Impact of anti-VZV IgG levels on Parkinson’s disease risk and progression: a Mendelian randomization analysis

Impact of anti-VZV IgG levels on Parkinson’s disease risk and progression: a Mendelian randomization analysis

Abstract Research suggests a potential link between varicella zoster virus (VZV) and Parkinson’s disease (PD), but the causal relationship between anti-VZV IgG levels and PD is not well understood. Using two-sample Mendelian Randomization (MR), we assessed the causal impact of anti-VZV IgG levels on...

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Main Authors: Jinxing Sun, Xiangchen Li, Shengmei Ma, Haopeng Lin, Zhenke Li, Junheng Jia, Yasaman Alizadeh, Qianqian Wu, Ying Hou, Hong Wang, Qi Wang, Guangjian Zhang, Xingang Li, Weiguo Li, Chao Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Parkinson’s disease
Mendelian randomization
VZV
Anti-VZV IgG levels
Online Access:https://doi.org/10.1038/s41598-025-96382-z
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Summary:Abstract Research suggests a potential link between varicella zoster virus (VZV) and Parkinson’s disease (PD), but the causal relationship between anti-VZV IgG levels and PD is not well understood. Using two-sample Mendelian Randomization (MR), we assessed the causal impact of anti-VZV IgG levels on PD risk and progression. Our study found a significant association between higher anti-VZV IgG levels and an increased risk of PD. For PD progression, higher anti-VZV IgG levels were linked to a greater risk of constipation, insomnia, and Restless Legs. These findings remained consistent after sensitivity analyses. In conclusion, our study suggests that elevated anti-VZV IgG levels may contribute to an increased risk and progression of PD, supporting a potential causal link that warrants further mechanistic investigation.
ISSN:2045-2322

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