Mammalian tRNA acetylation determines translation efficiency and tRNA quality control

Mammalian tRNA acetylation determines translation efficiency and tRNA quality control

Abstract Acetylation is a conserved and pivotal RNA modification. Acetylation of tRNA occurs at C12 (ac4C12) in eukaryotic tRNAs. Yeast ac4C12 prevents tRNASer from rapid tRNA decay (RTD) at higher temperatures. However, the biological function of ac4C12 in higher eukaryotes remains unexplored. More...

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Main Authors: Na Liu, Bingxue Liu, Chun-Rui Ma, Zixin Cai, Jin-Tao Wang, Zi-Qing Chai, Nanlin Zhu, Ting Shao, Yue-Lei Chen, Yu Lin, Yirong Wang, Hong Xu, Xiao-Long Zhou
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60723-3
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