Circ_0000144 acts as a miR-1178-3p decoy to promote cell malignancy and angiogenesis by increasing YWHAH expression in papillary thyroid cancer
Highlights 1. Inhibition of circ_0000144 repressed malignant behaviors and angiogenesis of PTC cells in vitro. 2. Knockdown of circ_0000144 constrained PTC cell proliferation in vivo. 3. Circ_0000144 acted as a miR-1178-3p sponge. 4. YWHAH acted as a downstream target for miR-1178-3p.
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-07-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40463-022-00574-w |
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| _version_ | 1850283707380793344 |
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| author | Yinli Ma Dan Yang Pingan Guo |
| author_facet | Yinli Ma Dan Yang Pingan Guo |
| author_sort | Yinli Ma |
| collection | DOAJ |
| description | Highlights 1. Inhibition of circ_0000144 repressed malignant behaviors and angiogenesis of PTC cells in vitro. 2. Knockdown of circ_0000144 constrained PTC cell proliferation in vivo. 3. Circ_0000144 acted as a miR-1178-3p sponge. 4. YWHAH acted as a downstream target for miR-1178-3p. |
| format | Article |
| id | doaj-art-d1456b5d72c34879aea4e56ea7b896de |
| institution | OA Journals |
| issn | 1916-0216 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-d1456b5d72c34879aea4e56ea7b896de2025-08-20T01:47:44ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162022-07-0151111410.1186/s40463-022-00574-wCirc_0000144 acts as a miR-1178-3p decoy to promote cell malignancy and angiogenesis by increasing YWHAH expression in papillary thyroid cancerYinli Ma0Dan Yang1Pingan Guo2Department of Inspection, The First People’s Hospital of Fuyang DistrictDepartment of Inspection, The First People’s Hospital of Fuyang DistrictDepartment of Inspection, The First People’s Hospital of Fuyang DistrictHighlights 1. Inhibition of circ_0000144 repressed malignant behaviors and angiogenesis of PTC cells in vitro. 2. Knockdown of circ_0000144 constrained PTC cell proliferation in vivo. 3. Circ_0000144 acted as a miR-1178-3p sponge. 4. YWHAH acted as a downstream target for miR-1178-3p.https://doi.org/10.1186/s40463-022-00574-wPTCCirc_0,000,144miR-1178-3pYWHAHAngiogenesis |
| spellingShingle | Yinli Ma Dan Yang Pingan Guo Circ_0000144 acts as a miR-1178-3p decoy to promote cell malignancy and angiogenesis by increasing YWHAH expression in papillary thyroid cancer Journal of Otolaryngology - Head and Neck Surgery PTC Circ_0,000,144 miR-1178-3p YWHAH Angiogenesis |
| title | Circ_0000144 acts as a miR-1178-3p decoy to promote cell malignancy and angiogenesis by increasing YWHAH expression in papillary thyroid cancer |
| title_full | Circ_0000144 acts as a miR-1178-3p decoy to promote cell malignancy and angiogenesis by increasing YWHAH expression in papillary thyroid cancer |
| title_fullStr | Circ_0000144 acts as a miR-1178-3p decoy to promote cell malignancy and angiogenesis by increasing YWHAH expression in papillary thyroid cancer |
| title_full_unstemmed | Circ_0000144 acts as a miR-1178-3p decoy to promote cell malignancy and angiogenesis by increasing YWHAH expression in papillary thyroid cancer |
| title_short | Circ_0000144 acts as a miR-1178-3p decoy to promote cell malignancy and angiogenesis by increasing YWHAH expression in papillary thyroid cancer |
| title_sort | circ 0000144 acts as a mir 1178 3p decoy to promote cell malignancy and angiogenesis by increasing ywhah expression in papillary thyroid cancer |
| topic | PTC Circ_0,000,144 miR-1178-3p YWHAH Angiogenesis |
| url | https://doi.org/10.1186/s40463-022-00574-w |
| work_keys_str_mv | AT yinlima circ0000144actsasamir11783pdecoytopromotecellmalignancyandangiogenesisbyincreasingywhahexpressioninpapillarythyroidcancer AT danyang circ0000144actsasamir11783pdecoytopromotecellmalignancyandangiogenesisbyincreasingywhahexpressioninpapillarythyroidcancer AT pinganguo circ0000144actsasamir11783pdecoytopromotecellmalignancyandangiogenesisbyincreasingywhahexpressioninpapillarythyroidcancer |