The prevalence and prognostic significance of Sarcopenia and Adipopenia in Pleural Mesothelioma
Introduction: Altered body composition is associated with adverse survival in multiple cancers. We determined the prevalence, prognostic significance and clinicopathological correlates of sarcopenia and adipopenia in Pleural Mesothelioma (PM) patients receiving chemotherapy. Methods: We performed a...
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Elsevier
2024-01-01
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| Series: | Cancer Treatment and Research Communications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468294224000686 |
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| author | Andrew C. Kidd Gordon W. Cowell Geoffrey A. Martin Jenny Ferguson Dean A. Fennell Matt Evison Kevin G. Blyth |
| author_facet | Andrew C. Kidd Gordon W. Cowell Geoffrey A. Martin Jenny Ferguson Dean A. Fennell Matt Evison Kevin G. Blyth |
| author_sort | Andrew C. Kidd |
| collection | DOAJ |
| description | Introduction: Altered body composition is associated with adverse survival in multiple cancers. We determined the prevalence, prognostic significance and clinicopathological correlates of sarcopenia and adipopenia in Pleural Mesothelioma (PM) patients receiving chemotherapy. Methods: We performed a multi-centre retrospective cohort study. Clinical data and CT images were retrieved for 111 patients from 4 UK centres. Skeletal muscle (at L3 and T4) and fat tissue areas (at L3 only) were measured on pre- and post-chemotherapy CT scans (ImageJ software) and normalised for height. Pre-chemotherapy sarcopenia and adipopenia were defined using validated thresholds, where available or indices <25th percentile. Muscle/fat loss were defined by < 0 % change (%∆) between CT scans. Extreme muscle/fat loss were defined by <25th percentile of %∆. Overall survival associations were evaluated using Kaplan–Meier methodology ± Cox proportional hazards models. Results: T4 and L3 measurements were possible in 111/111 and 91/111 (82 %). L3 sarcopenia was observed at baseline in 35 % (32/91); all other features were observed in 25 % at baseline, as defined a priori. Body composition changes during chemotherapy were heterogeneous. Overall, 61.5 % and 53.1 % patients lost muscle at L3 and T4. 60.4 % lost fat (at L3 only). Extreme T4 muscle loss and total fat loss were independently prognostic (HR 2.99, p < 0.001; HR 1.92, p = 0.014). Pre-chemotherapy T4 muscle indices were inversely associated with age. No associations were observed with tumour volume, histology, weight, inflammatory markers. Conclusion: T4 muscle indices were feasible in all cases and outperformed L3 values in prognostication. Extreme T4 muscle and total fat loss were independently prognostic. |
| format | Article |
| id | doaj-art-d147688208d4479fb31d9cc80d413e86 |
| institution | Kabale University |
| issn | 2468-2942 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Treatment and Research Communications |
| spelling | doaj-art-d147688208d4479fb31d9cc80d413e862025-02-09T05:00:45ZengElsevierCancer Treatment and Research Communications2468-29422024-01-0142100856The prevalence and prognostic significance of Sarcopenia and Adipopenia in Pleural MesotheliomaAndrew C. Kidd0Gordon W. Cowell1Geoffrey A. Martin2Jenny Ferguson3Dean A. Fennell4Matt Evison5Kevin G. Blyth6Glasgow Pleural Disease Unit, Queen Elizabeth University Hospital, Glasgow, UK; School of Cancer Sciences, University of Glasgow, UKSchool of Cancer Sciences, University of Glasgow, UK; Department of Radiology, Queen Elizabeth University Hospital, Glasgow, UKGlasgow Pleural Disease Unit, Queen Elizabeth University Hospital, Glasgow, UKGlasgow Pleural Disease Unit, Queen Elizabeth University Hospital, Glasgow, UKUniversity of Leicester, UKWythenshawe Hospital, Manchester, UK; Manchester Academic Health Science Centre (MAHSC), Faculty of Biology, Medicine & Health, University of Manchester, UKGlasgow Pleural Disease Unit, Queen Elizabeth University Hospital, Glasgow, UK; School of Cancer Sciences, University of Glasgow, UK; Corresponding author at: Professor of Respiratory Medicine and Honorary Consultant Respiratory Physician, School of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Switchback Rd, Glasgow, G61 1BD, UK.Introduction: Altered body composition is associated with adverse survival in multiple cancers. We determined the prevalence, prognostic significance and clinicopathological correlates of sarcopenia and adipopenia in Pleural Mesothelioma (PM) patients receiving chemotherapy. Methods: We performed a multi-centre retrospective cohort study. Clinical data and CT images were retrieved for 111 patients from 4 UK centres. Skeletal muscle (at L3 and T4) and fat tissue areas (at L3 only) were measured on pre- and post-chemotherapy CT scans (ImageJ software) and normalised for height. Pre-chemotherapy sarcopenia and adipopenia were defined using validated thresholds, where available or indices <25th percentile. Muscle/fat loss were defined by < 0 % change (%∆) between CT scans. Extreme muscle/fat loss were defined by <25th percentile of %∆. Overall survival associations were evaluated using Kaplan–Meier methodology ± Cox proportional hazards models. Results: T4 and L3 measurements were possible in 111/111 and 91/111 (82 %). L3 sarcopenia was observed at baseline in 35 % (32/91); all other features were observed in 25 % at baseline, as defined a priori. Body composition changes during chemotherapy were heterogeneous. Overall, 61.5 % and 53.1 % patients lost muscle at L3 and T4. 60.4 % lost fat (at L3 only). Extreme T4 muscle loss and total fat loss were independently prognostic (HR 2.99, p < 0.001; HR 1.92, p = 0.014). Pre-chemotherapy T4 muscle indices were inversely associated with age. No associations were observed with tumour volume, histology, weight, inflammatory markers. Conclusion: T4 muscle indices were feasible in all cases and outperformed L3 values in prognostication. Extreme T4 muscle and total fat loss were independently prognostic.http://www.sciencedirect.com/science/article/pii/S2468294224000686MesotheliomaCachexiaSarcopeniaAdipopeniaSurvival |
| spellingShingle | Andrew C. Kidd Gordon W. Cowell Geoffrey A. Martin Jenny Ferguson Dean A. Fennell Matt Evison Kevin G. Blyth The prevalence and prognostic significance of Sarcopenia and Adipopenia in Pleural Mesothelioma Cancer Treatment and Research Communications Mesothelioma Cachexia Sarcopenia Adipopenia Survival |
| title | The prevalence and prognostic significance of Sarcopenia and Adipopenia in Pleural Mesothelioma |
| title_full | The prevalence and prognostic significance of Sarcopenia and Adipopenia in Pleural Mesothelioma |
| title_fullStr | The prevalence and prognostic significance of Sarcopenia and Adipopenia in Pleural Mesothelioma |
| title_full_unstemmed | The prevalence and prognostic significance of Sarcopenia and Adipopenia in Pleural Mesothelioma |
| title_short | The prevalence and prognostic significance of Sarcopenia and Adipopenia in Pleural Mesothelioma |
| title_sort | prevalence and prognostic significance of sarcopenia and adipopenia in pleural mesothelioma |
| topic | Mesothelioma Cachexia Sarcopenia Adipopenia Survival |
| url | http://www.sciencedirect.com/science/article/pii/S2468294224000686 |
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