Establishment of human induced pluripotent stem cell line BAFYi001-A from a patient with Edwards syndrome
Edwards’ syndrome (trisomy 18) is a genetic disorder characterized by the presence of an extra chromosome 18. A specific induced pluripotent stem cell (iPSC) line, named BAFYi001-A, was generated from the umbilical cord-derived mesenchymal stromal cells (UC-MSCs) of a patient with Edwards syndrome u...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506125000856 |
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| author | Qingqing Yang Simin Liu Jing Ruan Bo Sun Xiaoyan Chen Xingqiang Lai |
| author_facet | Qingqing Yang Simin Liu Jing Ruan Bo Sun Xiaoyan Chen Xingqiang Lai |
| author_sort | Qingqing Yang |
| collection | DOAJ |
| description | Edwards’ syndrome (trisomy 18) is a genetic disorder characterized by the presence of an extra chromosome 18. A specific induced pluripotent stem cell (iPSC) line, named BAFYi001-A, was generated from the umbilical cord-derived mesenchymal stromal cells (UC-MSCs) of a patient with Edwards syndrome using an integration-free Sendai virus method. This line expresses markers for identifying undifferentiated hiPSCs, trilineage differentiation potential, and genetic fidelity in the context of trisomy 18. Therefore, this cell line serves as a reliable in vitro model for investigating the pathogenesis of Edward syndrome. |
| format | Article |
| id | doaj-art-d14e5280a02242ed8ab3de66d7df23cc |
| institution | Kabale University |
| issn | 1873-5061 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj-art-d14e5280a02242ed8ab3de66d7df23cc2025-08-20T03:46:49ZengElsevierStem Cell Research1873-50612025-08-018610373510.1016/j.scr.2025.103735Establishment of human induced pluripotent stem cell line BAFYi001-A from a patient with Edwards syndromeQingqing Yang0Simin Liu1Jing Ruan2Bo Sun3Xiaoyan Chen4Xingqiang Lai5Maternal-Fetal Medicine Institute, Department of Obstetrics and Gynaecology, Shenzhen Baoan Women’s and Children’s Hospital, Shenzhen, ChinaMaternal-Fetal Medicine Institute, Department of Obstetrics and Gynaecology, Shenzhen Baoan Women’s and Children’s Hospital, Shenzhen, ChinaMaternal-Fetal Medicine Institute, Department of Obstetrics and Gynaecology, Shenzhen Baoan Women’s and Children’s Hospital, Shenzhen, ChinaMaternal-Fetal Medicine Institute, Department of Obstetrics and Gynaecology, Shenzhen Baoan Women’s and Children’s Hospital, Shenzhen, ChinaCorresponding authors.; Maternal-Fetal Medicine Institute, Department of Obstetrics and Gynaecology, Shenzhen Baoan Women’s and Children’s Hospital, Shenzhen, ChinaCorresponding authors.; Maternal-Fetal Medicine Institute, Department of Obstetrics and Gynaecology, Shenzhen Baoan Women’s and Children’s Hospital, Shenzhen, ChinaEdwards’ syndrome (trisomy 18) is a genetic disorder characterized by the presence of an extra chromosome 18. A specific induced pluripotent stem cell (iPSC) line, named BAFYi001-A, was generated from the umbilical cord-derived mesenchymal stromal cells (UC-MSCs) of a patient with Edwards syndrome using an integration-free Sendai virus method. This line expresses markers for identifying undifferentiated hiPSCs, trilineage differentiation potential, and genetic fidelity in the context of trisomy 18. Therefore, this cell line serves as a reliable in vitro model for investigating the pathogenesis of Edward syndrome.http://www.sciencedirect.com/science/article/pii/S1873506125000856 |
| spellingShingle | Qingqing Yang Simin Liu Jing Ruan Bo Sun Xiaoyan Chen Xingqiang Lai Establishment of human induced pluripotent stem cell line BAFYi001-A from a patient with Edwards syndrome Stem Cell Research |
| title | Establishment of human induced pluripotent stem cell line BAFYi001-A from a patient with Edwards syndrome |
| title_full | Establishment of human induced pluripotent stem cell line BAFYi001-A from a patient with Edwards syndrome |
| title_fullStr | Establishment of human induced pluripotent stem cell line BAFYi001-A from a patient with Edwards syndrome |
| title_full_unstemmed | Establishment of human induced pluripotent stem cell line BAFYi001-A from a patient with Edwards syndrome |
| title_short | Establishment of human induced pluripotent stem cell line BAFYi001-A from a patient with Edwards syndrome |
| title_sort | establishment of human induced pluripotent stem cell line bafyi001 a from a patient with edwards syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S1873506125000856 |
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