Hydrogel Contact Lens for Extended Delivery of Ophthalmic Drugs
Soft contact lenses can improve the bioavailability and prolong the residence time of drugs and, therefore, are ideal drug carriers for ophthalmic drug delivery. Hydrogels are the leading materials of soft contact lenses because of their biocompatibility and transparent characteristic. In order to i...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2011/814163 |
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| _version_ | 1849695872660537344 |
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| author | Xiaohong Hu Lingyun Hao Huaiqing Wang Xiaoli Yang Guojun Zhang Guoyu Wang Xiao Zhang |
| author_facet | Xiaohong Hu Lingyun Hao Huaiqing Wang Xiaoli Yang Guojun Zhang Guoyu Wang Xiao Zhang |
| author_sort | Xiaohong Hu |
| collection | DOAJ |
| description | Soft contact lenses can improve the bioavailability and prolong the residence time of drugs and, therefore, are ideal drug carriers for ophthalmic drug delivery. Hydrogels are the leading materials of soft contact lenses because of their biocompatibility and transparent characteristic. In order to increase the amount of load drug and to control their release at the expected intervals, many strategies are developed to modify the conventional contact lens as well as the novel hydrogel contact lenses that include (i) polymeric hydrogels with controlled hydrophilic/hydrophobic copolymer ratio; (ii) hydrogels for inclusion of drugs in a colloidal structure dispersed in the contact lenses; (iii) ligand-containing hydrogels; (iv) molecularly imprinted polymeric hydrogels; (v) hydrogel with the surface containing multilayer structure for drugs loading and releasing. The advantages and disadvantages of these strategies in modifying or designing hydrogel contact lenses for extended ophthalmic drug delivery are analyzed in this paper. |
| format | Article |
| id | doaj-art-d13ec3752f3c4e919e8da2821e372dbc |
| institution | DOAJ |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-d13ec3752f3c4e919e8da2821e372dbc2025-08-20T03:19:38ZengWileyInternational Journal of Polymer Science1687-94221687-94302011-01-01201110.1155/2011/814163814163Hydrogel Contact Lens for Extended Delivery of Ophthalmic DrugsXiaohong Hu0Lingyun Hao1Huaiqing Wang2Xiaoli Yang3Guojun Zhang4Guoyu Wang5Xiao Zhang6School of Material Engineering, Jinling Institute of Technology, Nanjing 211169, ChinaSchool of Material Engineering, Jinling Institute of Technology, Nanjing 211169, ChinaSchool of Material Engineering, Jinling Institute of Technology, Nanjing 211169, ChinaSchool of Material Engineering, Jinling Institute of Technology, Nanjing 211169, ChinaSchool of Material Engineering, Jinling Institute of Technology, Nanjing 211169, ChinaSchool of Material Engineering, Jinling Institute of Technology, Nanjing 211169, ChinaSchool of Material Engineering, Jinling Institute of Technology, Nanjing 211169, ChinaSoft contact lenses can improve the bioavailability and prolong the residence time of drugs and, therefore, are ideal drug carriers for ophthalmic drug delivery. Hydrogels are the leading materials of soft contact lenses because of their biocompatibility and transparent characteristic. In order to increase the amount of load drug and to control their release at the expected intervals, many strategies are developed to modify the conventional contact lens as well as the novel hydrogel contact lenses that include (i) polymeric hydrogels with controlled hydrophilic/hydrophobic copolymer ratio; (ii) hydrogels for inclusion of drugs in a colloidal structure dispersed in the contact lenses; (iii) ligand-containing hydrogels; (iv) molecularly imprinted polymeric hydrogels; (v) hydrogel with the surface containing multilayer structure for drugs loading and releasing. The advantages and disadvantages of these strategies in modifying or designing hydrogel contact lenses for extended ophthalmic drug delivery are analyzed in this paper.http://dx.doi.org/10.1155/2011/814163 |
| spellingShingle | Xiaohong Hu Lingyun Hao Huaiqing Wang Xiaoli Yang Guojun Zhang Guoyu Wang Xiao Zhang Hydrogel Contact Lens for Extended Delivery of Ophthalmic Drugs International Journal of Polymer Science |
| title | Hydrogel Contact Lens for Extended Delivery of Ophthalmic Drugs |
| title_full | Hydrogel Contact Lens for Extended Delivery of Ophthalmic Drugs |
| title_fullStr | Hydrogel Contact Lens for Extended Delivery of Ophthalmic Drugs |
| title_full_unstemmed | Hydrogel Contact Lens for Extended Delivery of Ophthalmic Drugs |
| title_short | Hydrogel Contact Lens for Extended Delivery of Ophthalmic Drugs |
| title_sort | hydrogel contact lens for extended delivery of ophthalmic drugs |
| url | http://dx.doi.org/10.1155/2011/814163 |
| work_keys_str_mv | AT xiaohonghu hydrogelcontactlensforextendeddeliveryofophthalmicdrugs AT lingyunhao hydrogelcontactlensforextendeddeliveryofophthalmicdrugs AT huaiqingwang hydrogelcontactlensforextendeddeliveryofophthalmicdrugs AT xiaoliyang hydrogelcontactlensforextendeddeliveryofophthalmicdrugs AT guojunzhang hydrogelcontactlensforextendeddeliveryofophthalmicdrugs AT guoyuwang hydrogelcontactlensforextendeddeliveryofophthalmicdrugs AT xiaozhang hydrogelcontactlensforextendeddeliveryofophthalmicdrugs |