Study of efficacy and safety of pharmacological stress tests in nuclear cardiology
Background/Aim. Treadmill test combined with myocardial perfusion scintigraphy (MPS) is a commonly used technique in the assessment of coronary artery disease. Many patients who cannot adequately perform exercise stress testing may nevertheless undergo pharmacological tests, most commonly with the v...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2009-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2009/0042-84500903193B.pdf |
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| author | Baškot Branislav Rafajlovski Sašo Ristić-Angelkov Anđelka Obradović Slobodan Gligić Branko Orozović Vjekoslav Agbaba Nikola |
| author_facet | Baškot Branislav Rafajlovski Sašo Ristić-Angelkov Anđelka Obradović Slobodan Gligić Branko Orozović Vjekoslav Agbaba Nikola |
| author_sort | Baškot Branislav |
| collection | DOAJ |
| description | Background/Aim. Treadmill test combined with myocardial perfusion scintigraphy (MPS) is a commonly used technique in the assessment of coronary artery disease. Many patients who cannot adequately perform exercise stress testing may nevertheless undergo pharmacological tests, most commonly with the vasodilator agents (adenosine and dipyridamole), as well as the positive inotropic agent dobutamine. Patients undergoing vasodilators stress testing with either dipyridamole or adenosine also perform simultaneous low-intensity exercise. The aim of this study was to compare various pharmacological stress tests alone or in combination with low intensity exercise as preparation for MPS in reagard to incidence of adverse effects, quality of diagnostic image and the acquisition initial time. Methods. A total of 2 205 patients underwent pharmacological stress tests. Pharmacological stress test with adenosine was applied in 493 patients. In 405 of them we performed concomitant low level exercise (50 W) by bicycle ergometar (AdenoEX). In 88 of them we performed adenosine abbreviated protocol (AdenoSCAN). In 1 526 patients we performed pharmacological stress test with dipyridamole. In 871 of them we performed concomitant low level exercise (50 W) by bicycle ergometar (DipyEX), and in 775 we used only dipyridamole protocol (DipySCAN). In 186 patients we used pharmacological stress test with dobutamine. We followed side effects of adenosine, dipyiridamole and dobutamine, compared results between protocols with concomitant low level exercise and vasodilatators only. We also compared image quality, and suggested time of acquisition after stress test. Results. We found numerous side effects especially with adenosine, but these effects were short-lived and not required active interventions. Benefit with concomitant exercise in booth AdenoEX and DipyEX included decreased side effects (AdenoEX vs AdenoSCAN 62% vs 87%, respectively, and DipyEX vs DipySCAN 37% vs 59%, respectively) improved safety and patients tolerance, improved target-to-background ratios because of less subdiaphragmal activity, and earlier acquisition time. Because of producing a lot of arrhythmias (in 49% of patients) dobutamin was considered a last choice for pharmacological stress testing. Conclusion. Safety and efficacy of vasodilatators (adenosine, dipyridamole) pharmacological stress tests are good, but with concomitant exercise even better. The safety and efficacy of adenosin are better than those of dipyridamole. AdenoEX protocol provides good safety and patients tolerance. In light of these benefits we recommend AdenoEX whenever possible. Dobutamine is the last pharmacological toll for MPS. |
| format | Article |
| id | doaj-art-d12df66ecd5b47e8b4865f9392e6c6db |
| institution | OA Journals |
| issn | 0042-8450 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
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| series | Vojnosanitetski Pregled |
| spelling | doaj-art-d12df66ecd5b47e8b4865f9392e6c6db2025-08-20T02:19:55ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502009-01-0166319319810.2298/VSP0903193BStudy of efficacy and safety of pharmacological stress tests in nuclear cardiologyBaškot BranislavRafajlovski SašoRistić-Angelkov AnđelkaObradović SlobodanGligić BrankoOrozović VjekoslavAgbaba NikolaBackground/Aim. Treadmill test combined with myocardial perfusion scintigraphy (MPS) is a commonly used technique in the assessment of coronary artery disease. Many patients who cannot adequately perform exercise stress testing may nevertheless undergo pharmacological tests, most commonly with the vasodilator agents (adenosine and dipyridamole), as well as the positive inotropic agent dobutamine. Patients undergoing vasodilators stress testing with either dipyridamole or adenosine also perform simultaneous low-intensity exercise. The aim of this study was to compare various pharmacological stress tests alone or in combination with low intensity exercise as preparation for MPS in reagard to incidence of adverse effects, quality of diagnostic image and the acquisition initial time. Methods. A total of 2 205 patients underwent pharmacological stress tests. Pharmacological stress test with adenosine was applied in 493 patients. In 405 of them we performed concomitant low level exercise (50 W) by bicycle ergometar (AdenoEX). In 88 of them we performed adenosine abbreviated protocol (AdenoSCAN). In 1 526 patients we performed pharmacological stress test with dipyridamole. In 871 of them we performed concomitant low level exercise (50 W) by bicycle ergometar (DipyEX), and in 775 we used only dipyridamole protocol (DipySCAN). In 186 patients we used pharmacological stress test with dobutamine. We followed side effects of adenosine, dipyiridamole and dobutamine, compared results between protocols with concomitant low level exercise and vasodilatators only. We also compared image quality, and suggested time of acquisition after stress test. Results. We found numerous side effects especially with adenosine, but these effects were short-lived and not required active interventions. Benefit with concomitant exercise in booth AdenoEX and DipyEX included decreased side effects (AdenoEX vs AdenoSCAN 62% vs 87%, respectively, and DipyEX vs DipySCAN 37% vs 59%, respectively) improved safety and patients tolerance, improved target-to-background ratios because of less subdiaphragmal activity, and earlier acquisition time. Because of producing a lot of arrhythmias (in 49% of patients) dobutamin was considered a last choice for pharmacological stress testing. Conclusion. Safety and efficacy of vasodilatators (adenosine, dipyridamole) pharmacological stress tests are good, but with concomitant exercise even better. The safety and efficacy of adenosin are better than those of dipyridamole. AdenoEX protocol provides good safety and patients tolerance. In light of these benefits we recommend AdenoEX whenever possible. Dobutamine is the last pharmacological toll for MPS.http://www.doiserbia.nb.rs/img/doi/0042-8450/2009/0042-84500903193B.pdfcoronary diseaseradionuclide imagingergometryadenosinedipyridamoledobutamine |
| spellingShingle | Baškot Branislav Rafajlovski Sašo Ristić-Angelkov Anđelka Obradović Slobodan Gligić Branko Orozović Vjekoslav Agbaba Nikola Study of efficacy and safety of pharmacological stress tests in nuclear cardiology Vojnosanitetski Pregled coronary disease radionuclide imaging ergometry adenosine dipyridamole dobutamine |
| title | Study of efficacy and safety of pharmacological stress tests in nuclear cardiology |
| title_full | Study of efficacy and safety of pharmacological stress tests in nuclear cardiology |
| title_fullStr | Study of efficacy and safety of pharmacological stress tests in nuclear cardiology |
| title_full_unstemmed | Study of efficacy and safety of pharmacological stress tests in nuclear cardiology |
| title_short | Study of efficacy and safety of pharmacological stress tests in nuclear cardiology |
| title_sort | study of efficacy and safety of pharmacological stress tests in nuclear cardiology |
| topic | coronary disease radionuclide imaging ergometry adenosine dipyridamole dobutamine |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2009/0042-84500903193B.pdf |
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