Rituximab Induced Pulmonary Edema Managed with Extracorporeal Life Support
Though rare, rituximab has been reported to induce severe pulmonary edema. We describe the first report of ECLS utilization for this indication. A 31-year-old female with severe thrombotic thrombocytopenic purpura developed florid pulmonary edema after rituximab infusion. Despite advanced ventilator...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2018/6039045 |
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| _version_ | 1832549888959709184 |
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| author | Jacob R. Miller Warren Isakow Muhammad F. Masood Patrick Aguilar Kristen M. Sanfilippo Keki R. Balsara Akinobu Itoh |
| author_facet | Jacob R. Miller Warren Isakow Muhammad F. Masood Patrick Aguilar Kristen M. Sanfilippo Keki R. Balsara Akinobu Itoh |
| author_sort | Jacob R. Miller |
| collection | DOAJ |
| description | Though rare, rituximab has been reported to induce severe pulmonary edema. We describe the first report of ECLS utilization for this indication. A 31-year-old female with severe thrombotic thrombocytopenic purpura developed florid pulmonary edema after rituximab infusion. Despite advanced ventilatory settings, she developed severe respiratory acidosis and remained hypoxemic with a significant vasopressor requirement. Since her pulmonary insult was likely transient, ECLS was considered. Due to combined cardiorespiratory failure, she received support with peripheral venoarterial ECLS. During her ECLS course, she received daily plasmapheresis and high dose steroids. Her pulmonary function recovered and she was decannulated after 8 days. She was discharged after 23 days without residual sequelae. |
| format | Article |
| id | doaj-art-d12718b1f63e4e62b7bbccb3697b98b1 |
| institution | Kabale University |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-d12718b1f63e4e62b7bbccb3697b98b12025-02-03T06:08:21ZengWileyCase Reports in Critical Care2090-64202090-64392018-01-01201810.1155/2018/60390456039045Rituximab Induced Pulmonary Edema Managed with Extracorporeal Life SupportJacob R. Miller0Warren Isakow1Muhammad F. Masood2Patrick Aguilar3Kristen M. Sanfilippo4Keki R. Balsara5Akinobu Itoh6Division of Cardiothoracic Surgery, Washington University, St. Louis, MO, USADivision of Pulmonary Critical Care, Washington University, St. Louis, MO, USADivision of Cardiothoracic Surgery, Washington University, St. Louis, MO, USADivision of Pulmonary Critical Care, Washington University, St. Louis, MO, USADivision of Hematology, Washington University, St. Louis, MO, USADivision of Cardiothoracic Surgery, Washington University, St. Louis, MO, USADivision of Cardiothoracic Surgery, Washington University, St. Louis, MO, USAThough rare, rituximab has been reported to induce severe pulmonary edema. We describe the first report of ECLS utilization for this indication. A 31-year-old female with severe thrombotic thrombocytopenic purpura developed florid pulmonary edema after rituximab infusion. Despite advanced ventilatory settings, she developed severe respiratory acidosis and remained hypoxemic with a significant vasopressor requirement. Since her pulmonary insult was likely transient, ECLS was considered. Due to combined cardiorespiratory failure, she received support with peripheral venoarterial ECLS. During her ECLS course, she received daily plasmapheresis and high dose steroids. Her pulmonary function recovered and she was decannulated after 8 days. She was discharged after 23 days without residual sequelae.http://dx.doi.org/10.1155/2018/6039045 |
| spellingShingle | Jacob R. Miller Warren Isakow Muhammad F. Masood Patrick Aguilar Kristen M. Sanfilippo Keki R. Balsara Akinobu Itoh Rituximab Induced Pulmonary Edema Managed with Extracorporeal Life Support Case Reports in Critical Care |
| title | Rituximab Induced Pulmonary Edema Managed with Extracorporeal Life Support |
| title_full | Rituximab Induced Pulmonary Edema Managed with Extracorporeal Life Support |
| title_fullStr | Rituximab Induced Pulmonary Edema Managed with Extracorporeal Life Support |
| title_full_unstemmed | Rituximab Induced Pulmonary Edema Managed with Extracorporeal Life Support |
| title_short | Rituximab Induced Pulmonary Edema Managed with Extracorporeal Life Support |
| title_sort | rituximab induced pulmonary edema managed with extracorporeal life support |
| url | http://dx.doi.org/10.1155/2018/6039045 |
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