Asymptomatic Primary Hyperparathyroidism: A Misnomer
Abstract Primary hyperparathyroidism (PHPT) is an endocrine disorder marked by elevated secretion of parathyroid hormone (PTH), which results in hypercalcemia and may cause complications in the kidneys and bones. Diagnosing this condition involves ruling out secondary causes and understanding the co...
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| Format: | Article |
| Language: | English |
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Wiley
2024-10-01
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| Series: | OTO Open |
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| Online Access: | https://doi.org/10.1002/oto2.70039 |
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| author | Hänel W. Eberly Bao Y. Sciscent F. Jeffrey Lorenz Neerav Goyal David Goldenberg |
| author_facet | Hänel W. Eberly Bao Y. Sciscent F. Jeffrey Lorenz Neerav Goyal David Goldenberg |
| author_sort | Hänel W. Eberly |
| collection | DOAJ |
| description | Abstract Primary hyperparathyroidism (PHPT) is an endocrine disorder marked by elevated secretion of parathyroid hormone (PTH), which results in hypercalcemia and may cause complications in the kidneys and bones. Diagnosing this condition involves ruling out secondary causes and understanding the complexities of the laboratory values associated with PHPT. The disease has become more recognizable to clinicians in an earlier phase thanks to updated screening guidelines. At present, patients can be diagnosed with “classic,” “normocalcemic,” “normohormonal,” or “asymptomatic” PHPT. Many patients are diagnosed through incidental findings of elevated calcium levels or PTH levels during routine blood tests rather than through the presentation of classic symptoms. If asked, patients will invariably harbor subtle or subclinical manifestations despite the absence of overt symptoms. There is debate on whether truly asymptomatic hyperparathyroidism exists.1 We explore the definition and clinical patterns of asymptomatic hyperparathyroidism and propose concise recommendations for recognizing these patients. |
| format | Article |
| id | doaj-art-d1365025742f414bab3ac9db9b306208 |
| institution | DOAJ |
| issn | 2473-974X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | OTO Open |
| spelling | doaj-art-d1365025742f414bab3ac9db9b3062082025-08-20T02:53:22ZengWileyOTO Open2473-974X2024-10-0184n/an/a10.1002/oto2.70039Asymptomatic Primary Hyperparathyroidism: A MisnomerHänel W. Eberly0Bao Y. Sciscent1F. Jeffrey Lorenz2Neerav Goyal3David Goldenberg4Department of Otolaryngology–Head and Neck Surgery Penn State College of Medicine and Penn State Milton S. Hershey Medical Center Hershey Pennsylvania USADepartment of Otolaryngology–Head and Neck Surgery Penn State College of Medicine and Penn State Milton S. Hershey Medical Center Hershey Pennsylvania USADepartment of Otolaryngology–Head and Neck Surgery Penn State College of Medicine and Penn State Milton S. Hershey Medical Center Hershey Pennsylvania USADepartment of Otolaryngology–Head and Neck Surgery Penn State College of Medicine and Penn State Milton S. Hershey Medical Center Hershey Pennsylvania USADepartment of Otolaryngology–Head and Neck Surgery Penn State College of Medicine and Penn State Milton S. Hershey Medical Center Hershey Pennsylvania USAAbstract Primary hyperparathyroidism (PHPT) is an endocrine disorder marked by elevated secretion of parathyroid hormone (PTH), which results in hypercalcemia and may cause complications in the kidneys and bones. Diagnosing this condition involves ruling out secondary causes and understanding the complexities of the laboratory values associated with PHPT. The disease has become more recognizable to clinicians in an earlier phase thanks to updated screening guidelines. At present, patients can be diagnosed with “classic,” “normocalcemic,” “normohormonal,” or “asymptomatic” PHPT. Many patients are diagnosed through incidental findings of elevated calcium levels or PTH levels during routine blood tests rather than through the presentation of classic symptoms. If asked, patients will invariably harbor subtle or subclinical manifestations despite the absence of overt symptoms. There is debate on whether truly asymptomatic hyperparathyroidism exists.1 We explore the definition and clinical patterns of asymptomatic hyperparathyroidism and propose concise recommendations for recognizing these patients.https://doi.org/10.1002/oto2.70039asymptomatic hyperparathyroidismhyperparathyroidismparathyroidectomy |
| spellingShingle | Hänel W. Eberly Bao Y. Sciscent F. Jeffrey Lorenz Neerav Goyal David Goldenberg Asymptomatic Primary Hyperparathyroidism: A Misnomer OTO Open asymptomatic hyperparathyroidism hyperparathyroidism parathyroidectomy |
| title | Asymptomatic Primary Hyperparathyroidism: A Misnomer |
| title_full | Asymptomatic Primary Hyperparathyroidism: A Misnomer |
| title_fullStr | Asymptomatic Primary Hyperparathyroidism: A Misnomer |
| title_full_unstemmed | Asymptomatic Primary Hyperparathyroidism: A Misnomer |
| title_short | Asymptomatic Primary Hyperparathyroidism: A Misnomer |
| title_sort | asymptomatic primary hyperparathyroidism a misnomer |
| topic | asymptomatic hyperparathyroidism hyperparathyroidism parathyroidectomy |
| url | https://doi.org/10.1002/oto2.70039 |
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