Cutaneous Granular Cell Tumor in a Middle-aged Woman: Clinicopathological Insights from a Rare Schwannian Neoplasm
We report the case of a 51-year-old female with an unusual presentation of a cutaneous granular cell tumor (GCT) on the lower back. The lesion was asymptomatic, well-defined, and firm, with an initial clinical differential of dermatofibroma, pilomatricoma, or leiomyoma. Histopathological examination...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-04-01
|
| Series: | Journal of Mid-Life Health |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jmh.jmh_62_25 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850086204958048256 |
|---|---|
| author | Seetu Palo Monica Mishra Kailas Anteshwar Mulsange |
| author_facet | Seetu Palo Monica Mishra Kailas Anteshwar Mulsange |
| author_sort | Seetu Palo |
| collection | DOAJ |
| description | We report the case of a 51-year-old female with an unusual presentation of a cutaneous granular cell tumor (GCT) on the lower back. The lesion was asymptomatic, well-defined, and firm, with an initial clinical differential of dermatofibroma, pilomatricoma, or leiomyoma. Histopathological examination revealed a dermal tumor composed of large polygonal cells with granular eosinophilic cytoplasm and uniform nuclei, without atypia or necrosis. Immunohistochemistry confirmed the diagnosis with strong S100 and CD68 positivity. Due to tumor extension tumor extension to the deep resection margin, close follow-up was advised. Accurate diagnosis of cutaneous GCTs relies on histopathology and immunohistochemistry, as clinical and dermoscopic findings are often nonspecific. Complete surgical excision is the primary treatment, with a generally favorable prognosis. Awareness of malignant potential and proper surgical management is crucial for optimal outcomes. |
| format | Article |
| id | doaj-art-d1740dc19d15499fbdc6cf189fbd3728 |
| institution | DOAJ |
| issn | 0976-7800 0976-7819 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Mid-Life Health |
| spelling | doaj-art-d1740dc19d15499fbdc6cf189fbd37282025-08-20T02:43:32ZengWolters Kluwer Medknow PublicationsJournal of Mid-Life Health0976-78000976-78192025-04-0116221822010.4103/jmh.jmh_62_25Cutaneous Granular Cell Tumor in a Middle-aged Woman: Clinicopathological Insights from a Rare Schwannian NeoplasmSeetu PaloMonica MishraKailas Anteshwar MulsangeWe report the case of a 51-year-old female with an unusual presentation of a cutaneous granular cell tumor (GCT) on the lower back. The lesion was asymptomatic, well-defined, and firm, with an initial clinical differential of dermatofibroma, pilomatricoma, or leiomyoma. Histopathological examination revealed a dermal tumor composed of large polygonal cells with granular eosinophilic cytoplasm and uniform nuclei, without atypia or necrosis. Immunohistochemistry confirmed the diagnosis with strong S100 and CD68 positivity. Due to tumor extension tumor extension to the deep resection margin, close follow-up was advised. Accurate diagnosis of cutaneous GCTs relies on histopathology and immunohistochemistry, as clinical and dermoscopic findings are often nonspecific. Complete surgical excision is the primary treatment, with a generally favorable prognosis. Awareness of malignant potential and proper surgical management is crucial for optimal outcomes.https://journals.lww.com/10.4103/jmh.jmh_62_25benigncutaneousgranular cell tumorimmunohistochemistry |
| spellingShingle | Seetu Palo Monica Mishra Kailas Anteshwar Mulsange Cutaneous Granular Cell Tumor in a Middle-aged Woman: Clinicopathological Insights from a Rare Schwannian Neoplasm Journal of Mid-Life Health benign cutaneous granular cell tumor immunohistochemistry |
| title | Cutaneous Granular Cell Tumor in a Middle-aged Woman: Clinicopathological Insights from a Rare Schwannian Neoplasm |
| title_full | Cutaneous Granular Cell Tumor in a Middle-aged Woman: Clinicopathological Insights from a Rare Schwannian Neoplasm |
| title_fullStr | Cutaneous Granular Cell Tumor in a Middle-aged Woman: Clinicopathological Insights from a Rare Schwannian Neoplasm |
| title_full_unstemmed | Cutaneous Granular Cell Tumor in a Middle-aged Woman: Clinicopathological Insights from a Rare Schwannian Neoplasm |
| title_short | Cutaneous Granular Cell Tumor in a Middle-aged Woman: Clinicopathological Insights from a Rare Schwannian Neoplasm |
| title_sort | cutaneous granular cell tumor in a middle aged woman clinicopathological insights from a rare schwannian neoplasm |
| topic | benign cutaneous granular cell tumor immunohistochemistry |
| url | https://journals.lww.com/10.4103/jmh.jmh_62_25 |
| work_keys_str_mv | AT seetupalo cutaneousgranularcelltumorinamiddleagedwomanclinicopathologicalinsightsfromarareschwannianneoplasm AT monicamishra cutaneousgranularcelltumorinamiddleagedwomanclinicopathologicalinsightsfromarareschwannianneoplasm AT kailasanteshwarmulsange cutaneousgranularcelltumorinamiddleagedwomanclinicopathologicalinsightsfromarareschwannianneoplasm |