Correlational study between SARS-CoV-2 infection and incidence of situs inversus in China
Abstract Wang and colleagues linked SARS-CoV-2 infection during early pregnancy to situs inversus, a rare developmental anomaly of organ placement. However, the absence of genetic testing data raises concerns regarding the reliability of their conclusions, particularly since a similar association wa...
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| Format: | Article |
| Language: | English |
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BMC
2025-08-01
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| Series: | Orphanet Journal of Rare Diseases |
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| Online Access: | https://doi.org/10.1186/s13023-025-03944-5 |
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| _version_ | 1849389082290946048 |
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| author | Zhenglong Guo Ruili Wang Wenke Yang Xin Chen Bingtao Hao Shixiu Liao |
| author_facet | Zhenglong Guo Ruili Wang Wenke Yang Xin Chen Bingtao Hao Shixiu Liao |
| author_sort | Zhenglong Guo |
| collection | DOAJ |
| description | Abstract Wang and colleagues linked SARS-CoV-2 infection during early pregnancy to situs inversus, a rare developmental anomaly of organ placement. However, the absence of genetic testing data raises concerns regarding the reliability of their conclusions, particularly since a similar association was not observed in Scandinavian countries. In this study, we summarize the cases of situs inversus diagnosed during the COVID-19 pandemic in Henan, China, which indicates a significant increase in the incidence of this condition. Among the 34 cases examined, 24 did not reveal any potential pathogenic variants through genetic testing. Our findings suggest a correlation between SARS-CoV-2 infection and the development of situs inversus. |
| format | Article |
| id | doaj-art-d145104f774e47bc9e96948efa30e210 |
| institution | Kabale University |
| issn | 1750-1172 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Orphanet Journal of Rare Diseases |
| spelling | doaj-art-d145104f774e47bc9e96948efa30e2102025-08-20T03:42:03ZengBMCOrphanet Journal of Rare Diseases1750-11722025-08-012011410.1186/s13023-025-03944-5Correlational study between SARS-CoV-2 infection and incidence of situs inversus in ChinaZhenglong Guo0Ruili Wang1Wenke Yang2Xin Chen3Bingtao Hao4Shixiu Liao5Henan Provincial Key Laboratory of Genetic Diseases and Functional Genomics, Medical Genetics Institute of Henan Province, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou UniversityHenan Provincial Key Laboratory of Genetic Diseases and Functional Genomics, Medical Genetics Institute of Henan Province, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou UniversityHenan Provincial Key Laboratory of Genetic Diseases and Functional Genomics, Medical Genetics Institute of Henan Province, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou UniversityHenan Provincial Key Laboratory of Genetic Diseases and Functional Genomics, Medical Genetics Institute of Henan Province, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou UniversityHenan Provincial Key Laboratory of Genetic Diseases and Functional Genomics, Medical Genetics Institute of Henan Province, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou UniversityHenan Provincial Key Laboratory of Genetic Diseases and Functional Genomics, Medical Genetics Institute of Henan Province, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou UniversityAbstract Wang and colleagues linked SARS-CoV-2 infection during early pregnancy to situs inversus, a rare developmental anomaly of organ placement. However, the absence of genetic testing data raises concerns regarding the reliability of their conclusions, particularly since a similar association was not observed in Scandinavian countries. In this study, we summarize the cases of situs inversus diagnosed during the COVID-19 pandemic in Henan, China, which indicates a significant increase in the incidence of this condition. Among the 34 cases examined, 24 did not reveal any potential pathogenic variants through genetic testing. Our findings suggest a correlation between SARS-CoV-2 infection and the development of situs inversus.https://doi.org/10.1186/s13023-025-03944-5SARS-CoV2Pregnancy outcomesSitus inversus |
| spellingShingle | Zhenglong Guo Ruili Wang Wenke Yang Xin Chen Bingtao Hao Shixiu Liao Correlational study between SARS-CoV-2 infection and incidence of situs inversus in China Orphanet Journal of Rare Diseases SARS-CoV2 Pregnancy outcomes Situs inversus |
| title | Correlational study between SARS-CoV-2 infection and incidence of situs inversus in China |
| title_full | Correlational study between SARS-CoV-2 infection and incidence of situs inversus in China |
| title_fullStr | Correlational study between SARS-CoV-2 infection and incidence of situs inversus in China |
| title_full_unstemmed | Correlational study between SARS-CoV-2 infection and incidence of situs inversus in China |
| title_short | Correlational study between SARS-CoV-2 infection and incidence of situs inversus in China |
| title_sort | correlational study between sars cov 2 infection and incidence of situs inversus in china |
| topic | SARS-CoV2 Pregnancy outcomes Situs inversus |
| url | https://doi.org/10.1186/s13023-025-03944-5 |
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