Ursolic acid drug-drug nanocrystals ameliorate cholestatic liver injury via inhibiting oxidative stress and regulating bile acid metabolism

Ursolic acid drug-drug nanocrystals ameliorate cholestatic liver injury via inhibiting oxidative stress and regulating bile acid metabolism

IntroductionCholestatic liver injury (CLI) is a liver dysfunction closely associated with oxidative stress and bile acid (BA) metabolic disorders, but effective therapies are lacking.The use of ursolic acid (UA) and α-Tocopherol succinate (VES) together for treating CLI is promising due to their res...

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Bibliographic Details
Main Authors: Manhang Hu, Xiaolu Hua, Wei Xiong, Enhui Zheng, Xingyue Yang, Yu Lu, Bing He, Xiaolin Zhong, Zongzhe Jiang, Qingbi Zhang, Yan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
ursolic acid
nanocrystals
cholestatic liver injury
VES
oxidative stress
PXR/CYP3A4/UGT1A1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1586141/full
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