Spontaneous ovarian hyperstimulation syndrome mimicking ovarian cancer in a nonpregnant woman: A case report and literature review

Spontaneous ovarian hyperstimulation syndrome is an extremely rare condition, especially in nonpregnant women who do not exhibit exogenous ovarian stimulation. Herein, we present a case of spontaneous ovarian hyperstimulation syndrome in a 28-year-old nonpregnant woman who presented with life-threat...

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Main Authors: Setare Akhavan, Morteza Daraei, Faeze Salahshour, Mina Sadat Mosavat
Format: Article
Language:English
Published: SAGE Publishing 2025-04-01
Series:Journal of International Medical Research
Online Access:https://doi.org/10.1177/03000605251332908
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author Setare Akhavan
Morteza Daraei
Faeze Salahshour
Mina Sadat Mosavat
author_facet Setare Akhavan
Morteza Daraei
Faeze Salahshour
Mina Sadat Mosavat
author_sort Setare Akhavan
collection DOAJ
description Spontaneous ovarian hyperstimulation syndrome is an extremely rare condition, especially in nonpregnant women who do not exhibit exogenous ovarian stimulation. Herein, we present a case of spontaneous ovarian hyperstimulation syndrome in a 28-year-old nonpregnant woman who presented with life-threatening multiorgan dysfunction. Initial imaging studies and tumor marker assessment suggested the presence of a malignant ovarian tumor, posing substantial diagnostic challenges. The patient underwent emergency surgery due to severe hemorrhagic shock. Intraoperative findings revealed irregular and deformed ovaries; however, histologic examination showed luteinizing hemorrhagic cysts, leading to a diagnosis of spontaneous ovarian hyperstimulation syndrome. This case highlights the importance of considering spontaneous ovarian hyperstimulation syndrome in the differential diagnosis of ovarian enlargement with ascites, even in the absence of pregnancy or ovarian stimulation. It also underscores the critical role of expert radiological interpretation in such complex cases.
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institution Kabale University
issn 1473-2300
language English
publishDate 2025-04-01
publisher SAGE Publishing
record_format Article
series Journal of International Medical Research
spelling doaj-art-d15a557d2ee9422282b65be42f1acd0f2025-08-20T03:48:31ZengSAGE PublishingJournal of International Medical Research1473-23002025-04-015310.1177/03000605251332908Spontaneous ovarian hyperstimulation syndrome mimicking ovarian cancer in a nonpregnant woman: A case report and literature reviewSetare AkhavanMorteza DaraeiFaeze SalahshourMina Sadat MosavatSpontaneous ovarian hyperstimulation syndrome is an extremely rare condition, especially in nonpregnant women who do not exhibit exogenous ovarian stimulation. Herein, we present a case of spontaneous ovarian hyperstimulation syndrome in a 28-year-old nonpregnant woman who presented with life-threatening multiorgan dysfunction. Initial imaging studies and tumor marker assessment suggested the presence of a malignant ovarian tumor, posing substantial diagnostic challenges. The patient underwent emergency surgery due to severe hemorrhagic shock. Intraoperative findings revealed irregular and deformed ovaries; however, histologic examination showed luteinizing hemorrhagic cysts, leading to a diagnosis of spontaneous ovarian hyperstimulation syndrome. This case highlights the importance of considering spontaneous ovarian hyperstimulation syndrome in the differential diagnosis of ovarian enlargement with ascites, even in the absence of pregnancy or ovarian stimulation. It also underscores the critical role of expert radiological interpretation in such complex cases.https://doi.org/10.1177/03000605251332908
spellingShingle Setare Akhavan
Morteza Daraei
Faeze Salahshour
Mina Sadat Mosavat
Spontaneous ovarian hyperstimulation syndrome mimicking ovarian cancer in a nonpregnant woman: A case report and literature review
Journal of International Medical Research
title Spontaneous ovarian hyperstimulation syndrome mimicking ovarian cancer in a nonpregnant woman: A case report and literature review
title_full Spontaneous ovarian hyperstimulation syndrome mimicking ovarian cancer in a nonpregnant woman: A case report and literature review
title_fullStr Spontaneous ovarian hyperstimulation syndrome mimicking ovarian cancer in a nonpregnant woman: A case report and literature review
title_full_unstemmed Spontaneous ovarian hyperstimulation syndrome mimicking ovarian cancer in a nonpregnant woman: A case report and literature review
title_short Spontaneous ovarian hyperstimulation syndrome mimicking ovarian cancer in a nonpregnant woman: A case report and literature review
title_sort spontaneous ovarian hyperstimulation syndrome mimicking ovarian cancer in a nonpregnant woman a case report and literature review
url https://doi.org/10.1177/03000605251332908
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AT faezesalahshour spontaneousovarianhyperstimulationsyndromemimickingovariancancerinanonpregnantwomanacasereportandliteraturereview
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