Similar Effects of General and Spinal Anaesthesia on Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy
Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-α: TNF-α), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were ass...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/97257 |
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| author | Unase Buyukkocak Osman Caglayan Cagatay Daphan Kuzey Aydinuraz Oral Saygun Tahsin Kaya Fatih Agalar |
| author_facet | Unase Buyukkocak Osman Caglayan Cagatay Daphan Kuzey Aydinuraz Oral Saygun Tahsin Kaya Fatih Agalar |
| author_sort | Unase Buyukkocak |
| collection | DOAJ |
| description | Surgery induces release of neuroendocrine hormones (cortisol),
cytokines (interleukin-6: IL-6, tumour necrosis factor-α: TNF-α), acute phase proteins (C-reactive protein: CRP,
leptin). We studied the effects of general and spinal anaesthesia
on stress response to haemorrhoidectomy. Patients were assigned to
general and spinal anaesthesia groups (n=7). Blood samples were
drawn before induction and 24 hours after surgery. Perioperative
levels of IL-6, TNF-α, CRP, cortisol, and leptin were
comparable among the groups. Twenty four hours after surgery,
TNF-α and cortisol did not change; IL-6 and CRP increased
significantly in all patients. Significant increase in leptin
levels was found in patients undergoing spinal anaesthesia. Except
for the increase in leptin levels, there was no significant
difference related to the effects of general and spinal
anaesthesia. |
| format | Article |
| id | doaj-art-d148e68ffe4a4dd1a5ce522c3ea63e0c |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d148e68ffe4a4dd1a5ce522c3ea63e0c2025-08-20T03:24:01ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/9725797257Similar Effects of General and Spinal Anaesthesia on Perioperative Stress Response in Patients Undergoing HaemorrhoidectomyUnase Buyukkocak0Osman Caglayan1Cagatay Daphan2Kuzey Aydinuraz3Oral Saygun4Tahsin Kaya5Fatih Agalar6Department of Anaesthesiology and Reanimation, School of Medicine, Kirikkale University, Kirikkale 71100, TurkeyDepartment of Biochemistry, School of Medicine, Kirikkale University, Kirikkale 71100, TurkeyDepartment of General Surgery, School of Medicine, Kirikkale University, Turkey 71100, TurkeyDepartment of General Surgery, School of Medicine, Kirikkale University, Turkey 71100, TurkeyDepartment of General Surgery, School of Medicine, Kirikkale University, Turkey 71100, TurkeyDepartment of Anaesthesiology and Reanimation, School of Medicine, Kirikkale University, Kirikkale 71100, TurkeyDepartment of General Surgery, School of Medicine, Kirikkale University, Turkey 71100, TurkeySurgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-α: TNF-α), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were assigned to general and spinal anaesthesia groups (n=7). Blood samples were drawn before induction and 24 hours after surgery. Perioperative levels of IL-6, TNF-α, CRP, cortisol, and leptin were comparable among the groups. Twenty four hours after surgery, TNF-α and cortisol did not change; IL-6 and CRP increased significantly in all patients. Significant increase in leptin levels was found in patients undergoing spinal anaesthesia. Except for the increase in leptin levels, there was no significant difference related to the effects of general and spinal anaesthesia.http://dx.doi.org/10.1155/MI/2006/97257 |
| spellingShingle | Unase Buyukkocak Osman Caglayan Cagatay Daphan Kuzey Aydinuraz Oral Saygun Tahsin Kaya Fatih Agalar Similar Effects of General and Spinal Anaesthesia on Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy Mediators of Inflammation |
| title | Similar Effects of General and Spinal Anaesthesia on
Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy |
| title_full | Similar Effects of General and Spinal Anaesthesia on
Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy |
| title_fullStr | Similar Effects of General and Spinal Anaesthesia on
Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy |
| title_full_unstemmed | Similar Effects of General and Spinal Anaesthesia on
Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy |
| title_short | Similar Effects of General and Spinal Anaesthesia on
Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy |
| title_sort | similar effects of general and spinal anaesthesia on perioperative stress response in patients undergoing haemorrhoidectomy |
| url | http://dx.doi.org/10.1155/MI/2006/97257 |
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