Effects of High-Resolution Natural Sound with Inaudible High-Frequency Components on Healing, Symptoms, and Sleep Satisfaction in Terminally Ill Cancer Patients
Objectives: This study aimed to assess the effects of high-resolution natural sound with inaudible high-frequency components (HNIH) on healing, symptoms, sleep satisfaction, and autonomic nerve function among terminally ill cancer patients. Methods: We conducted a single-arm, open-label study of 4-h...
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Mary Ann Liebert
2025-01-01
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| Series: | Palliative Medicine Reports |
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| Online Access: | https://www.liebertpub.com/doi/10.1089/pmr.2024.0089 |
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| author | Yasutaka Shimotsuura Keisuke Ishizuka Takashi Kawaguchi Kazue Umetsu Mariko Harada Yujiro Inoue Emi Kubo Kazuhiro Kosugi Takashi Igarashi Seiya Enomoto Hidehiko Taniyama Tetsuo Iwata Takuhiro Yamaguchi Yoshihisa Matsumoto Tomofumi Miura |
| author_facet | Yasutaka Shimotsuura Keisuke Ishizuka Takashi Kawaguchi Kazue Umetsu Mariko Harada Yujiro Inoue Emi Kubo Kazuhiro Kosugi Takashi Igarashi Seiya Enomoto Hidehiko Taniyama Tetsuo Iwata Takuhiro Yamaguchi Yoshihisa Matsumoto Tomofumi Miura |
| author_sort | Yasutaka Shimotsuura |
| collection | DOAJ |
| description | Objectives: This study aimed to assess the effects of high-resolution natural sound with inaudible high-frequency components (HNIH) on healing, symptoms, sleep satisfaction, and autonomic nerve function among terminally ill cancer patients. Methods: We conducted a single-arm, open-label study of 4-hour HNIH for 20 terminally ill cancer patients. We evaluated the healing state, symptoms (Japanese version of the Edmonton Symptom Assessment System-Revised, ESAS-r-J), global impression, and heart rate variability at 30 minutes (T2) and 4 hours (T3) after starting HNIH and sleep satisfaction the next morning (T4). Results: A total of 18 participants were evaluated (mean age: 69.4 years; 33.3% female). Post-intervention, there was a nonsignificant increase in Healing Scale scores at T2 (mean difference: 5.3, 95% confidence interval [CI]: −1.2 to 11.8, p = 0.106), but a significant increase at T3 (mean difference: 6.6, 95% CI: 1.0 to 12.3, p = 0.024). Specific ESAS-r-J scores demonstrated significant improvements in anxiety (mean difference at T2: −1.2, 95% CI: −1.99 to −0.34, p = 0.008; T3: −1.2, 95% CI: −1.99 to −0.34, p = 0.008), tiredness (mean difference at T2: −0.6, 95% CI: −1.18 to −0.04, p = 0.037), and shortness of breath (mean difference at T2: −1.0, 95% CI: −1.72 to −0.28, p = 0.010). Moreover, 66.7% of participants reported improved general conditions at T2 and T3, whereas 50% reported enhanced sleep satisfaction at T4. Heart rate variability analysis revealed a decreased low-frequency/high-frequency ratio in 55.6% of participants at T2 and 44.4% at T3. Conclusions: The present single-arm study showed that HNIH potentially enhanced healing, alleviated symptoms such as anxiety, tiredness, and shortness of breath, and improved sleep satisfaction in terminally ill cancer patients. |
| format | Article |
| id | doaj-art-d156afd8f1304382bc0640c0f8ea3ab7 |
| institution | OA Journals |
| issn | 2689-2820 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Mary Ann Liebert |
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| series | Palliative Medicine Reports |
| spelling | doaj-art-d156afd8f1304382bc0640c0f8ea3ab72025-08-20T02:30:49ZengMary Ann LiebertPalliative Medicine Reports2689-28202025-01-0161536010.1089/pmr.2024.0089Effects of High-Resolution Natural Sound with Inaudible High-Frequency Components on Healing, Symptoms, and Sleep Satisfaction in Terminally Ill Cancer PatientsYasutaka Shimotsuura0Keisuke Ishizuka1Takashi Kawaguchi2Kazue Umetsu3Mariko Harada4Yujiro Inoue5Emi Kubo6Kazuhiro Kosugi7Takashi Igarashi8Seiya Enomoto9Hidehiko Taniyama10Tetsuo Iwata11Takuhiro Yamaguchi12Yoshihisa Matsumoto13Tomofumi Miura14Department of Palliative Medicine, National Cancer Center Hospital East, Kashiwa, Japan.Department of Palliative Medicine, National Cancer Center Hospital East, Kashiwa, Japan.Department of Clinical Assessment, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.Department of Palliative Medicine, National Cancer Center Hospital East, Kashiwa, Japan.Department of Palliative Medicine, National Cancer Center Hospital East, Kashiwa, Japan.Department of Palliative Medicine, National Cancer Center Hospital East, Kashiwa, Japan.Department of Palliative Medicine, National Cancer Center Hospital East, Kashiwa, Japan.Department of Palliative Medicine, National Cancer Center Hospital East, Kashiwa, Japan.Department of Pharmacy, National Cancer Center Hospital East, Kashiwa, Japan.JVCKENWOOD Corporation, Yokohama, Japan.JVCKENWOOD Corporation, Yokohama, Japan.JVCKENWOOD Corporation, Yokohama, Japan.Division of Biostatistics, Tohoku University Graduate School of Medicine, Sendai, Japan.Department of Palliative Medicine, National Cancer Center Hospital East, Kashiwa, Japan.Department of Palliative Medicine, National Cancer Center Hospital East, Kashiwa, Japan.Objectives: This study aimed to assess the effects of high-resolution natural sound with inaudible high-frequency components (HNIH) on healing, symptoms, sleep satisfaction, and autonomic nerve function among terminally ill cancer patients. Methods: We conducted a single-arm, open-label study of 4-hour HNIH for 20 terminally ill cancer patients. We evaluated the healing state, symptoms (Japanese version of the Edmonton Symptom Assessment System-Revised, ESAS-r-J), global impression, and heart rate variability at 30 minutes (T2) and 4 hours (T3) after starting HNIH and sleep satisfaction the next morning (T4). Results: A total of 18 participants were evaluated (mean age: 69.4 years; 33.3% female). Post-intervention, there was a nonsignificant increase in Healing Scale scores at T2 (mean difference: 5.3, 95% confidence interval [CI]: −1.2 to 11.8, p = 0.106), but a significant increase at T3 (mean difference: 6.6, 95% CI: 1.0 to 12.3, p = 0.024). Specific ESAS-r-J scores demonstrated significant improvements in anxiety (mean difference at T2: −1.2, 95% CI: −1.99 to −0.34, p = 0.008; T3: −1.2, 95% CI: −1.99 to −0.34, p = 0.008), tiredness (mean difference at T2: −0.6, 95% CI: −1.18 to −0.04, p = 0.037), and shortness of breath (mean difference at T2: −1.0, 95% CI: −1.72 to −0.28, p = 0.010). Moreover, 66.7% of participants reported improved general conditions at T2 and T3, whereas 50% reported enhanced sleep satisfaction at T4. Heart rate variability analysis revealed a decreased low-frequency/high-frequency ratio in 55.6% of participants at T2 and 44.4% at T3. Conclusions: The present single-arm study showed that HNIH potentially enhanced healing, alleviated symptoms such as anxiety, tiredness, and shortness of breath, and improved sleep satisfaction in terminally ill cancer patients.https://www.liebertpub.com/doi/10.1089/pmr.2024.0089cancerhealinghigh-resolution natural music with inaudible high-frequency componentsmusicpalliative care |
| spellingShingle | Yasutaka Shimotsuura Keisuke Ishizuka Takashi Kawaguchi Kazue Umetsu Mariko Harada Yujiro Inoue Emi Kubo Kazuhiro Kosugi Takashi Igarashi Seiya Enomoto Hidehiko Taniyama Tetsuo Iwata Takuhiro Yamaguchi Yoshihisa Matsumoto Tomofumi Miura Effects of High-Resolution Natural Sound with Inaudible High-Frequency Components on Healing, Symptoms, and Sleep Satisfaction in Terminally Ill Cancer Patients Palliative Medicine Reports cancer healing high-resolution natural music with inaudible high-frequency components music palliative care |
| title | Effects of High-Resolution Natural Sound with Inaudible High-Frequency Components on Healing, Symptoms, and Sleep Satisfaction in Terminally Ill Cancer Patients |
| title_full | Effects of High-Resolution Natural Sound with Inaudible High-Frequency Components on Healing, Symptoms, and Sleep Satisfaction in Terminally Ill Cancer Patients |
| title_fullStr | Effects of High-Resolution Natural Sound with Inaudible High-Frequency Components on Healing, Symptoms, and Sleep Satisfaction in Terminally Ill Cancer Patients |
| title_full_unstemmed | Effects of High-Resolution Natural Sound with Inaudible High-Frequency Components on Healing, Symptoms, and Sleep Satisfaction in Terminally Ill Cancer Patients |
| title_short | Effects of High-Resolution Natural Sound with Inaudible High-Frequency Components on Healing, Symptoms, and Sleep Satisfaction in Terminally Ill Cancer Patients |
| title_sort | effects of high resolution natural sound with inaudible high frequency components on healing symptoms and sleep satisfaction in terminally ill cancer patients |
| topic | cancer healing high-resolution natural music with inaudible high-frequency components music palliative care |
| url | https://www.liebertpub.com/doi/10.1089/pmr.2024.0089 |
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