Garlic and Onion Attenuates Vascular Inflammation and Oxidative Stress in Fructose-Fed Rats
This study evaluates the antioxidant and the anti-inflammatory properties of garlic (G) and onion (O) in fructose-fed rats (FFR). Thirty-day-old male Wistar rats were assigned to control (C), F (10% fructose in drinking water), F+T (tempol 1 mM as control antioxidant), F+G, and F+O. Aqueous G and O...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2011/475216 |
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| author | Marcela Alejandra Vazquez-Prieto Cecilia Rodriguez Lanzi Carina Lembo Claudio Rómulo Galmarini Roberto Miguel Miatello |
| author_facet | Marcela Alejandra Vazquez-Prieto Cecilia Rodriguez Lanzi Carina Lembo Claudio Rómulo Galmarini Roberto Miguel Miatello |
| author_sort | Marcela Alejandra Vazquez-Prieto |
| collection | DOAJ |
| description | This study evaluates the antioxidant and the anti-inflammatory properties of garlic (G) and onion (O) in fructose-fed rats (FFR). Thirty-day-old male Wistar rats were assigned to control (C), F (10% fructose in drinking water), F+T (tempol 1 mM as control antioxidant), F+G, and F+O. Aqueous G and O extracts were administered orally in doses of 150 and 400 mg/kg/d respectively, and along with tempol, were given during the last 8 weeks of a 14-week period. At the end of the study, FFR had developed insulin resistance, aortic NADPH oxidase activity, increased SBP, plasma TBARS and vascular cell adhesion molecule-1 (VCAM-1) expression in mesenteric arteries, and a decrease in heart endothelial nitric oxide synthase (eNOS). Garlic and onion administration to F rats reduced oxidative stress, increased eNOS activity, and also attenuated VCAM-1 expression. These results provide new evidence showing the anti-inflammatory and antioxidant effect of these vegetables. |
| format | Article |
| id | doaj-art-d17b37519cc24543a9233fd61c1195b7 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-d17b37519cc24543a9233fd61c1195b72025-02-03T01:24:13ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322011-01-01201110.1155/2011/475216475216Garlic and Onion Attenuates Vascular Inflammation and Oxidative Stress in Fructose-Fed RatsMarcela Alejandra Vazquez-Prieto0Cecilia Rodriguez Lanzi1Carina Lembo2Claudio Rómulo Galmarini3Roberto Miguel Miatello4Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Avenida Libertador 80, 5500 Mendoza, ArgentinaDepartamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Avenida Libertador 80, 5500 Mendoza, ArgentinaDepartamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Avenida Libertador 80, 5500 Mendoza, ArgentinaInstituto de Horticultura, Facultad de Ciencias Agrarias, Universidad Nacional de Cuyo, EEA INTA La Consulta y CONICET, Mendoza, ArgentinaDepartamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Avenida Libertador 80, 5500 Mendoza, ArgentinaThis study evaluates the antioxidant and the anti-inflammatory properties of garlic (G) and onion (O) in fructose-fed rats (FFR). Thirty-day-old male Wistar rats were assigned to control (C), F (10% fructose in drinking water), F+T (tempol 1 mM as control antioxidant), F+G, and F+O. Aqueous G and O extracts were administered orally in doses of 150 and 400 mg/kg/d respectively, and along with tempol, were given during the last 8 weeks of a 14-week period. At the end of the study, FFR had developed insulin resistance, aortic NADPH oxidase activity, increased SBP, plasma TBARS and vascular cell adhesion molecule-1 (VCAM-1) expression in mesenteric arteries, and a decrease in heart endothelial nitric oxide synthase (eNOS). Garlic and onion administration to F rats reduced oxidative stress, increased eNOS activity, and also attenuated VCAM-1 expression. These results provide new evidence showing the anti-inflammatory and antioxidant effect of these vegetables.http://dx.doi.org/10.1155/2011/475216 |
| spellingShingle | Marcela Alejandra Vazquez-Prieto Cecilia Rodriguez Lanzi Carina Lembo Claudio Rómulo Galmarini Roberto Miguel Miatello Garlic and Onion Attenuates Vascular Inflammation and Oxidative Stress in Fructose-Fed Rats Journal of Nutrition and Metabolism |
| title | Garlic and Onion Attenuates Vascular Inflammation and Oxidative Stress in Fructose-Fed Rats |
| title_full | Garlic and Onion Attenuates Vascular Inflammation and Oxidative Stress in Fructose-Fed Rats |
| title_fullStr | Garlic and Onion Attenuates Vascular Inflammation and Oxidative Stress in Fructose-Fed Rats |
| title_full_unstemmed | Garlic and Onion Attenuates Vascular Inflammation and Oxidative Stress in Fructose-Fed Rats |
| title_short | Garlic and Onion Attenuates Vascular Inflammation and Oxidative Stress in Fructose-Fed Rats |
| title_sort | garlic and onion attenuates vascular inflammation and oxidative stress in fructose fed rats |
| url | http://dx.doi.org/10.1155/2011/475216 |
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