Non-detection of emerging and re-emerging pathogens in wastewater surveillance to confirm absence of transmission risk: A case study of polio in New York.
Infectious disease surveillance systems, including wastewater surveillance, can alert communities to the threat of emerging pathogens. We need methods to infer understanding of transmission dynamics from non-detection. We estimate a sensitivity of detection of poliovirus in wastewater to inform the...
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-01-01
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| Series: | PLOS Global Public Health |
| Online Access: | https://doi.org/10.1371/journal.pgph.0002381 |
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| _version_ | 1841555271531364352 |
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| author | David A Larsen Dustin Hill Yifan Zhu Mohammed Alazawi Dana Chatila Christopher Dunham Catherine Faruolo Brandon Ferro Alejandro Godinez Brianna Hanson Tabassum Insaf Dan Lang Dana Neigel Milagros Neyra Nicole Pulido Max Wilder Nan Yang Brittany Kmush Hyatt Green |
| author_facet | David A Larsen Dustin Hill Yifan Zhu Mohammed Alazawi Dana Chatila Christopher Dunham Catherine Faruolo Brandon Ferro Alejandro Godinez Brianna Hanson Tabassum Insaf Dan Lang Dana Neigel Milagros Neyra Nicole Pulido Max Wilder Nan Yang Brittany Kmush Hyatt Green |
| author_sort | David A Larsen |
| collection | DOAJ |
| description | Infectious disease surveillance systems, including wastewater surveillance, can alert communities to the threat of emerging pathogens. We need methods to infer understanding of transmission dynamics from non-detection. We estimate a sensitivity of detection of poliovirus in wastewater to inform the sensitivity of wastewater surveillance for poliovirus using both a clinical epidemiology and fecal shedding approach. We then apply freedom from disease to estimate the sensitivity of the wastewater surveillance network. Estimated sensitivity to detect a single poliovirus infection was low, <11% at most wastewater treatment plants and <3% in most counties. However, the maximum threshold for the number of infections when polio is not detected in wastewater was much lower. Prospective wastewater surveillance can confirm the absence of a polio threat and be escalated in the case of poliovirus detection. These methods can be applied to any emerging or re-emerging pathogen, and improve understanding from wastewater surveillance. |
| format | Article |
| id | doaj-art-d1293fa015a346a4aaeb801742f9c187 |
| institution | Kabale University |
| issn | 2767-3375 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLOS Global Public Health |
| spelling | doaj-art-d1293fa015a346a4aaeb801742f9c1872025-01-08T05:51:31ZengPublic Library of Science (PLoS)PLOS Global Public Health2767-33752024-01-01412e000238110.1371/journal.pgph.0002381Non-detection of emerging and re-emerging pathogens in wastewater surveillance to confirm absence of transmission risk: A case study of polio in New York.David A LarsenDustin HillYifan ZhuMohammed AlazawiDana ChatilaChristopher DunhamCatherine FaruoloBrandon FerroAlejandro GodinezBrianna HansonTabassum InsafDan LangDana NeigelMilagros NeyraNicole PulidoMax WilderNan YangBrittany KmushHyatt GreenInfectious disease surveillance systems, including wastewater surveillance, can alert communities to the threat of emerging pathogens. We need methods to infer understanding of transmission dynamics from non-detection. We estimate a sensitivity of detection of poliovirus in wastewater to inform the sensitivity of wastewater surveillance for poliovirus using both a clinical epidemiology and fecal shedding approach. We then apply freedom from disease to estimate the sensitivity of the wastewater surveillance network. Estimated sensitivity to detect a single poliovirus infection was low, <11% at most wastewater treatment plants and <3% in most counties. However, the maximum threshold for the number of infections when polio is not detected in wastewater was much lower. Prospective wastewater surveillance can confirm the absence of a polio threat and be escalated in the case of poliovirus detection. These methods can be applied to any emerging or re-emerging pathogen, and improve understanding from wastewater surveillance.https://doi.org/10.1371/journal.pgph.0002381 |
| spellingShingle | David A Larsen Dustin Hill Yifan Zhu Mohammed Alazawi Dana Chatila Christopher Dunham Catherine Faruolo Brandon Ferro Alejandro Godinez Brianna Hanson Tabassum Insaf Dan Lang Dana Neigel Milagros Neyra Nicole Pulido Max Wilder Nan Yang Brittany Kmush Hyatt Green Non-detection of emerging and re-emerging pathogens in wastewater surveillance to confirm absence of transmission risk: A case study of polio in New York. PLOS Global Public Health |
| title | Non-detection of emerging and re-emerging pathogens in wastewater surveillance to confirm absence of transmission risk: A case study of polio in New York. |
| title_full | Non-detection of emerging and re-emerging pathogens in wastewater surveillance to confirm absence of transmission risk: A case study of polio in New York. |
| title_fullStr | Non-detection of emerging and re-emerging pathogens in wastewater surveillance to confirm absence of transmission risk: A case study of polio in New York. |
| title_full_unstemmed | Non-detection of emerging and re-emerging pathogens in wastewater surveillance to confirm absence of transmission risk: A case study of polio in New York. |
| title_short | Non-detection of emerging and re-emerging pathogens in wastewater surveillance to confirm absence of transmission risk: A case study of polio in New York. |
| title_sort | non detection of emerging and re emerging pathogens in wastewater surveillance to confirm absence of transmission risk a case study of polio in new york |
| url | https://doi.org/10.1371/journal.pgph.0002381 |
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