A Case of GATA3 Positive Pleomorphic Liposarcoma, Epithelioid Variant: A Diagnostic Pitfall
Pleomorphic liposarcoma is a rare malignant adipocytic tumor showing undifferentiated pleomorphic sarcoma morphology with various degrees of epithelioid features. It is sometimes difficult to distinguish from carcinoma metastasis. Immunohistochemical panel is very important for differential diagnosi...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2023/9443027 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832547876743413760 |
|---|---|
| author | Makoto Abe Nobuo Hoshi Sayuri Hoshi Kaoru Hirabayashi Kazutaka Kikuta Toru Hirozane Rumi Nakagawa Tsukasa Mizuno Hiroshi Nakamura Koichi Inoue Takehiko Yamaguchi |
| author_facet | Makoto Abe Nobuo Hoshi Sayuri Hoshi Kaoru Hirabayashi Kazutaka Kikuta Toru Hirozane Rumi Nakagawa Tsukasa Mizuno Hiroshi Nakamura Koichi Inoue Takehiko Yamaguchi |
| author_sort | Makoto Abe |
| collection | DOAJ |
| description | Pleomorphic liposarcoma is a rare malignant adipocytic tumor showing undifferentiated pleomorphic sarcoma morphology with various degrees of epithelioid features. It is sometimes difficult to distinguish from carcinoma metastasis. Immunohistochemical panel is very important for differential diagnosis; however, there is a risk that unexpected staining could lead to misinterpretation. We report a pleomorphic liposarcoma, epithelioid variant, in an 88-year-old man, with tricky-positive staining for GATA3. Histological examination revealed a tumor with epithelioid morphology. The tumor consists of solid sheets of epithelioid tumor cells with focal aggregates of pleomorphic lipoblasts. Immunohistochemically, the adipocytic tumor cell areas were positive for S100 protein, and the epithelioid tumor cells showed CAM 5.2 positivity. GATA3 was diffusely positive. The combination of CAM 5.2 and GATA3 staining suggested the possibility of metastatic cancer, but systemic clinical examinations did not detect any presence of a primary tumor, including urinary bladder, breasts, and salivary glands. The pathological diagnosis of pleomorphic liposarcoma, epithelioid variant, was made because of the presence of malignant lipoblasts. Our report may contribute for differential diagnosis of pleomorphic liposarcoma, epithelioid variant, with unexpected positive immunoreaction for GATA3. |
| format | Article |
| id | doaj-art-d128c6a833c447e98aee578f209edafb |
| institution | Kabale University |
| issn | 2090-679X |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-d128c6a833c447e98aee578f209edafb2025-02-03T06:43:13ZengWileyCase Reports in Pathology2090-679X2023-01-01202310.1155/2023/9443027A Case of GATA3 Positive Pleomorphic Liposarcoma, Epithelioid Variant: A Diagnostic PitfallMakoto Abe0Nobuo Hoshi1Sayuri Hoshi2Kaoru Hirabayashi3Kazutaka Kikuta4Toru Hirozane5Rumi Nakagawa6Tsukasa Mizuno7Hiroshi Nakamura8Koichi Inoue9Takehiko Yamaguchi10Department of PathologyDepartment of PathologyDepartment of PathologyDepartment of PathologyDepartment of Musculoskeletal Oncology and Orthopaedic SurgeryDepartment of Musculoskeletal Oncology and Orthopaedic SurgeryDepartment of Musculoskeletal Oncology and Orthopaedic SurgeryDepartment of Musculoskeletal Oncology and Orthopaedic SurgeryDepartment of Musculoskeletal Oncology and Orthopaedic SurgeryDepartment of Radiation Oncology and Image-Applied TherapyDepartment of PathologyPleomorphic liposarcoma is a rare malignant adipocytic tumor showing undifferentiated pleomorphic sarcoma morphology with various degrees of epithelioid features. It is sometimes difficult to distinguish from carcinoma metastasis. Immunohistochemical panel is very important for differential diagnosis; however, there is a risk that unexpected staining could lead to misinterpretation. We report a pleomorphic liposarcoma, epithelioid variant, in an 88-year-old man, with tricky-positive staining for GATA3. Histological examination revealed a tumor with epithelioid morphology. The tumor consists of solid sheets of epithelioid tumor cells with focal aggregates of pleomorphic lipoblasts. Immunohistochemically, the adipocytic tumor cell areas were positive for S100 protein, and the epithelioid tumor cells showed CAM 5.2 positivity. GATA3 was diffusely positive. The combination of CAM 5.2 and GATA3 staining suggested the possibility of metastatic cancer, but systemic clinical examinations did not detect any presence of a primary tumor, including urinary bladder, breasts, and salivary glands. The pathological diagnosis of pleomorphic liposarcoma, epithelioid variant, was made because of the presence of malignant lipoblasts. Our report may contribute for differential diagnosis of pleomorphic liposarcoma, epithelioid variant, with unexpected positive immunoreaction for GATA3.http://dx.doi.org/10.1155/2023/9443027 |
| spellingShingle | Makoto Abe Nobuo Hoshi Sayuri Hoshi Kaoru Hirabayashi Kazutaka Kikuta Toru Hirozane Rumi Nakagawa Tsukasa Mizuno Hiroshi Nakamura Koichi Inoue Takehiko Yamaguchi A Case of GATA3 Positive Pleomorphic Liposarcoma, Epithelioid Variant: A Diagnostic Pitfall Case Reports in Pathology |
| title | A Case of GATA3 Positive Pleomorphic Liposarcoma, Epithelioid Variant: A Diagnostic Pitfall |
| title_full | A Case of GATA3 Positive Pleomorphic Liposarcoma, Epithelioid Variant: A Diagnostic Pitfall |
| title_fullStr | A Case of GATA3 Positive Pleomorphic Liposarcoma, Epithelioid Variant: A Diagnostic Pitfall |
| title_full_unstemmed | A Case of GATA3 Positive Pleomorphic Liposarcoma, Epithelioid Variant: A Diagnostic Pitfall |
| title_short | A Case of GATA3 Positive Pleomorphic Liposarcoma, Epithelioid Variant: A Diagnostic Pitfall |
| title_sort | case of gata3 positive pleomorphic liposarcoma epithelioid variant a diagnostic pitfall |
| url | http://dx.doi.org/10.1155/2023/9443027 |
| work_keys_str_mv | AT makotoabe acaseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT nobuohoshi acaseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT sayurihoshi acaseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT kaoruhirabayashi acaseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT kazutakakikuta acaseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT toruhirozane acaseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT ruminakagawa acaseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT tsukasamizuno acaseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT hiroshinakamura acaseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT koichiinoue acaseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT takehikoyamaguchi acaseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT makotoabe caseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT nobuohoshi caseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT sayurihoshi caseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT kaoruhirabayashi caseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT kazutakakikuta caseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT toruhirozane caseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT ruminakagawa caseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT tsukasamizuno caseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT hiroshinakamura caseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT koichiinoue caseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall AT takehikoyamaguchi caseofgata3positivepleomorphicliposarcomaepithelioidvariantadiagnosticpitfall |