Association between genetic variants in hsa-miR-27a and hsa-miR-146a genes and male infertility
Background: miRNAs have enormous potential to be used as diagnostic and prognostic markers as well as therapeutic targets in male infertility and diseases of the reproductive system. This study aimed to investigate the association between the two functional genetic variants in the hsa-miR27a (rs2910...
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Society of Medical Biochemists of Serbia, Belgrade
2024-01-01
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| Series: | Journal of Medical Biochemistry |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582406936R.pdf |
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| author | Rajovski Srećko Matijašević-Joković Suzana Milanović Nikoleta Radovanović Nemanja Brkušanin Miloš Savić-Pavićević Dušanka Dobrijević Zorana Brajušković Goran |
| author_facet | Rajovski Srećko Matijašević-Joković Suzana Milanović Nikoleta Radovanović Nemanja Brkušanin Miloš Savić-Pavićević Dušanka Dobrijević Zorana Brajušković Goran |
| author_sort | Rajovski Srećko |
| collection | DOAJ |
| description | Background: miRNAs have enormous potential to be used as diagnostic and prognostic markers as well as therapeutic targets in male infertility and diseases of the reproductive system. This study aimed to investigate the association between the two functional genetic variants in the hsa-miR27a (rs2910164) and hsa-miR-146a gene (rs895819) and male infertility in North Macedonian population, as well as to test their association with the values of major seminal parameters. Methods: The case group included in this study comprised 158 men initially diagnosed with idiopathic male infertility. The control group included 126 age-matched healthy male volunteers who fathered at least one child. Results: We report the association of rs2910164 minor allele C for the first time with the increased susceptibility to asthenoteratozoospermia. Additionally, our results indicating the association of allele C with low sperm vitality are a novel finding. We did not demonstrate the association between genetic variant rs895819 and the risk of different types of male infertility. Still, the number of participants with CC genotype in subjects diagnosed with asthenoteratozoospermia was null, while in controls, it reached 7.2%. We further detected the rs895819 genotype-dependent difference in rapid progressive sperm motility. Conclusions: The association of rs2910164 and rs895819 with idiopathic male infertility in general is unlikely. However, both of these variants show an association with certain types of male infertility and with sperm abnormalities, which need to be confirmed in later studies in different ethnic groups. |
| format | Article |
| id | doaj-art-d180dead37ce46fca29f1187d9f812fe |
| institution | DOAJ |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj-art-d180dead37ce46fca29f1187d9f812fe2025-08-20T02:51:00ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662024-01-0143693694510.5937/jomb0-508761452-82582406936RAssociation between genetic variants in hsa-miR-27a and hsa-miR-146a genes and male infertilityRajovski Srećko0Matijašević-Joković Suzana1Milanović Nikoleta2Radovanović Nemanja3Brkušanin Miloš4https://orcid.org/0000-0002-4316-9231Savić-Pavićević Dušanka5https://orcid.org/0000-0002-2079-4077Dobrijević Zorana6Brajušković Goran7https://orcid.org/0000-0002-3935-6755Private Healthcare Institution Clinical Hospital "Acibadem Sistina", Skopje, North Macedoniauniversity of belgrade, faculty of biology, centre for human molecular genetic, Serbiauniversity of belgrade, faculty of biology, centre for human molecular genetic, Serbiauniversity of belgrade, faculty of biology, centre for human molecular genetic, Serbiauniversity of belgrade, faculty of biology, centre for human molecular genetic, Serbiauniversity of belgrade, faculty of biology, centre for human molecular genetic, SerbiaUniversity of Belgrade, Institute for the Application of Nuclear Energy - INEP, Department for Metabolism, Belgrade, Serbiauniversity of belgrade, faculty of biology, centre for human molecular genetic, SerbiaBackground: miRNAs have enormous potential to be used as diagnostic and prognostic markers as well as therapeutic targets in male infertility and diseases of the reproductive system. This study aimed to investigate the association between the two functional genetic variants in the hsa-miR27a (rs2910164) and hsa-miR-146a gene (rs895819) and male infertility in North Macedonian population, as well as to test their association with the values of major seminal parameters. Methods: The case group included in this study comprised 158 men initially diagnosed with idiopathic male infertility. The control group included 126 age-matched healthy male volunteers who fathered at least one child. Results: We report the association of rs2910164 minor allele C for the first time with the increased susceptibility to asthenoteratozoospermia. Additionally, our results indicating the association of allele C with low sperm vitality are a novel finding. We did not demonstrate the association between genetic variant rs895819 and the risk of different types of male infertility. Still, the number of participants with CC genotype in subjects diagnosed with asthenoteratozoospermia was null, while in controls, it reached 7.2%. We further detected the rs895819 genotype-dependent difference in rapid progressive sperm motility. Conclusions: The association of rs2910164 and rs895819 with idiopathic male infertility in general is unlikely. However, both of these variants show an association with certain types of male infertility and with sperm abnormalities, which need to be confirmed in later studies in different ethnic groups.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582406936R.pdfmale infertilityrs2910164rs895819polymorphismmir-27amir-146a |
| spellingShingle | Rajovski Srećko Matijašević-Joković Suzana Milanović Nikoleta Radovanović Nemanja Brkušanin Miloš Savić-Pavićević Dušanka Dobrijević Zorana Brajušković Goran Association between genetic variants in hsa-miR-27a and hsa-miR-146a genes and male infertility Journal of Medical Biochemistry male infertility rs2910164 rs895819 polymorphism mir-27a mir-146a |
| title | Association between genetic variants in hsa-miR-27a and hsa-miR-146a genes and male infertility |
| title_full | Association between genetic variants in hsa-miR-27a and hsa-miR-146a genes and male infertility |
| title_fullStr | Association between genetic variants in hsa-miR-27a and hsa-miR-146a genes and male infertility |
| title_full_unstemmed | Association between genetic variants in hsa-miR-27a and hsa-miR-146a genes and male infertility |
| title_short | Association between genetic variants in hsa-miR-27a and hsa-miR-146a genes and male infertility |
| title_sort | association between genetic variants in hsa mir 27a and hsa mir 146a genes and male infertility |
| topic | male infertility rs2910164 rs895819 polymorphism mir-27a mir-146a |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582406936R.pdf |
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