A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research
Abstract With an evolving understanding and new discoveries in extracellular vesicle (EV) biology and their implications in health and disease, the significant diagnostic and therapeutic potential of EVs for vision research has gained recognition. In 2021, the National Eye Institute (NEI) unveiled i...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Journal of Extracellular Vesicles |
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| Online Access: | https://doi.org/10.1002/jev2.70023 |
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| author | Sun Young Lee Mikael Klingeborn Jeff W. M. Bulte Daniel T. Chiu Michael Chopp Christopher W. Cutler Saumya Das Charles E. Egwuagu Christie D. Fowler Sarah F. Hamm‐Alvarez Hakho Lee Yutao Liu Ben Mead Tara L. Moore Sriram Ravindran Ashok K. Shetty Johan Skog Kenneth W. Witwer Ali R. Djalilian Alissa M. Weaver |
| author_facet | Sun Young Lee Mikael Klingeborn Jeff W. M. Bulte Daniel T. Chiu Michael Chopp Christopher W. Cutler Saumya Das Charles E. Egwuagu Christie D. Fowler Sarah F. Hamm‐Alvarez Hakho Lee Yutao Liu Ben Mead Tara L. Moore Sriram Ravindran Ashok K. Shetty Johan Skog Kenneth W. Witwer Ali R. Djalilian Alissa M. Weaver |
| author_sort | Sun Young Lee |
| collection | DOAJ |
| description | Abstract With an evolving understanding and new discoveries in extracellular vesicle (EV) biology and their implications in health and disease, the significant diagnostic and therapeutic potential of EVs for vision research has gained recognition. In 2021, the National Eye Institute (NEI) unveiled its Strategic Plan titled ‘Vision for the Future (2021–2025),’ which listed EV research as a priority within the domain of Regenerative Medicine, a pivotal area outlined in the Plan. In alignment with this prioritization, NEI organized a workshop inviting twenty experts from within and beyond the visual system. The workshop aimed to review current knowledge in EV research and explore gaps, needs and opportunities for EV research in the eye, including EV biology and applications of EVs in diagnosis, therapy and prognosis within the visual system. This perspective encapsulates the workshop's deliberations, highlighting the current landscape and potential implications of EV research in advancing eye health and addressing visual diseases. |
| format | Article |
| id | doaj-art-d13b142aee074760ae2c52f6346384c1 |
| institution | Kabale University |
| issn | 2001-3078 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Extracellular Vesicles |
| spelling | doaj-art-d13b142aee074760ae2c52f6346384c12025-01-17T11:11:12ZengWileyJournal of Extracellular Vesicles2001-30782024-12-011312n/an/a10.1002/jev2.70023A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision researchSun Young Lee0Mikael Klingeborn1Jeff W. M. Bulte2Daniel T. Chiu3Michael Chopp4Christopher W. Cutler5Saumya Das6Charles E. Egwuagu7Christie D. Fowler8Sarah F. Hamm‐Alvarez9Hakho Lee10Yutao Liu11Ben Mead12Tara L. Moore13Sriram Ravindran14Ashok K. Shetty15Johan Skog16Kenneth W. Witwer17Ali R. Djalilian18Alissa M. Weaver19Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine University of Southern California Los Angeles California USAMcLaughlin Research Institute Great Falls Montana USADepartment of Radiology and Radiological Sciences, School of Medicine Johns Hopkins University Baltimore Maryland USADepartment of Chemistry and Bioengineering University of Washington Seattle Washington USADepartment of Neurology Henry Ford Health Detroit Michigan USADepartment of Periodontics Dental College of Georgia at Augusta University Georgia USACardiovascular Research Center Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USAMolecular Immunology Section, Laboratory of Immunology, National Eye Institute National Institutes of Health Bethesda Maryland USADepartment of Neurobiology and Behavior University of California Irvine Irvine California USADepartment of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine University of Southern California Los Angeles California USACenter for System Biology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USADepartment of Cellular Biology and Anatomy, Medical College of Georgia Augusta University Augusta Georgia USASchool of Optometry and Vision Sciences Cardiff University Cardiff UKDepartment of Anatomy and Neurobiology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USADepartment of Oral Biology, College of Dentistry University of Illinois Chicago Chicago Illinois USAInstitute for Regenerative Medicine, Department of Cell Biology and Genetics Texas A&M University School of Medicine College Station Texas USAExosome Diagnostics, a Bio‐Techne Brand Waltham Massachusetts USADepartment of Molecular and Comparative Pathobiology Johns Hopkins University School of Medicine Baltimore Maryland USADepartment of Ophthalmology and Visual Sciences University of Illinois at Chicago Chicago Illinois USADepartment of Cell and Developmental Biology Vanderbilt University School of Medicine Nashville Tennessee USAAbstract With an evolving understanding and new discoveries in extracellular vesicle (EV) biology and their implications in health and disease, the significant diagnostic and therapeutic potential of EVs for vision research has gained recognition. In 2021, the National Eye Institute (NEI) unveiled its Strategic Plan titled ‘Vision for the Future (2021–2025),’ which listed EV research as a priority within the domain of Regenerative Medicine, a pivotal area outlined in the Plan. In alignment with this prioritization, NEI organized a workshop inviting twenty experts from within and beyond the visual system. The workshop aimed to review current knowledge in EV research and explore gaps, needs and opportunities for EV research in the eye, including EV biology and applications of EVs in diagnosis, therapy and prognosis within the visual system. This perspective encapsulates the workshop's deliberations, highlighting the current landscape and potential implications of EV research in advancing eye health and addressing visual diseases.https://doi.org/10.1002/jev2.70023EyeEVsexosomesdiagnosisocularprognosis |
| spellingShingle | Sun Young Lee Mikael Klingeborn Jeff W. M. Bulte Daniel T. Chiu Michael Chopp Christopher W. Cutler Saumya Das Charles E. Egwuagu Christie D. Fowler Sarah F. Hamm‐Alvarez Hakho Lee Yutao Liu Ben Mead Tara L. Moore Sriram Ravindran Ashok K. Shetty Johan Skog Kenneth W. Witwer Ali R. Djalilian Alissa M. Weaver A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research Journal of Extracellular Vesicles Eye EVs exosomes diagnosis ocular prognosis |
| title | A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research |
| title_full | A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research |
| title_fullStr | A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research |
| title_full_unstemmed | A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research |
| title_short | A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research |
| title_sort | perspective from the national eye institute extracellular vesicle workshop gaps needs and opportunities for studies of extracellular vesicles in vision research |
| topic | Eye EVs exosomes diagnosis ocular prognosis |
| url | https://doi.org/10.1002/jev2.70023 |
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