Clinical Features and Treatment Responses of Children With Eosinophilic Gastroenteritis
Clinical features and treatment responses in pediatric patients with eosinophilic gastroenteritis are rarely reported. This study aimed to evaluate the clinical manifestations and outcome of eosinophilic gastroenteritis in children of Asian background. Methods: Between 1997 and 2009, 14 Taiwanese pa...
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| Format: | Article |
| Language: | English |
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Elsevier
2011-10-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957211000969 |
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| author | Fu-Mien Tien Jia-Feng Wu Yung-Ming Jeng Hong-Yuan Hsu Yen-Hsuan Ni Mei-Hwei Chang Dong-Tsamn Lin Huey-Ling Chen |
| author_facet | Fu-Mien Tien Jia-Feng Wu Yung-Ming Jeng Hong-Yuan Hsu Yen-Hsuan Ni Mei-Hwei Chang Dong-Tsamn Lin Huey-Ling Chen |
| author_sort | Fu-Mien Tien |
| collection | DOAJ |
| description | Clinical features and treatment responses in pediatric patients with eosinophilic gastroenteritis are rarely reported. This study aimed to evaluate the clinical manifestations and outcome of eosinophilic gastroenteritis in children of Asian background.
Methods: Between 1997 and 2009, 14 Taiwanese patients (nine boys and five girls), with median age of 8.3 years (range, 1.4–14.3 years), were diagnosed with eosinophilic gastroenteritis. The diagnosis was confirmed by the presence of gastrointestinal symptoms, peripheral eosinophilia, and a histology-proved biopsy. The clinical data and responses to medical treatment were analyzed.
Results: Initial symptoms included abdominal pain (43%), anemia (36%), hypoalbuminemia (14%), recurrent vomiting (7%), bloody stool (7%), and growth failure (7%). Peripheral eosinophilia was present in 10 patients (71.4%) and positive stool occult blood in seven patients (50%). Endoscopic examination revealed ulcer disease in four patients (28.6%). The treatment included steroid alone, montelukast alone, steroid+montelukast, and steroid+montelukast+ketotifen. Among the patients treated with steroid, two (two of nine, 22%) had successfully tapered off steroid without recurring symptoms. Three patients (three of nine, 33%) had relapses after discontinuing steroid, three (three of nine, 33%) still required low-dose steroid, and one lost to follow-up. There was no relapse in the four patients treated with montelukast alone.
Conclusions: A high percentage of patients presented with gross or occult gastrointestinal bleeding with or without abdominal pain. Endoscopic biopsy is necessary for diagnosis. Steroid was the mainstay treatment for active diseases; montelukast was also effective for the disease or as a maintenance therapy in this study. |
| format | Article |
| id | doaj-art-d13e68cf408b4dcdab62da5ba1366a18 |
| institution | OA Journals |
| issn | 1875-9572 |
| language | English |
| publishDate | 2011-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-d13e68cf408b4dcdab62da5ba1366a182025-08-20T02:19:55ZengElsevierPediatrics and Neonatology1875-95722011-10-0152527227810.1016/j.pedneo.2011.06.006Clinical Features and Treatment Responses of Children With Eosinophilic GastroenteritisFu-Mien Tien0Jia-Feng Wu1Yung-Ming Jeng2Hong-Yuan Hsu3Yen-Hsuan Ni4Mei-Hwei Chang5Dong-Tsamn Lin6Huey-Ling Chen7Department of Pediatrics, National Taiwan University Children’s Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Children’s Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Children’s Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Children’s Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Children’s Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Children’s Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Children’s Hospital and National Taiwan University College of Medicine, Taipei, TaiwanClinical features and treatment responses in pediatric patients with eosinophilic gastroenteritis are rarely reported. This study aimed to evaluate the clinical manifestations and outcome of eosinophilic gastroenteritis in children of Asian background. Methods: Between 1997 and 2009, 14 Taiwanese patients (nine boys and five girls), with median age of 8.3 years (range, 1.4–14.3 years), were diagnosed with eosinophilic gastroenteritis. The diagnosis was confirmed by the presence of gastrointestinal symptoms, peripheral eosinophilia, and a histology-proved biopsy. The clinical data and responses to medical treatment were analyzed. Results: Initial symptoms included abdominal pain (43%), anemia (36%), hypoalbuminemia (14%), recurrent vomiting (7%), bloody stool (7%), and growth failure (7%). Peripheral eosinophilia was present in 10 patients (71.4%) and positive stool occult blood in seven patients (50%). Endoscopic examination revealed ulcer disease in four patients (28.6%). The treatment included steroid alone, montelukast alone, steroid+montelukast, and steroid+montelukast+ketotifen. Among the patients treated with steroid, two (two of nine, 22%) had successfully tapered off steroid without recurring symptoms. Three patients (three of nine, 33%) had relapses after discontinuing steroid, three (three of nine, 33%) still required low-dose steroid, and one lost to follow-up. There was no relapse in the four patients treated with montelukast alone. Conclusions: A high percentage of patients presented with gross or occult gastrointestinal bleeding with or without abdominal pain. Endoscopic biopsy is necessary for diagnosis. Steroid was the mainstay treatment for active diseases; montelukast was also effective for the disease or as a maintenance therapy in this study.http://www.sciencedirect.com/science/article/pii/S1875957211000969childreneosinophiliaeosinophilic gastroenteritisgastrointestinal bleeding |
| spellingShingle | Fu-Mien Tien Jia-Feng Wu Yung-Ming Jeng Hong-Yuan Hsu Yen-Hsuan Ni Mei-Hwei Chang Dong-Tsamn Lin Huey-Ling Chen Clinical Features and Treatment Responses of Children With Eosinophilic Gastroenteritis Pediatrics and Neonatology children eosinophilia eosinophilic gastroenteritis gastrointestinal bleeding |
| title | Clinical Features and Treatment Responses of Children With Eosinophilic Gastroenteritis |
| title_full | Clinical Features and Treatment Responses of Children With Eosinophilic Gastroenteritis |
| title_fullStr | Clinical Features and Treatment Responses of Children With Eosinophilic Gastroenteritis |
| title_full_unstemmed | Clinical Features and Treatment Responses of Children With Eosinophilic Gastroenteritis |
| title_short | Clinical Features and Treatment Responses of Children With Eosinophilic Gastroenteritis |
| title_sort | clinical features and treatment responses of children with eosinophilic gastroenteritis |
| topic | children eosinophilia eosinophilic gastroenteritis gastrointestinal bleeding |
| url | http://www.sciencedirect.com/science/article/pii/S1875957211000969 |
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