The molecular mechanisms of IUGR programmed adulthood cardiovascular disease
Intrauterine growth restriction (IUGR) is secondary to several maternal and fetal adverse conditions. Recently, there is a convincing association between the onset of IUGR and adulthood programmed complications. Among them, the disorders in the cardiovascular system have been revealed by a series of...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1589038/full |
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| author | Ting Wu Ting Wu Wen Zhang Wen Zhang Yangong Wang Hong Luo Hong Luo Yifei Li Yifei Li Yifei Li |
| author_facet | Ting Wu Ting Wu Wen Zhang Wen Zhang Yangong Wang Hong Luo Hong Luo Yifei Li Yifei Li Yifei Li |
| author_sort | Ting Wu |
| collection | DOAJ |
| description | Intrauterine growth restriction (IUGR) is secondary to several maternal and fetal adverse conditions. Recently, there is a convincing association between the onset of IUGR and adulthood programmed complications. Among them, the disorders in the cardiovascular system have been revealed by a series of researches. Currently, the prevalence of IUGR is considered to be related to programmed hypertension, coronary artery lesions, pulmonary hypertension, metabolic dysfunction, and even heart failure. According to the emerging knowledge in this field, the experiences of IUGR would induce prolonged inflammation, oxidative injuries, aberrant metabolites and epigenetic regulation, which resulted in endothelial, smooth muscle cells and cardiomyocytes damages. In this review, we summarized the evidences and progress in establishing the association between IUGR and programmed cardiovascular diseases and involved molecular mechanisms. Furthermore, we also discussed the potential efficient therapeutic strategies. This comprehensive review demonstrated that IUGR manifested long-term consequences persisting into adulthood through multifaceted molecular pathways, notably oxidative stress mechanisms, mitochondrial dysfunction, and epigenetic alterations. These findings underscored the critical importance of implementing early preventive interventions and developing personalized therapeutic approaches in future clinical practice. |
| format | Article |
| id | doaj-art-d13d4824444a4683a5bcb94d5fe5fef3 |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-d13d4824444a4683a5bcb94d5fe5fef32025-08-20T03:10:06ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-05-011310.3389/fcell.2025.15890381589038The molecular mechanisms of IUGR programmed adulthood cardiovascular diseaseTing Wu0Ting Wu1Wen Zhang2Wen Zhang3Yangong Wang4Hong Luo5Hong Luo6Yifei Li7Yifei Li8Yifei Li9Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Ultrasonic Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Ultrasonic Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaMinhang Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Ultrasonic Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaMinhang Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaIntrauterine growth restriction (IUGR) is secondary to several maternal and fetal adverse conditions. Recently, there is a convincing association between the onset of IUGR and adulthood programmed complications. Among them, the disorders in the cardiovascular system have been revealed by a series of researches. Currently, the prevalence of IUGR is considered to be related to programmed hypertension, coronary artery lesions, pulmonary hypertension, metabolic dysfunction, and even heart failure. According to the emerging knowledge in this field, the experiences of IUGR would induce prolonged inflammation, oxidative injuries, aberrant metabolites and epigenetic regulation, which resulted in endothelial, smooth muscle cells and cardiomyocytes damages. In this review, we summarized the evidences and progress in establishing the association between IUGR and programmed cardiovascular diseases and involved molecular mechanisms. Furthermore, we also discussed the potential efficient therapeutic strategies. This comprehensive review demonstrated that IUGR manifested long-term consequences persisting into adulthood through multifaceted molecular pathways, notably oxidative stress mechanisms, mitochondrial dysfunction, and epigenetic alterations. These findings underscored the critical importance of implementing early preventive interventions and developing personalized therapeutic approaches in future clinical practice.https://www.frontiersin.org/articles/10.3389/fcell.2025.1589038/fullIUGRcardiovascular diseaseprogrammed diseasesmolecular mechanismsepigenetic modificationtherapy |
| spellingShingle | Ting Wu Ting Wu Wen Zhang Wen Zhang Yangong Wang Hong Luo Hong Luo Yifei Li Yifei Li Yifei Li The molecular mechanisms of IUGR programmed adulthood cardiovascular disease Frontiers in Cell and Developmental Biology IUGR cardiovascular disease programmed diseases molecular mechanisms epigenetic modification therapy |
| title | The molecular mechanisms of IUGR programmed adulthood cardiovascular disease |
| title_full | The molecular mechanisms of IUGR programmed adulthood cardiovascular disease |
| title_fullStr | The molecular mechanisms of IUGR programmed adulthood cardiovascular disease |
| title_full_unstemmed | The molecular mechanisms of IUGR programmed adulthood cardiovascular disease |
| title_short | The molecular mechanisms of IUGR programmed adulthood cardiovascular disease |
| title_sort | molecular mechanisms of iugr programmed adulthood cardiovascular disease |
| topic | IUGR cardiovascular disease programmed diseases molecular mechanisms epigenetic modification therapy |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1589038/full |
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