IFNβ drives ferroptosis through elevating TRIM22 and promotes the cytotoxicity of RSL3

IFNβ drives ferroptosis through elevating TRIM22 and promotes the cytotoxicity of RSL3

BackgroundCyclic GMP-AMP synthase (cGAS)-stimulator-of-interferon genes (STING) pathway is a cytosolic DNA sensor system. The production of this pathway, interferon-β (IFNβ), could suppress the growth of tumor cells, yet it is unclear whether ferroptosis is involved in IFNβ-induced cell death.Method...

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Bibliographic Details
Main Authors: Huiyue Dong, Ling Zhu, Jingjing Sun, Qiuyan Chen, Pengyang Liu, Wei Zhang, Huajing Zeng, Rong Lin, Zongyang Yu, Jun Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
IFNβ
ferroptosis
cGAS-STING
TRIM22
RSL3
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1535554/full
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