Alleviating rheumatoid arthritis with a photo-pharmacotherapeutic glycan-integrated nanogel complex for advanced percutaneous delivery
Abstract The prospective of percutaneous drug delivery (PDD) mechanisms to address the limitations of oral and injectable treatment for rheumatoid arthritis (RA) is increasing. These limitations encompass inadequate compliance among patients and acute gastrointestinal side effects. However, the skin...
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BMC
2024-10-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-024-02877-8 |
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| author | Pei-Wei Weng Hsien-Tsung Lu Lekshmi Rethi Chia-Hung Liu Chin-Chean Wong Lekha Rethi Kevin C.-W. Wu Pei-Ru Jheng Hieu T. Nguyen Andrew E.-Y. Chuang |
| author_facet | Pei-Wei Weng Hsien-Tsung Lu Lekshmi Rethi Chia-Hung Liu Chin-Chean Wong Lekha Rethi Kevin C.-W. Wu Pei-Ru Jheng Hieu T. Nguyen Andrew E.-Y. Chuang |
| author_sort | Pei-Wei Weng |
| collection | DOAJ |
| description | Abstract The prospective of percutaneous drug delivery (PDD) mechanisms to address the limitations of oral and injectable treatment for rheumatoid arthritis (RA) is increasing. These limitations encompass inadequate compliance among patients and acute gastrointestinal side effects. However, the skin’s intrinsic layer can frequently hinder the percutaneous dispersion of RA medications, thus mitigating the efficiency of drug delivery. To circumvent this constraint, we developed a strontium ranelate (SrR)-loaded alginate (ALG) phototherapeutic hydrogel to assess its effectiveness in combating RA. Our studies revealed that this SrR-loaded ALG hydrogel incorporating photoelectrically responsive molybdenum disulfide nanoflowers (MoS2 NFs) and photothermally responsive polypyrrole nanoparticles (Ppy NPs) to form ALG@SrR-MoS2 NFs-Ppy NPs demonstrated substantial mechanical strength, potentially enabling delivery of hydrophilic therapeutic agents into the skin and significantly impeding the progression of RA. Comprehensive biochemical, histological, behavioral, and radiographic analyses in an animal model of zymosan-induced RA demonstrated that the application of these phototherapeutic ALG@SrR-MoS2 NFs-Ppy NPs effectively reduced inflammation, increased the presence of heat shock proteins, regulatory cluster of differentiation M2 macrophages, and alleviated joint degeneration associated with RA. As demonstrated by our findings, treating RA and possibly other autoimmune disorders with this phototherapeutic hydrogel system offers a distinctive, highly compliant, and therapeutically efficient method. |
| format | Article |
| id | doaj-art-d166ec976db747b5b86ee34831a4b13c |
| institution | OA Journals |
| issn | 1477-3155 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-d166ec976db747b5b86ee34831a4b13c2025-08-20T02:11:54ZengBMCJournal of Nanobiotechnology1477-31552024-10-0122112710.1186/s12951-024-02877-8Alleviating rheumatoid arthritis with a photo-pharmacotherapeutic glycan-integrated nanogel complex for advanced percutaneous deliveryPei-Wei Weng0Hsien-Tsung Lu1Lekshmi Rethi2Chia-Hung Liu3Chin-Chean Wong4Lekha Rethi5Kevin C.-W. Wu6Pei-Ru Jheng7Hieu T. Nguyen8Andrew E.-Y. Chuang9Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical UniversityDepartment of Orthopedics, School of Medicine, College of Medicine, Taipei Medical UniversityGraduate Institute of Biomedical Materials and Tissue Engineering, Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical UniversityDepartment of Urology, School of Medicine, College of Medicine, Taipei Medical UniversityDepartment of Orthopedics, School of Medicine, College of Medicine, Taipei Medical UniversityDepartment of Orthopedics, Shuang Ho Hospital, Taipei Medical UniversityInstitute of Biomedical Engineering and Nanomedicine, National Health Research InstituteGraduate Institute of Biomedical Materials and Tissue Engineering, Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical UniversityDepartment of Orthopedics and Trauma, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh CityGraduate Institute of Biomedical Materials and Tissue Engineering, Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical UniversityAbstract The prospective of percutaneous drug delivery (PDD) mechanisms to address the limitations of oral and injectable treatment for rheumatoid arthritis (RA) is increasing. These limitations encompass inadequate compliance among patients and acute gastrointestinal side effects. However, the skin’s intrinsic layer can frequently hinder the percutaneous dispersion of RA medications, thus mitigating the efficiency of drug delivery. To circumvent this constraint, we developed a strontium ranelate (SrR)-loaded alginate (ALG) phototherapeutic hydrogel to assess its effectiveness in combating RA. Our studies revealed that this SrR-loaded ALG hydrogel incorporating photoelectrically responsive molybdenum disulfide nanoflowers (MoS2 NFs) and photothermally responsive polypyrrole nanoparticles (Ppy NPs) to form ALG@SrR-MoS2 NFs-Ppy NPs demonstrated substantial mechanical strength, potentially enabling delivery of hydrophilic therapeutic agents into the skin and significantly impeding the progression of RA. Comprehensive biochemical, histological, behavioral, and radiographic analyses in an animal model of zymosan-induced RA demonstrated that the application of these phototherapeutic ALG@SrR-MoS2 NFs-Ppy NPs effectively reduced inflammation, increased the presence of heat shock proteins, regulatory cluster of differentiation M2 macrophages, and alleviated joint degeneration associated with RA. As demonstrated by our findings, treating RA and possibly other autoimmune disorders with this phototherapeutic hydrogel system offers a distinctive, highly compliant, and therapeutically efficient method.https://doi.org/10.1186/s12951-024-02877-8PhototherapyPolypyrroleMolybdenum disulfideRheumatoid arthritisImmunomodulation |
| spellingShingle | Pei-Wei Weng Hsien-Tsung Lu Lekshmi Rethi Chia-Hung Liu Chin-Chean Wong Lekha Rethi Kevin C.-W. Wu Pei-Ru Jheng Hieu T. Nguyen Andrew E.-Y. Chuang Alleviating rheumatoid arthritis with a photo-pharmacotherapeutic glycan-integrated nanogel complex for advanced percutaneous delivery Journal of Nanobiotechnology Phototherapy Polypyrrole Molybdenum disulfide Rheumatoid arthritis Immunomodulation |
| title | Alleviating rheumatoid arthritis with a photo-pharmacotherapeutic glycan-integrated nanogel complex for advanced percutaneous delivery |
| title_full | Alleviating rheumatoid arthritis with a photo-pharmacotherapeutic glycan-integrated nanogel complex for advanced percutaneous delivery |
| title_fullStr | Alleviating rheumatoid arthritis with a photo-pharmacotherapeutic glycan-integrated nanogel complex for advanced percutaneous delivery |
| title_full_unstemmed | Alleviating rheumatoid arthritis with a photo-pharmacotherapeutic glycan-integrated nanogel complex for advanced percutaneous delivery |
| title_short | Alleviating rheumatoid arthritis with a photo-pharmacotherapeutic glycan-integrated nanogel complex for advanced percutaneous delivery |
| title_sort | alleviating rheumatoid arthritis with a photo pharmacotherapeutic glycan integrated nanogel complex for advanced percutaneous delivery |
| topic | Phototherapy Polypyrrole Molybdenum disulfide Rheumatoid arthritis Immunomodulation |
| url | https://doi.org/10.1186/s12951-024-02877-8 |
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