OCRClassifier: integrating statistical control chart into machine learning framework for better detecting open chromatin regions

OCRClassifier: integrating statistical control chart into machine learning framework for better detecting open chromatin regions

Open chromatin regions (OCRs) play a crucial role in transcriptional regulation and gene expression. In recent years, there has been a growing interest in using plasma cell-free DNA (cfDNA) sequencing data to detect OCRs. By analyzing the characteristics of cfDNA fragments and their sequencing cover...

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Bibliographic Details
Main Authors: Xin Lai, Min Liu, Yuqian Liu, Xiaoyan Zhu, Jiayin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Genetics
Subjects:
cell-free DNA
open chromatin region
sequencing data analysis
machine learning approach
multivariate control chart
noisy label
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2024.1400228/full
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