Correlation of Hba1c, Triglyceride, HDL with the Degree of Stenosis in Coronary Heart Patients with Type 2 Diabetes Mellitus
Background: Coronary Heart Disease (CHD) is a disease caused by the narrowing of the coronary artery wall as a result of the atherosclerosis process. Atherosclerosis plays an important role from the beginning of plaque formation until plaque rupture which causes blood clots. Diabetes mellitus and dy...
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Bucharest College of Physicians
2024-06-01
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| Series: | Modern Medicine |
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| author | Neydi F SOUISA Budi SANTOSA Edward Kurnia Setiawan LIMIJADI |
| author_facet | Neydi F SOUISA Budi SANTOSA Edward Kurnia Setiawan LIMIJADI |
| author_sort | Neydi F SOUISA |
| collection | DOAJ |
| description | Background: Coronary Heart Disease (CHD) is a disease caused by the narrowing of the coronary artery wall as a result of the atherosclerosis process. Atherosclerosis plays an important role from the beginning of plaque formation until plaque rupture which causes blood clots. Diabetes mellitus and dyslipidemia are one of the major risk factors for CHD. In patients with type 2 Diabetes Mellitus, there was an altered lipid profile which led to endothelial damage that caused the formation of atherosclerosis. HDL cholesterol labeled as good cholesterol was decreased due to uncontrolled LDL cholesterol labeled as bad cholesterol. LDL cholesterol synthesis process was disrupted then causing plaque formation in the arteries which causes CHD. Aim: The aim of this study was to analysis correlation between HbA1c levels, triglyceride levels, HDL levels and the degree of stenosis in coronary heart disease sufferers with type 2 diabetes mellitus. Method: This study was an observational cross-sectional analytical study with total of 51 patients with CHD who underwent cardiac catheterization at Telogorejo Hospital. Semarang. The correlation test in this study using the Spearman test with p<0.05 is considered significant. Results: Results of this study show that there is no significant correlation between HbA1C levels and triglyceride levels (p= 0.793), and Hba1C with the degree of stenosis was (p= 0.685) but, there was significant correlation between HDL cholesterol level with the degree of stenosis (p=0.015). Conclusion: It was concluded that there was no significant correlation between the correlation of HbA1c levels and triglyceride levels with the degree of stenosis and there was a moderately negative significant correlation between HDL levels and the degree of stenosis. |
| format | Article |
| id | doaj-art-d12a644ee5e448259143b5daae8e750e |
| institution | Kabale University |
| issn | 1223-0472 2360-2473 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Bucharest College of Physicians |
| record_format | Article |
| series | Modern Medicine |
| spelling | doaj-art-d12a644ee5e448259143b5daae8e750e2025-08-20T03:24:59ZengBucharest College of PhysiciansModern Medicine1223-04722360-24732024-06-01312117122https://doi.org/10.31689/rmm.2024.31.2.117Correlation of Hba1c, Triglyceride, HDL with the Degree of Stenosis in Coronary Heart Patients with Type 2 Diabetes MellitusNeydi F SOUISA0Budi SANTOSA1https://orcid.org/0000-0003-0354-0136Edward Kurnia Setiawan LIMIJADI2https://orcid.org/0000-0002-8476-2971Faculty of Medicine, Diponegoro University, Semarang, IndonesiaFaculty of Medicine, Diponegoro University, Semarang, IndonesiaFaculty of Medicine, Diponegoro University, Semarang, IndonesiaBackground: Coronary Heart Disease (CHD) is a disease caused by the narrowing of the coronary artery wall as a result of the atherosclerosis process. Atherosclerosis plays an important role from the beginning of plaque formation until plaque rupture which causes blood clots. Diabetes mellitus and dyslipidemia are one of the major risk factors for CHD. In patients with type 2 Diabetes Mellitus, there was an altered lipid profile which led to endothelial damage that caused the formation of atherosclerosis. HDL cholesterol labeled as good cholesterol was decreased due to uncontrolled LDL cholesterol labeled as bad cholesterol. LDL cholesterol synthesis process was disrupted then causing plaque formation in the arteries which causes CHD. Aim: The aim of this study was to analysis correlation between HbA1c levels, triglyceride levels, HDL levels and the degree of stenosis in coronary heart disease sufferers with type 2 diabetes mellitus. Method: This study was an observational cross-sectional analytical study with total of 51 patients with CHD who underwent cardiac catheterization at Telogorejo Hospital. Semarang. The correlation test in this study using the Spearman test with p<0.05 is considered significant. Results: Results of this study show that there is no significant correlation between HbA1C levels and triglyceride levels (p= 0.793), and Hba1C with the degree of stenosis was (p= 0.685) but, there was significant correlation between HDL cholesterol level with the degree of stenosis (p=0.015). Conclusion: It was concluded that there was no significant correlation between the correlation of HbA1c levels and triglyceride levels with the degree of stenosis and there was a moderately negative significant correlation between HDL levels and the degree of stenosis.https://medicinamoderna.ro/wp-content/uploads/2024/06/Correlation-of-Hba1c-Triglyceride-HDL-with-the-Degree-of-Stenosis-in-Coronary-Heart-Patients-with-Type-2-Diabetes-Mellitus.pdfhba1chdltriglyceridecoronary heart diseasediabetes mellitus type 2 |
| spellingShingle | Neydi F SOUISA Budi SANTOSA Edward Kurnia Setiawan LIMIJADI Correlation of Hba1c, Triglyceride, HDL with the Degree of Stenosis in Coronary Heart Patients with Type 2 Diabetes Mellitus Modern Medicine hba1c hdl triglyceride coronary heart disease diabetes mellitus type 2 |
| title | Correlation of Hba1c, Triglyceride, HDL with the Degree of Stenosis in Coronary Heart Patients with Type 2 Diabetes Mellitus |
| title_full | Correlation of Hba1c, Triglyceride, HDL with the Degree of Stenosis in Coronary Heart Patients with Type 2 Diabetes Mellitus |
| title_fullStr | Correlation of Hba1c, Triglyceride, HDL with the Degree of Stenosis in Coronary Heart Patients with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Correlation of Hba1c, Triglyceride, HDL with the Degree of Stenosis in Coronary Heart Patients with Type 2 Diabetes Mellitus |
| title_short | Correlation of Hba1c, Triglyceride, HDL with the Degree of Stenosis in Coronary Heart Patients with Type 2 Diabetes Mellitus |
| title_sort | correlation of hba1c triglyceride hdl with the degree of stenosis in coronary heart patients with type 2 diabetes mellitus |
| topic | hba1c hdl triglyceride coronary heart disease diabetes mellitus type 2 |
| url | https://medicinamoderna.ro/wp-content/uploads/2024/06/Correlation-of-Hba1c-Triglyceride-HDL-with-the-Degree-of-Stenosis-in-Coronary-Heart-Patients-with-Type-2-Diabetes-Mellitus.pdf |
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