Data from multi-national aging cohorts show dysregulated metabolic pathways in people with physio-cognitive decline

Abstract Background Physio-cognitive decline (PCD) represents a dual impairment of mobility and cognitive function in aging populations, significantly increasing risks of disability, dementia, and mortality. Despite its clinical importance, the underlying biological mechanisms driving PCD remain poo...

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Main Authors: Yi-Long Huang, Wei-Ju Chang, Chao-Hsiung Lin, Shu Zhang, Yukiko Nishita, Rei Otsuka, Wei-Ju Lee, Chih-Kuang Liang, Ming-Yueh Chou, Li-Ning Peng, Hidenori Arai, Luigi Ferrucci, Liang-Kung Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-01073-5
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