Function of specialized regulatory proteins and signaling pathways in exercise-induced muscle mitochondrial biogenesis
Skeletal muscle mitochondrial content and function are regulated by a number of specialized molecular pathways that remain to be fully defined. Although a number of proteins have been identified to be important for the maintenance of mitochondria in quiescent muscle, the requirement for these appear...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-09-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422016300336 |
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| author | Avigail T. Erlich Liam D. Tryon Matthew J. Crilly Jonathan M. Memme Zahra S. Mesbah Moosavi Ashley N. Oliveira Kaitlyn Beyfuss David A. Hood |
| author_facet | Avigail T. Erlich Liam D. Tryon Matthew J. Crilly Jonathan M. Memme Zahra S. Mesbah Moosavi Ashley N. Oliveira Kaitlyn Beyfuss David A. Hood |
| author_sort | Avigail T. Erlich |
| collection | DOAJ |
| description | Skeletal muscle mitochondrial content and function are regulated by a number of specialized molecular pathways that remain to be fully defined. Although a number of proteins have been identified to be important for the maintenance of mitochondria in quiescent muscle, the requirement for these appears to decrease with the activation of multiple overlapping signaling events that are triggered by exercise. This makes exercise a valuable therapeutic tool for the treatment of mitochondrially based metabolic disorders. In this review, we summarize some of the traditional and more recently appreciated pathways that are involved in mitochondrial biogenesis in muscle, particularly during exercise. |
| format | Article |
| id | doaj-art-d17e2bd310dd4084832f10b56220007d |
| institution | Kabale University |
| issn | 2213-4220 |
| language | English |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj-art-d17e2bd310dd4084832f10b56220007d2025-08-20T03:24:59ZengElsevierIntegrative Medicine Research2213-42202016-09-015318719710.1016/j.imr.2016.05.003Function of specialized regulatory proteins and signaling pathways in exercise-induced muscle mitochondrial biogenesisAvigail T. ErlichLiam D. TryonMatthew J. CrillyJonathan M. MemmeZahra S. Mesbah MoosaviAshley N. OliveiraKaitlyn BeyfussDavid A. HoodSkeletal muscle mitochondrial content and function are regulated by a number of specialized molecular pathways that remain to be fully defined. Although a number of proteins have been identified to be important for the maintenance of mitochondria in quiescent muscle, the requirement for these appears to decrease with the activation of multiple overlapping signaling events that are triggered by exercise. This makes exercise a valuable therapeutic tool for the treatment of mitochondrially based metabolic disorders. In this review, we summarize some of the traditional and more recently appreciated pathways that are involved in mitochondrial biogenesis in muscle, particularly during exercise.http://www.sciencedirect.com/science/article/pii/S2213422016300336mitochondrial protein importPGC-1alphaskeletal muscleunfolded protein response |
| spellingShingle | Avigail T. Erlich Liam D. Tryon Matthew J. Crilly Jonathan M. Memme Zahra S. Mesbah Moosavi Ashley N. Oliveira Kaitlyn Beyfuss David A. Hood Function of specialized regulatory proteins and signaling pathways in exercise-induced muscle mitochondrial biogenesis Integrative Medicine Research mitochondrial protein import PGC-1alpha skeletal muscle unfolded protein response |
| title | Function of specialized regulatory proteins and signaling pathways in exercise-induced muscle mitochondrial biogenesis |
| title_full | Function of specialized regulatory proteins and signaling pathways in exercise-induced muscle mitochondrial biogenesis |
| title_fullStr | Function of specialized regulatory proteins and signaling pathways in exercise-induced muscle mitochondrial biogenesis |
| title_full_unstemmed | Function of specialized regulatory proteins and signaling pathways in exercise-induced muscle mitochondrial biogenesis |
| title_short | Function of specialized regulatory proteins and signaling pathways in exercise-induced muscle mitochondrial biogenesis |
| title_sort | function of specialized regulatory proteins and signaling pathways in exercise induced muscle mitochondrial biogenesis |
| topic | mitochondrial protein import PGC-1alpha skeletal muscle unfolded protein response |
| url | http://www.sciencedirect.com/science/article/pii/S2213422016300336 |
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