Hidden allies: how extracellular vesicles drive biofilm formation, stress adaptation, and host–immune interactions in human fungal pathogens
ABSTRACT Pathogenic fungi pose a significant threat to human health, especially given the rising incidence of invasive fungal infections and the emergence of drug-resistant strains. This requires the development of vaccines and the advancement of antifungal strategies. Recent studies have focused on...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2024-12-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mbio.03045-23 |
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| author | Philipp Brandt Rima Singha Iuliana V. Ene |
| author_facet | Philipp Brandt Rima Singha Iuliana V. Ene |
| author_sort | Philipp Brandt |
| collection | DOAJ |
| description | ABSTRACT Pathogenic fungi pose a significant threat to human health, especially given the rising incidence of invasive fungal infections and the emergence of drug-resistant strains. This requires the development of vaccines and the advancement of antifungal strategies. Recent studies have focused on the roles of fungal extracellular vesicles (EVs) in intercellular communication and host-pathogen interactions. EVs are nanosized, lipid membrane-bound particles that facilitate the transfer of proteins, lipids, and nucleic acids. Here, we review the multifaceted functions of EVs produced by different human fungal pathogens, highlighting their importance in the response of fungal cells to different environmental cues and their interactions with host immune cells. We summarize the current state of research on EVs and how leveraging this knowledge can lead to innovative approaches in vaccine development and antifungal treatment. |
| format | Article |
| id | doaj-art-d12b13612a0b410dbd80d197ea035d5e |
| institution | OA Journals |
| issn | 2150-7511 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj-art-d12b13612a0b410dbd80d197ea035d5e2025-08-20T01:58:59ZengAmerican Society for MicrobiologymBio2150-75112024-12-01151210.1128/mbio.03045-23Hidden allies: how extracellular vesicles drive biofilm formation, stress adaptation, and host–immune interactions in human fungal pathogensPhilipp Brandt0Rima Singha1Iuliana V. Ene2Institut Pasteur, Université Paris Cité, Fungal Heterogeneity Group, Paris, FranceInstitut Pasteur, Université Paris Cité, Fungal Heterogeneity Group, Paris, FranceInstitut Pasteur, Université Paris Cité, Fungal Heterogeneity Group, Paris, FranceABSTRACT Pathogenic fungi pose a significant threat to human health, especially given the rising incidence of invasive fungal infections and the emergence of drug-resistant strains. This requires the development of vaccines and the advancement of antifungal strategies. Recent studies have focused on the roles of fungal extracellular vesicles (EVs) in intercellular communication and host-pathogen interactions. EVs are nanosized, lipid membrane-bound particles that facilitate the transfer of proteins, lipids, and nucleic acids. Here, we review the multifaceted functions of EVs produced by different human fungal pathogens, highlighting their importance in the response of fungal cells to different environmental cues and their interactions with host immune cells. We summarize the current state of research on EVs and how leveraging this knowledge can lead to innovative approaches in vaccine development and antifungal treatment.https://journals.asm.org/doi/10.1128/mbio.03045-23extracellular vesiclesfungal pathogensbiofilmsdrug resistanceimmunitystress response |
| spellingShingle | Philipp Brandt Rima Singha Iuliana V. Ene Hidden allies: how extracellular vesicles drive biofilm formation, stress adaptation, and host–immune interactions in human fungal pathogens mBio extracellular vesicles fungal pathogens biofilms drug resistance immunity stress response |
| title | Hidden allies: how extracellular vesicles drive biofilm formation, stress adaptation, and host–immune interactions in human fungal pathogens |
| title_full | Hidden allies: how extracellular vesicles drive biofilm formation, stress adaptation, and host–immune interactions in human fungal pathogens |
| title_fullStr | Hidden allies: how extracellular vesicles drive biofilm formation, stress adaptation, and host–immune interactions in human fungal pathogens |
| title_full_unstemmed | Hidden allies: how extracellular vesicles drive biofilm formation, stress adaptation, and host–immune interactions in human fungal pathogens |
| title_short | Hidden allies: how extracellular vesicles drive biofilm formation, stress adaptation, and host–immune interactions in human fungal pathogens |
| title_sort | hidden allies how extracellular vesicles drive biofilm formation stress adaptation and host immune interactions in human fungal pathogens |
| topic | extracellular vesicles fungal pathogens biofilms drug resistance immunity stress response |
| url | https://journals.asm.org/doi/10.1128/mbio.03045-23 |
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