Examination of the relationship between serum zinc levels and peripheral neuropathy induced by paclitaxel/carboplatin combination therapy in gynecological cancer patients
Objectives: Chemotherapy-induced peripheral neuropathy (CIPN), a frequently occurring adverse event associated with paclitaxel/carboplatin (TC) combination therapy, causes limb pain and markedly reduces the patient’s quality of life. Since zinc has been reported to be associated with neuropathic p...
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Fujita Medical Society
2025-02-01
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| Series: | Fujita Medical Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/fmj/11/1/11_2024-013/_pdf/-char/ja |
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| author | Yutaka Torii Kana Naito Junichi Takagi Akira Yasue Kazuhiko Tsukada Takuma Fujii Haruki Nishizawa |
| author_facet | Yutaka Torii Kana Naito Junichi Takagi Akira Yasue Kazuhiko Tsukada Takuma Fujii Haruki Nishizawa |
| author_sort | Yutaka Torii |
| collection | DOAJ |
| description | Objectives: Chemotherapy-induced peripheral neuropathy (CIPN), a frequently occurring adverse event associated
with paclitaxel/carboplatin (TC) combination therapy, causes limb pain and markedly reduces the patient’s quality of
life. Since zinc has been reported to be associated with neuropathic pain, we investigated the relationship between
CIPN due to TC therapy and serum zinc levels.
Methods: The study included 13 patients with gynecological cancer whose serum zinc levels were measured before
and during TC therapy. CIPN was classified into severity grades based on the Common Terminology Criteria for
Adverse Events v5.0. A retrospective analysis was conducted on the relationship between the serum zinc level
before TC therapy (PreZn), the minimum serum zinc level measured during TC therapy (MinZn), the MinZn/PreZn
ratio, the number of TC treatment cycles, and the maximum grade of CIPN (MaxG) using Pearson’s correlation
coefficient. Moreover, an analysis was also conducted on clinical factors influencing MaxG, as well as fluctuations in
serum zinc levels and CIPN grades for each cycle of TC therapy.
Results: A negative correlation was observed between the MinZn/PreZn ratio and MaxG (r=–0.557, p=0.048). The
clinical factors influencing CIPN remained unclear, and the decrease in serum zinc levels and the aggravation of
CIPN plateaued after the third cycle.
Conclusions: If a decrease in serum zinc levels during TC therapy is smaller than before therapy, it may imply the
existence of a causal relationship that suppresses the aggravation of CIPN. |
| format | Article |
| id | doaj-art-d12d837415ed4623b2ee8df75164c056 |
| institution | Kabale University |
| issn | 2189-7247 2189-7255 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Fujita Medical Society |
| record_format | Article |
| series | Fujita Medical Journal |
| spelling | doaj-art-d12d837415ed4623b2ee8df75164c0562025-02-04T05:25:23ZengFujita Medical SocietyFujita Medical Journal2189-72472189-72552025-02-01111111910.20407/fmj.2024-013Examination of the relationship between serum zinc levels and peripheral neuropathy induced by paclitaxel/carboplatin combination therapy in gynecological cancer patientsYutaka Torii0Kana Naito1Junichi Takagi2Akira Yasue3Kazuhiko Tsukada4Takuma Fujii5Haruki Nishizawa6Department of Obstetrics and Gynecology, Fujita Health University, School of Medicine; Department of Gynecology, Fujita Health University Okazaki Medical CenterDepartment of Obstetrics and Gynecology, Fujita Health University, School of MedicineDepartment of Obstetrics and Gynecology, Fujita Health University, School of Medicine; Department of Gynecology, Fujita Health University Okazaki Medical CenterDepartment of Gynecology, Fujita Health University Okazaki Medical CenterDepartment of Gynecology, Fujita Health University Okazaki Medical CenterDepartment of Gynecology, Fujita Health University Okazaki Medical CenterDepartment of Obstetrics and Gynecology, Fujita Health University, School of MedicineObjectives: Chemotherapy-induced peripheral neuropathy (CIPN), a frequently occurring adverse event associated with paclitaxel/carboplatin (TC) combination therapy, causes limb pain and markedly reduces the patient’s quality of life. Since zinc has been reported to be associated with neuropathic pain, we investigated the relationship between CIPN due to TC therapy and serum zinc levels. Methods: The study included 13 patients with gynecological cancer whose serum zinc levels were measured before and during TC therapy. CIPN was classified into severity grades based on the Common Terminology Criteria for Adverse Events v5.0. A retrospective analysis was conducted on the relationship between the serum zinc level before TC therapy (PreZn), the minimum serum zinc level measured during TC therapy (MinZn), the MinZn/PreZn ratio, the number of TC treatment cycles, and the maximum grade of CIPN (MaxG) using Pearson’s correlation coefficient. Moreover, an analysis was also conducted on clinical factors influencing MaxG, as well as fluctuations in serum zinc levels and CIPN grades for each cycle of TC therapy. Results: A negative correlation was observed between the MinZn/PreZn ratio and MaxG (r=–0.557, p=0.048). The clinical factors influencing CIPN remained unclear, and the decrease in serum zinc levels and the aggravation of CIPN plateaued after the third cycle. Conclusions: If a decrease in serum zinc levels during TC therapy is smaller than before therapy, it may imply the existence of a causal relationship that suppresses the aggravation of CIPN.https://www.jstage.jst.go.jp/article/fmj/11/1/11_2024-013/_pdf/-char/jachemotherapy-induced peripheral neuropathyzinctc therapy |
| spellingShingle | Yutaka Torii Kana Naito Junichi Takagi Akira Yasue Kazuhiko Tsukada Takuma Fujii Haruki Nishizawa Examination of the relationship between serum zinc levels and peripheral neuropathy induced by paclitaxel/carboplatin combination therapy in gynecological cancer patients Fujita Medical Journal chemotherapy-induced peripheral neuropathy zinc tc therapy |
| title | Examination of the relationship between serum zinc levels and peripheral neuropathy induced by paclitaxel/carboplatin combination therapy in gynecological cancer patients |
| title_full | Examination of the relationship between serum zinc levels and peripheral neuropathy induced by paclitaxel/carboplatin combination therapy in gynecological cancer patients |
| title_fullStr | Examination of the relationship between serum zinc levels and peripheral neuropathy induced by paclitaxel/carboplatin combination therapy in gynecological cancer patients |
| title_full_unstemmed | Examination of the relationship between serum zinc levels and peripheral neuropathy induced by paclitaxel/carboplatin combination therapy in gynecological cancer patients |
| title_short | Examination of the relationship between serum zinc levels and peripheral neuropathy induced by paclitaxel/carboplatin combination therapy in gynecological cancer patients |
| title_sort | examination of the relationship between serum zinc levels and peripheral neuropathy induced by paclitaxel carboplatin combination therapy in gynecological cancer patients |
| topic | chemotherapy-induced peripheral neuropathy zinc tc therapy |
| url | https://www.jstage.jst.go.jp/article/fmj/11/1/11_2024-013/_pdf/-char/ja |
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