Significantly improving the solubility and anti-inflammatory activity of fenofibric acid with native and methyl-substituted beta-cyclodextrins via complexation
Abstract The solubility of commonly used anti-inflammatory drugs has become a significant concern in contemporary medicine. Furthermore, inflammatory arthritis stands out as the most prevalent chronic inflammatory disease globally. The disease’s pathology is characterized by heightened inflammation...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-84745-x |
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| author | Rajaram Rajamohan Perumal Muthuraja Kuppusamy Murugavel Murali Krishnan Mani D. S. Prabakaran Jeong Hyun Seo Tabarak Malik Yong Rok Lee |
| author_facet | Rajaram Rajamohan Perumal Muthuraja Kuppusamy Murugavel Murali Krishnan Mani D. S. Prabakaran Jeong Hyun Seo Tabarak Malik Yong Rok Lee |
| author_sort | Rajaram Rajamohan |
| collection | DOAJ |
| description | Abstract The solubility of commonly used anti-inflammatory drugs has become a significant concern in contemporary medicine. Furthermore, inflammatory arthritis stands out as the most prevalent chronic inflammatory disease globally. The disease’s pathology is characterized by heightened inflammation and oxidative stress, culminating in chronic pain and the loss of joint functionality. Fenofibric acid (FFA) exhibits notable anti-inflammatory potential. This research assesses the anti-inflammatory effects of FFA, both in its standalone form and as inclusion complexes (ICs) with β-cyclodextrin and its methyl derivatives. FFA is encapsulated within the cavities of cyclodextrins (CDs), a fact confirmed by spectral changes observed in FFA. Distinct rock and seed-like morphologies are apparent for FFA with CDs, indicating that the CDs have influenced the surface of the guest. The introduction of CDs significantly enhances the thermal stability of FFA. ICs demonstrate superior results in inflammation activity compared to FFA alone. The efficacy of FFA complexed with CDs in mitigating inflammation positions it as a promising new drug. Additionally, our findings reveal that incorporating FFA into the CD cavity as a drug release system enhances the pharmacological profile of this substance, FFA. |
| format | Article |
| id | doaj-art-d13a43a203de439c809cce08e13467ac |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-d13a43a203de439c809cce08e13467ac2025-01-05T12:22:36ZengNature PortfolioScientific Reports2045-23222025-01-0115111710.1038/s41598-024-84745-xSignificantly improving the solubility and anti-inflammatory activity of fenofibric acid with native and methyl-substituted beta-cyclodextrins via complexationRajaram Rajamohan0Perumal Muthuraja1Kuppusamy Murugavel2Murali Krishnan Mani3D. S. Prabakaran4Jeong Hyun Seo5Tabarak Malik6Yong Rok Lee7School of Chemical Engineering, Yeungnam UniversitySchool of Chemical Engineering, Yeungnam UniversityPG & Research Department of Chemistry, Government Arts CollegeDepartment of Chemistry, Bannari Amman Institute of TechnologyDepartment of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, KattankulathurSchool of Chemical Engineering, Yeungnam UniversityDepartment of Biomedical Sciences, Institute of Health, Jimma UniversitySchool of Chemical Engineering, Yeungnam UniversityAbstract The solubility of commonly used anti-inflammatory drugs has become a significant concern in contemporary medicine. Furthermore, inflammatory arthritis stands out as the most prevalent chronic inflammatory disease globally. The disease’s pathology is characterized by heightened inflammation and oxidative stress, culminating in chronic pain and the loss of joint functionality. Fenofibric acid (FFA) exhibits notable anti-inflammatory potential. This research assesses the anti-inflammatory effects of FFA, both in its standalone form and as inclusion complexes (ICs) with β-cyclodextrin and its methyl derivatives. FFA is encapsulated within the cavities of cyclodextrins (CDs), a fact confirmed by spectral changes observed in FFA. Distinct rock and seed-like morphologies are apparent for FFA with CDs, indicating that the CDs have influenced the surface of the guest. The introduction of CDs significantly enhances the thermal stability of FFA. ICs demonstrate superior results in inflammation activity compared to FFA alone. The efficacy of FFA complexed with CDs in mitigating inflammation positions it as a promising new drug. Additionally, our findings reveal that incorporating FFA into the CD cavity as a drug release system enhances the pharmacological profile of this substance, FFA.https://doi.org/10.1038/s41598-024-84745-xFenofibric acidBeta-cyclodextrinsComplexationROESY analysisAnti-inflammationMTT assay |
| spellingShingle | Rajaram Rajamohan Perumal Muthuraja Kuppusamy Murugavel Murali Krishnan Mani D. S. Prabakaran Jeong Hyun Seo Tabarak Malik Yong Rok Lee Significantly improving the solubility and anti-inflammatory activity of fenofibric acid with native and methyl-substituted beta-cyclodextrins via complexation Scientific Reports Fenofibric acid Beta-cyclodextrins Complexation ROESY analysis Anti-inflammation MTT assay |
| title | Significantly improving the solubility and anti-inflammatory activity of fenofibric acid with native and methyl-substituted beta-cyclodextrins via complexation |
| title_full | Significantly improving the solubility and anti-inflammatory activity of fenofibric acid with native and methyl-substituted beta-cyclodextrins via complexation |
| title_fullStr | Significantly improving the solubility and anti-inflammatory activity of fenofibric acid with native and methyl-substituted beta-cyclodextrins via complexation |
| title_full_unstemmed | Significantly improving the solubility and anti-inflammatory activity of fenofibric acid with native and methyl-substituted beta-cyclodextrins via complexation |
| title_short | Significantly improving the solubility and anti-inflammatory activity of fenofibric acid with native and methyl-substituted beta-cyclodextrins via complexation |
| title_sort | significantly improving the solubility and anti inflammatory activity of fenofibric acid with native and methyl substituted beta cyclodextrins via complexation |
| topic | Fenofibric acid Beta-cyclodextrins Complexation ROESY analysis Anti-inflammation MTT assay |
| url | https://doi.org/10.1038/s41598-024-84745-x |
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