Neonatal 5,7-DHT Lesions Cause Sex-Specific Changes in Mouse Cortical Morphogenesis
Both monoaminergic and cholinergic afferent projections to the neocortex putatively modulate cortical morphogenesis and plasticity. Previously we showed that neonatal,electrolytic lesions: the cholinergic nucleus basalis magnocel!ularis (nBM) projections to the neocortex result in significant decrea...
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| Format: | Article |
| Language: | English |
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Wiley
2000-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2000.213 |
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| author | Christine F. Hohmann Celena Richardson Ella Pitts Joanne Berger-Sweeney |
| author_facet | Christine F. Hohmann Celena Richardson Ella Pitts Joanne Berger-Sweeney |
| author_sort | Christine F. Hohmann |
| collection | DOAJ |
| description | Both monoaminergic and cholinergic afferent
projections to the neocortex putatively modulate
cortical morphogenesis and plasticity. Previously
we showed that neonatal,electrolytic lesions:
the cholinergic nucleus basalis magnocel!ularis
(nBM) projections to the neocortex result in
significant decreases-of cortical layer width that
correlate with cognitive alterations. Such electrolytic
lesions, performed for lack of a selective
neurotoxin in mice, may affect mono- aminergic
fibers of passage. Here, we investigate the effects
of neonatal 5,7 dihydroxytryptamine (5,7-DHT)
focal injections into the nBM region on cortical
laminar morphology in adult male and female
mice. 5,7-DHT lesions on the first postnatal day
resulted in significant cortical depletion of both
serotonin and norepinephrine that attenuated
with age. Generally, cortical layer widths
increased in response to the lesion; the effects
were layer, region, and sex specific. Previous
reports from our laboratories described longterm
behavioral alterations after comparable
focal, neonatal 5,7-DHT lesions. The studies
described here provide an anatomical basis for
such behavioral alterations. Our data suggest
that monoaminergic and cholinergic projections to the cortex may have opposite effects on the
developing cortical neuropil. Jointly, our
morphological and behavioral findings may
have important implications for a variety of
developmental disorders in humans and
provide some insights into sex differences in the
penetrance of these disorders. |
| format | Article |
| id | doaj-art-d13085842fa24811876b7cc24f29be18 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-d13085842fa24811876b7cc24f29be182025-02-03T01:30:11ZengWileyNeural Plasticity2090-59041687-54432000-01-017421323210.1155/NP.2000.213Neonatal 5,7-DHT Lesions Cause Sex-Specific Changes in Mouse Cortical MorphogenesisChristine F. Hohmann0Celena Richardson1Ella Pitts2Joanne Berger-Sweeney3Morgan State University, Baltimore, MD, USAMorgan State University, Baltimore, MD, USAMorgan State University, Baltimore, MD, USAWellesley College, Wellesley, MA, USABoth monoaminergic and cholinergic afferent projections to the neocortex putatively modulate cortical morphogenesis and plasticity. Previously we showed that neonatal,electrolytic lesions: the cholinergic nucleus basalis magnocel!ularis (nBM) projections to the neocortex result in significant decreases-of cortical layer width that correlate with cognitive alterations. Such electrolytic lesions, performed for lack of a selective neurotoxin in mice, may affect mono- aminergic fibers of passage. Here, we investigate the effects of neonatal 5,7 dihydroxytryptamine (5,7-DHT) focal injections into the nBM region on cortical laminar morphology in adult male and female mice. 5,7-DHT lesions on the first postnatal day resulted in significant cortical depletion of both serotonin and norepinephrine that attenuated with age. Generally, cortical layer widths increased in response to the lesion; the effects were layer, region, and sex specific. Previous reports from our laboratories described longterm behavioral alterations after comparable focal, neonatal 5,7-DHT lesions. The studies described here provide an anatomical basis for such behavioral alterations. Our data suggest that monoaminergic and cholinergic projections to the cortex may have opposite effects on the developing cortical neuropil. Jointly, our morphological and behavioral findings may have important implications for a variety of developmental disorders in humans and provide some insights into sex differences in the penetrance of these disorders.http://dx.doi.org/10.1155/NP.2000.213 |
| spellingShingle | Christine F. Hohmann Celena Richardson Ella Pitts Joanne Berger-Sweeney Neonatal 5,7-DHT Lesions Cause Sex-Specific Changes in Mouse Cortical Morphogenesis Neural Plasticity |
| title | Neonatal 5,7-DHT Lesions Cause Sex-Specific Changes in Mouse Cortical Morphogenesis |
| title_full | Neonatal 5,7-DHT Lesions Cause Sex-Specific Changes in Mouse Cortical Morphogenesis |
| title_fullStr | Neonatal 5,7-DHT Lesions Cause Sex-Specific Changes in Mouse Cortical Morphogenesis |
| title_full_unstemmed | Neonatal 5,7-DHT Lesions Cause Sex-Specific Changes in Mouse Cortical Morphogenesis |
| title_short | Neonatal 5,7-DHT Lesions Cause Sex-Specific Changes in Mouse Cortical Morphogenesis |
| title_sort | neonatal 5 7 dht lesions cause sex specific changes in mouse cortical morphogenesis |
| url | http://dx.doi.org/10.1155/NP.2000.213 |
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