BDNF Val66Met polymorphism moderates associations between physical activity and neurocognitive outcomes in older adults

BDNF Val66Met polymorphism moderates associations between physical activity and neurocognitive outcomes in older adults

Abstract INTRODUCTION Increased brain‐derived neurotrophic factor (BDNF) release through physical activity (PA) is thought to underlie protective effects of PA on brain aging. The BDNF Val66Met single‐nucleotide polymorphism (rs6265) reduces activity‐dependent BDNF release and has been linked to ear...

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Bibliographic Details
Main Authors: Claire J. Cadwallader, Anna M. VandeBunte, D. Luke Fischer, Coty Chen, Valentina E. Diaz, Shannon Y. Lee, Brandon Chan, Argentina Lario‐Lago, Julio C. Rojas, Eliana Marisa Ramos, Jessica E. Rexach, Jennifer S. Yokoyama, Joel H. Kramer, Emily W. Paolillo, Rowan Saloner, Kaitlin B. Casaletto
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
Alzheimer's disease
BDNF Val66Met single‐nucleotide polymorphism
cognition
healthy aging
GFAP
physical activity
Online Access:https://doi.org/10.1002/trc2.70106
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