Hymecromone Efficacy in the Treatment of Biliary Pancreatitis
Aim. To study the contribution of biliary sludge (BS) to the development of chronic pancreatitis in patients with gallbladder sludge and verified chronic pancreatitis; to evaluate the clinical efficacy and safety of hymecromone therapy according to clinical and laboratory signs, as well as dynamics...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2019-12-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/418 |
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| author | A. V. Okhlobystin M. A. Tatarkina O. Z. Okhlobystina S. A. Budzinskiy P. V. Pavlov L. A. Labut |
| author_facet | A. V. Okhlobystin M. A. Tatarkina O. Z. Okhlobystina S. A. Budzinskiy P. V. Pavlov L. A. Labut |
| author_sort | A. V. Okhlobystin |
| collection | DOAJ |
| description | Aim. To study the contribution of biliary sludge (BS) to the development of chronic pancreatitis in patients with gallbladder sludge and verified chronic pancreatitis; to evaluate the clinical efficacy and safety of hymecromone therapy according to clinical and laboratory signs, as well as dynamics of gallbladder size and contractility.Materials and methods. An open single-centre clinical trial included 30 patients with chronic pancreatitis (CP), which was diagnosed according to the Cambridge criteria. All patients received hymocromone (Odeston®) 400 mg tid for 3 weeks. An analysis of the efficacy and safety of the studied drug was performed on the 21st day of treatment based on the results of laboratory tests, abdominal ultrasound, cholecystography and endosonography of the pancreatobiliary zone, quality-of-life assessment according to the SF-36 questionnaire, the frequency and severity of adverse effects (AE).Results. CP signs were found in 6.3 % of patients with gallbladder BS. CP was significantly more frequent in patients with putty-like bile (33.3 %, χ2 = 38.21, p < 0.00001). The area of the major duodenal papilla (MDP) was below normal in 78% of patients. According to factor analysis, monotherapy with hymocromone resulted in a decrease in abdominal pain, nausea, heaviness in the abdomen and bloating. By the end of the therapy, the quality of life according to the “BP” bodily pain scale of the SF-36 questionnaire significantly increased.Conclusions. Biliary sludge (including undiagnosed forms during routine examination) was found to be a factor in the development of CP. The medical correction of biliary disorders in CP should include selective antispasmodics. Hymecromone therapy demonstrates a good level of tolerability and safety, normalizes the motor function of the biliary tract and sphincter tone over a short period of time, and relieves CP symptoms. |
| format | Article |
| id | doaj-art-d131db32b5de4256ab6cce350b960984 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2019-12-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-d131db32b5de4256ab6cce350b9609842025-02-10T16:14:35ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732019-12-01295263510.22416/1382-4376-2019-29-5-26-35326Hymecromone Efficacy in the Treatment of Biliary PancreatitisA. V. Okhlobystin0M. A. Tatarkina1O. Z. Okhlobystina2S. A. Budzinskiy3P. V. Pavlov4L. A. Labut5I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)The Russian National Research Medical University named after N.I. PirogovI.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)Aim. To study the contribution of biliary sludge (BS) to the development of chronic pancreatitis in patients with gallbladder sludge and verified chronic pancreatitis; to evaluate the clinical efficacy and safety of hymecromone therapy according to clinical and laboratory signs, as well as dynamics of gallbladder size and contractility.Materials and methods. An open single-centre clinical trial included 30 patients with chronic pancreatitis (CP), which was diagnosed according to the Cambridge criteria. All patients received hymocromone (Odeston®) 400 mg tid for 3 weeks. An analysis of the efficacy and safety of the studied drug was performed on the 21st day of treatment based on the results of laboratory tests, abdominal ultrasound, cholecystography and endosonography of the pancreatobiliary zone, quality-of-life assessment according to the SF-36 questionnaire, the frequency and severity of adverse effects (AE).Results. CP signs were found in 6.3 % of patients with gallbladder BS. CP was significantly more frequent in patients with putty-like bile (33.3 %, χ2 = 38.21, p < 0.00001). The area of the major duodenal papilla (MDP) was below normal in 78% of patients. According to factor analysis, monotherapy with hymocromone resulted in a decrease in abdominal pain, nausea, heaviness in the abdomen and bloating. By the end of the therapy, the quality of life according to the “BP” bodily pain scale of the SF-36 questionnaire significantly increased.Conclusions. Biliary sludge (including undiagnosed forms during routine examination) was found to be a factor in the development of CP. The medical correction of biliary disorders in CP should include selective antispasmodics. Hymecromone therapy demonstrates a good level of tolerability and safety, normalizes the motor function of the biliary tract and sphincter tone over a short period of time, and relieves CP symptoms.https://www.gastro-j.ru/jour/article/view/418biliary pancreatitisbiliary sludgehymocromonetransabdominal ultrasound |
| spellingShingle | A. V. Okhlobystin M. A. Tatarkina O. Z. Okhlobystina S. A. Budzinskiy P. V. Pavlov L. A. Labut Hymecromone Efficacy in the Treatment of Biliary Pancreatitis Российский журнал гастроэнтерологии, гепатологии, колопроктологии biliary pancreatitis biliary sludge hymocromone transabdominal ultrasound |
| title | Hymecromone Efficacy in the Treatment of Biliary Pancreatitis |
| title_full | Hymecromone Efficacy in the Treatment of Biliary Pancreatitis |
| title_fullStr | Hymecromone Efficacy in the Treatment of Biliary Pancreatitis |
| title_full_unstemmed | Hymecromone Efficacy in the Treatment of Biliary Pancreatitis |
| title_short | Hymecromone Efficacy in the Treatment of Biliary Pancreatitis |
| title_sort | hymecromone efficacy in the treatment of biliary pancreatitis |
| topic | biliary pancreatitis biliary sludge hymocromone transabdominal ultrasound |
| url | https://www.gastro-j.ru/jour/article/view/418 |
| work_keys_str_mv | AT avokhlobystin hymecromoneefficacyinthetreatmentofbiliarypancreatitis AT matatarkina hymecromoneefficacyinthetreatmentofbiliarypancreatitis AT ozokhlobystina hymecromoneefficacyinthetreatmentofbiliarypancreatitis AT sabudzinskiy hymecromoneefficacyinthetreatmentofbiliarypancreatitis AT pvpavlov hymecromoneefficacyinthetreatmentofbiliarypancreatitis AT lalabut hymecromoneefficacyinthetreatmentofbiliarypancreatitis |