Sulfatase 2 inhibition sensitizes triple-negative breast cancer cells to paclitaxel through augmentation of extracellular ATP

Sulfatase 2 inhibition sensitizes triple-negative breast cancer cells to paclitaxel through augmentation of extracellular ATP

The highest incidence and cancer-related mortality rate among women worldwide is due to breast cancer. Triple-negative breast cancers (TNBC) are associated with more inferior outcomes than other breast cancers because of their progressive nature and the deficit in available therapies. Therefore, the...

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Bibliographic Details
Main Authors: Jasmine M. Manouchehri, Jharna Datta, Lynn M. Marcho, Daniel Stover, Ramesh K. Ganju, Bhuvaneswari Ramaswamy, William E. Carson, Arjun Mittra, Xiaoli Zhang, Patrick M. Schnell, Yu Yue, Mark P. Rubinstein, Mathew A. Cherian
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Cancer Biology & Therapy
Subjects:
Chemotherapy
breast cancer
sulfatases
ATP
purinergic signaling
heparan sodium sulfate
Online Access:https://www.tandfonline.com/doi/10.1080/15384047.2025.2483989
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