Yunlong District, Xuzhou 221004, ChinaThe Affiliated Suqian Hospital of Xuzhou Medical University, 138, South Huanghe Road, Suqian City 223800, China; Xuzhou Medical University, 209 Tongshan Road, Yunlong District, Xuzhou 221004, ChinaThe Affiliated Suqian Hospital of Xuzhou Medical University, 138, South Huanghe Road, Suqian City 223800, China; Xuzhou Medical University, 209 Tongshan Road, Yunlong District, Xuzhou 221004, ChinaThe Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, 269 Daxue Road, Tongshan District, Xuzhou 221116, China; Eye Disease Prevention and Treatment Institute of Xuzhou, 269 Daxue Road, Tongshan District, Xuzhou 221116, China; Xuzhou Medical University, 209 Tongshan Road, Yunlong District, Xuzhou 221004, China; Corresponding author at: Department of Ophthalmology, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University/Xuzhou First People's Hospital/Eye Disease Prevention and Treatment Institute of Xuzhou, No. 269 Daxue Road, Tongshan District, Xuzhou 221116, China.Objective: To study the changes in retinal and choroidal vessels in patients with coronary artery stenosis via optical coherence tomography angiography (OCTA). Methods: A total of 100 subjects were enrolled in this study and divided into two groups: the observation group consisted of 50 patients with angina who were first diagnosed with coronary artery stenosis, and the control group consisted of 50 healthy adults without angina symptoms. All of the subjects underwent OCTA to investigate changes in retinochoroidal vessel density in patients with a first diagnosis of coronary artery stenosis. The parameters included superficial capillary plexus density (SCD), deep capillary plexus density (DCD), retinal peripapillary capillary plexus density(RPD), the choroidal vascular index (CVI), and the macular foveal avascular zone(FAZ area, perimeter, acircularity index, FD-300 vessel density). Results: SCD and DCD in the coronary artery stenosis group were lower than those in the control group (P = 0.045 and P = 0.034, respectively), the CVI was lower than that in the control group (P = 0.029), the FAZ perimeter and acircularity index were greater than those in the control group (P = 0.003,P = 0.024). Logistic regression and ROC curve analysis revealed that FAZ perimeter was the most significant risk factor for predicting coronary artery stenosis (P = 0.005, AUC = 0.664), and the cut-off value for FAZ perimeter was 2.065 mm. Conclusions: In patients with a first diagnosis of coronary artery stenosis, both retinal and choroidal blood flow are reduced. FAZ perimeter is a risk factor for predicting the occurrence of coronary artery stenosis.http://www.sciencedirect.com/science/article/pii/S157210002400471XOCTACoronary artery stenosisCoronary microcirculationRetinaChoroid |
| spellingShingle | Rongrong Guan Shuyan Qin Yezhu Chi Zhen Tang Haiyang Liu Application of optical coherence tomography angiography to study retinal and choroidal vascular changes in patients with first-time coronary artery stenosis Photodiagnosis and Photodynamic Therapy OCTA Coronary artery stenosis Coronary microcirculation Retina Choroid |
| title | Application of optical coherence tomography angiography to study retinal and choroidal vascular changes in patients with first-time coronary artery stenosis |
| title_full | Application of optical coherence tomography angiography to study retinal and choroidal vascular changes in patients with first-time coronary artery stenosis |
| title_fullStr | Application of optical coherence tomography angiography to study retinal and choroidal vascular changes in patients with first-time coronary artery stenosis |
| title_full_unstemmed | Application of optical coherence tomography angiography to study retinal and choroidal vascular changes in patients with first-time coronary artery stenosis |
| title_short | Application of optical coherence tomography angiography to study retinal and choroidal vascular changes in patients with first-time coronary artery stenosis |
| title_sort | application of optical coherence tomography angiography to study retinal and choroidal vascular changes in patients with first time coronary artery stenosis |
| topic | OCTA Coronary artery stenosis Coronary microcirculation Retina Choroid |
| url | http://www.sciencedirect.com/science/article/pii/S157210002400471X |
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