Correlational study between SARS-CoV-2 infection and incidence of situs inversus in China
Abstract Wang and colleagues linked SARS-CoV-2 infection during early pregnancy to situs inversus, a rare developmental anomaly of organ placement. However, the absence of genetic testing data raises concerns regarding the reliability of their conclusions, particularly since a similar association wa...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-08-01
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| Series: | Orphanet Journal of Rare Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13023-025-03944-5 |
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| Summary: | Abstract Wang and colleagues linked SARS-CoV-2 infection during early pregnancy to situs inversus, a rare developmental anomaly of organ placement. However, the absence of genetic testing data raises concerns regarding the reliability of their conclusions, particularly since a similar association was not observed in Scandinavian countries. In this study, we summarize the cases of situs inversus diagnosed during the COVID-19 pandemic in Henan, China, which indicates a significant increase in the incidence of this condition. Among the 34 cases examined, 24 did not reveal any potential pathogenic variants through genetic testing. Our findings suggest a correlation between SARS-CoV-2 infection and the development of situs inversus. |
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| ISSN: | 1750-1172 |