Dosimetry of automatic non-coplanar volumetric-modulated arc therapy for nasopharyngeal carcinoma
Objective: To evaluate the dosimetric quality of radiotherapy plans for nasopharyngeal carcinoma (NPC) using HyperArc (HA) technology. Methods: A retrospective analysis was conducted on 20 patients with initially diagnosed NPC who had received TomoTherapy (TOMO) treatment. Treatment plans were redes...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Radiation Medicine and Protection |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666555724001217 |
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| author | Kaiqiang Chen Jihong Chen Yanming Cheng Danni Hong Cairong Hu Penggang Bai Jinyong Lin Yang Yang Xiuchun Zhang |
| author_facet | Kaiqiang Chen Jihong Chen Yanming Cheng Danni Hong Cairong Hu Penggang Bai Jinyong Lin Yang Yang Xiuchun Zhang |
| author_sort | Kaiqiang Chen |
| collection | DOAJ |
| description | Objective: To evaluate the dosimetric quality of radiotherapy plans for nasopharyngeal carcinoma (NPC) using HyperArc (HA) technology. Methods: A retrospective analysis was conducted on 20 patients with initially diagnosed NPC who had received TomoTherapy (TOMO) treatment. Treatment plans were redesigned using HA technology on the Eclipse planning system. Dosimetric parameters and verification passing rates were collected to assess the dosimetric quality of target coverage and organ-at-risk (OAR) sparing in both sets of plans. Paired t-tests or Rank-Sum tests were used to compare the dosimetric parameters between the two plans. Results: For the planning target volumes (PTVs), the target coverage in both plans reached 95%. Compared with the TOMO plans, the HA plans exhibited a steeper dose fall-off for PTV69.75Gy (P < 0.05). However, the conformity index (CI) of the HA plans (0.75) was slightly lower than that of the TOMO plans (0.81, P < 0.05). The homogeneity index (HI) was better in the TOMO plans, with statistically significant differences for PTV69.75Gy and PTV55.80Gy (P < 0.05). Moreover, the HA plans had better sparing, particularly for the optic chiasm, optic nerves, and parotid glands (P < 0.05), while no statistically significant differences were observed for other critical structures such as the brainstem, spinal cord, and temporal lobes (P > 0.05). Additionally, the average beam-on time for the HA plans (252 s) was shorter than that of the TOMO plans (326 s, P < 0.05). The mean gamma passing rate at 3%/2 mm for all plans exceeded 98%. Conclusions: Radiotherapy plans for NPC based on HA technology exhibit excellent dosimetric quality, providing good target coverage, rapid dose fall-off, and effective protection of adjacent critical organs. |
| format | Article |
| id | doaj-art-d14c15142e774e948f2a36f27a48db47 |
| institution | Kabale University |
| issn | 2666-5557 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiation Medicine and Protection |
| spelling | doaj-art-d14c15142e774e948f2a36f27a48db472025-02-12T05:32:54ZengElsevierRadiation Medicine and Protection2666-55572025-02-01613742Dosimetry of automatic non-coplanar volumetric-modulated arc therapy for nasopharyngeal carcinomaKaiqiang Chen0Jihong Chen1Yanming Cheng2Danni Hong3Cairong Hu4Penggang Bai5Jinyong Lin6Yang Yang7Xiuchun Zhang8Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, ChinaDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, ChinaDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, ChinaDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, ChinaDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, ChinaDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, ChinaDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, ChinaCorresponding author.; Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, ChinaDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, ChinaObjective: To evaluate the dosimetric quality of radiotherapy plans for nasopharyngeal carcinoma (NPC) using HyperArc (HA) technology. Methods: A retrospective analysis was conducted on 20 patients with initially diagnosed NPC who had received TomoTherapy (TOMO) treatment. Treatment plans were redesigned using HA technology on the Eclipse planning system. Dosimetric parameters and verification passing rates were collected to assess the dosimetric quality of target coverage and organ-at-risk (OAR) sparing in both sets of plans. Paired t-tests or Rank-Sum tests were used to compare the dosimetric parameters between the two plans. Results: For the planning target volumes (PTVs), the target coverage in both plans reached 95%. Compared with the TOMO plans, the HA plans exhibited a steeper dose fall-off for PTV69.75Gy (P < 0.05). However, the conformity index (CI) of the HA plans (0.75) was slightly lower than that of the TOMO plans (0.81, P < 0.05). The homogeneity index (HI) was better in the TOMO plans, with statistically significant differences for PTV69.75Gy and PTV55.80Gy (P < 0.05). Moreover, the HA plans had better sparing, particularly for the optic chiasm, optic nerves, and parotid glands (P < 0.05), while no statistically significant differences were observed for other critical structures such as the brainstem, spinal cord, and temporal lobes (P > 0.05). Additionally, the average beam-on time for the HA plans (252 s) was shorter than that of the TOMO plans (326 s, P < 0.05). The mean gamma passing rate at 3%/2 mm for all plans exceeded 98%. Conclusions: Radiotherapy plans for NPC based on HA technology exhibit excellent dosimetric quality, providing good target coverage, rapid dose fall-off, and effective protection of adjacent critical organs.http://www.sciencedirect.com/science/article/pii/S2666555724001217Nasopharyngeal carcinomaHyperArcDosimetric comparison |
| spellingShingle | Kaiqiang Chen Jihong Chen Yanming Cheng Danni Hong Cairong Hu Penggang Bai Jinyong Lin Yang Yang Xiuchun Zhang Dosimetry of automatic non-coplanar volumetric-modulated arc therapy for nasopharyngeal carcinoma Radiation Medicine and Protection Nasopharyngeal carcinoma HyperArc Dosimetric comparison |
| title | Dosimetry of automatic non-coplanar volumetric-modulated arc therapy for nasopharyngeal carcinoma |
| title_full | Dosimetry of automatic non-coplanar volumetric-modulated arc therapy for nasopharyngeal carcinoma |
| title_fullStr | Dosimetry of automatic non-coplanar volumetric-modulated arc therapy for nasopharyngeal carcinoma |
| title_full_unstemmed | Dosimetry of automatic non-coplanar volumetric-modulated arc therapy for nasopharyngeal carcinoma |
| title_short | Dosimetry of automatic non-coplanar volumetric-modulated arc therapy for nasopharyngeal carcinoma |
| title_sort | dosimetry of automatic non coplanar volumetric modulated arc therapy for nasopharyngeal carcinoma |
| topic | Nasopharyngeal carcinoma HyperArc Dosimetric comparison |
| url | http://www.sciencedirect.com/science/article/pii/S2666555724001217 |
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